Bron
Department of Psychiatry, Chung Ang University, College of Medicine.
Abstract
Bupropion is gebruik in die behandeling van pasiënte met substansafhanklikheid gebaseer op die swak inhibisie van dopamien- en norepinefrienheropname.
Ons het veronderstel dat 6 weke se behandeling met volgehoue vrystelling van bupropion (SR) die lus vir internetspeletjies sowel as breinaktiwiteit wat deur videospeletjies veroorsaak word, sal verminder by pasiënte met internetvideospeletjieverslawing (IAG).
Eleven subjects who met criteria for IAG, playing StarCraft (>30 hr/week), and eight healthy comparison subjects (HC) who had experience playing StarCraft (<3 days/week and <1 hr/day). At baseline and at the end of 6 weeks of bupropion SR treatment, brain activity in response to StarCraft cue presentation was assessed using 1.5 Tesla functional MRI. In addition, symptoms of depression, craving for playing the game, and the severity of Internet addiction were evaluated by Beck Depression Inventory, self-report of craving on a 7-point visual analogue scale, and Young’s Internet Addiction Scale, respectively.
In response to game cues, IAG showed higher brain activation in left occipital lobe cuneus, left dorsolateral prefrontal cortex, and left parahippocampal gyrus than HC.
Na 'n tydperk van 6 weke van bupropion SR, drang na internetvideospeletjies, totale speltyd en cue-geïnduseerde breinaktiwiteit in dorsolaterale prefrontale korteks is in die IAG verminder. Ons stel voor dat bupropion SR drang en breinaktiwiteit kan verander op maniere wat soortgelyk is aan dié wat waargeneem word by individue met dwelmmisbruik of -afhanklikheid.
;