Neuropharmacology. 2014 Feb; 77: 224-33. doi: 10.1016 / j.neuropharm.2013.09.019.
Lazenka MF1, Selley DE1, Sim-Selley LJ2.
Abstract
Rov ua dua Δ (9) -tetrahydrocannabinol (THC) kev tswj tsim tawm kev txo thiab kev txo qis rau hom kab xNUMX receptors (CB®Rs) hauv lub hlwb, tiam sis qhov loj ntawm cov kev hloov kho no txawv ntawm cheeb tsam. CB₁Rs nyob rau hauv striatum thiab nws cov cheeb tsam zais tau tawm qhov tsawg tshaj plaws qhov siab thiab kev loj hlob qeeb ntawm desensitization thiab downregulation. Cov mechanisms molecular uas muab cov kev sib txawv hauv cheeb tsam no tsis paub. Qhov tseem ceeb tshaj plaws ntawm kev hloov qis, ΔFosB, yog qhov tshwm sim nyob rau hauv cov kab mob hauv qab no ua raws li THC kev tswj hwm thiab tswj tau CB®Rs. Kom ncaj qha mus piv rau lub cheeb tsam profile ntawm ΔFosB induction thiab CB₁R desensitization thiab downregulation, cov nas tau kho nrog THC (1 mg / kg) los yog lub tsheb rau 10 hnub. CP13.5-stimulated [(55,940) S] GTPVS autoradiography thiab immunohistochemistry tau ntsuas los ntsuas CB®R desensitization thiab downregulation, feem, thiab qhia ΔFosB yog ntsuas los ntawm kev txhaj tshuaj tiv thaiv kab mob. CBER desensitization thiab txo qhov teeb meem tshwm sim nyob rau hauv prefrontal cortex, lateral amygdala thiab hippocampus; Desensitization twb pom nyob hauv basomedial amygdala thiab tsis muaj kev hloov tau pom hauv thaj tsam seem. ΔFosB raug ntxias nyob hauv prefrontal cortex, caudate-putamen, nucleus accumbens thiab lateral amygdala. Ib qho kev sib raug zoo hauv cheeb tsam ntawm cov kev qhia ΔFosB thiab CB₁R desensitization tau pom, xws li cov cheeb tsam uas muaj qhov loj tshaj ΔFosB qhov tsis tuaj yeem tsis pom CB®R desensitization thiab thaj chaw uas tsis muaj ΔFosB qhov kev xav tau qhov kev tshaj tawm zoo tshaj plaws, nrog rau cov cheeb tsam uas pom cov theem nrab ntawm ob qho tib si. Dual immunohistochemistry hauv qhov kev ntsuas tau pom ob qho tib si CB₁R co-localization nrog ΔFosB hauv hlwb thiab CB₁R puncta ib puag ncig ΔFosB-zoo hlwb. THC-induced qhia ntawm ΔFosB tsis tuaj hauv striatum ntawm CB₁R knockout nas. Cov ntaub ntawv no qhia tau tias cov hom phiaj ntawm ΔFosB yuav thaiv tau CB®R desensitization thiab / los yog qhov kev tshem tawm ΔFosB yuav raug txwv los ntawm CB₁R desensitization.
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