Ka Noho Alii Kiekie. 2014 Jul 16. ^ E Ha yM. pii: S0022-3956 (14) 00204-0. doi: 10.1016 / j.jpsychires.2014.07.007.
Han DH1, Lee YS1, Shi X2, Renshaw PF3.
Hōʻuluʻulu Manaʻo
Ua noi ʻia nā noiʻi imaging hou ʻehā a ʻo nā cortice mua a me ka hoʻoliʻu kino i nā wahi pōkole pili i ka hoʻomohala ʻana i nā ʻike o ka pili ʻana o ka pūnaewele. Hōʻike mākou i nā hemahema o ka hana cortical prefrontal a temporal i loko o nā mea maʻi me ka hoʻokūkū pāʻani on-line (PGA) e hōʻike ʻia i nā haʻahaʻa o nā pae N-acetyl aspartate (NAA) a me ka cytosolic, ka choline i loaʻa ka pūpū (Cho). He ʻumikūmākolu mau keiki PGA a me 38 mau makahiki a me nā kāne i hoʻokele i ke ola olakino i mālama ʻia i loko o ke aʻo ʻana. Hoʻolālā MR a 1Ua loaʻa ka ʻikepili ʻo H MRS ma ka hoʻohana ʻana i kahi scanner 3.0 T MRI. Hoʻonoho hoʻonohonoho ʻia nā Voxels i ka mua o ka mua a me nā kihi waena waena waena. I ka mua o ka ʻaoʻao mua, ua ʻoi aku ka haʻahaʻa o nā pae o ka NAA ma PGA ma mua o nā mana olakino. I loko o ka medial cortex kino, ua emi nā pae o Cho i nā mea komo PGA ma mua o nā mea i ʻike ʻia i nā kaohi olakino. Ua hoʻopili maikaʻi ʻole ʻia nā helu o ka ʻōnaehana ʻōpio ʻōpio (YIAS) a me nā pane hoʻomanawanui ma PGA me ka pae o NAA ma ka ʻaoʻao mua. Ua hoʻopili maikaʻi ʻole ʻia nā helu o ka Beck Depressive Inventory (BDI) i ka pūʻulu PGA me nā pae Cho ma ka ʻupena kino kūpono. I ka ʻike maikaʻi loa o kā mākou ʻike, ʻo ia ka haʻawina mua o ka MRS o kēlā me kēia kanaka me ka pāʻani add on line. ʻOiai, ʻo nā kumumanaʻo me ka pili o ka pāʻani ma ke aʻo i ka aʻo i kēia manawa, he manuahi mai ka psychiatric co-morbidity, nā mea maʻi me ka papa hoʻokūkū ma ka huina e hele mai e hōʻike i nā hiʻohiʻona me ADHD a me MDD e pili ana i nā loli neurochemical ma mua o nā cortices mua.
KEYWORDS:
ʻO Choline kahi pūhui lulu; ʻOrtlelo cortex; He cortex pili kino; N-acetyl aspartate
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