Algemene en differensiële breinafwykings in dobbelstoornis subtipes gebaseer op risiko houding (2017)

Verslaafde Behav. 2017 Jun;69:48-54. doi: 10.1016/j.addbeh.2017.01.025.

Takeuchi H1, Tsurumi K1, Murao T1, Takemura A1, Kawada R1, Urayama SI2, Aso T2, Sugihara GI1, Miyata J1, Murai T1, Takahashi H3.

Abstract

Studying brain abnormalities in behavioral addiction including GD enables us to exclude possible confounding effects of exposure to neurotoxic substances, which should provide important insight that can lead to a better understanding of addiction per se. There have been a few brain structural magnetic resonance imaging studies for GD, although the results have been inconsistent. On the other hand, GD was suggested to be a heterogeneous disorder in terms of risk attitude. We aimed to examine the heterogeneity of GD by combining a behavioral economics task and voxel-based morphometry. Thirty-six male GD patients and 36 healthy male control subjects underwent a task for estimation of loss aversion, which can assess risk attitude in real-life decision-making. The GD patients were divided into two groups based on their level of loss aversion, low and high. While both groups showed common gray matter volume reduction in the left supramarginal gyrus and bilateral posterior cerebellum, high loss-aversion GD showed pronounced reduction in the left posterior cerebellum and additional reduction in the bilateral medial orbitofrontal cortex. Our study suggests that the heterogeneity of GD is underpinned at the brain structural level. This result might be useful for understanding neurobiological mechanisms and for the establishment of precise treatment strategies for GD.

SLEUTELWOORDE: Gambling disorder; Gray matter volume; Loss aversion; Subtypes

PMID: 28131932

DOI: 10.1016 / j.addbeh.2017.01.025