Molecular imaging qhia tau hais tias mob cawv haus luam yeeb cuam tshuam rau lub hlwb lub hlwb
Lub Xya hli ntuj 6th, 2011 hauv Neuroscience
Cov ntsiab lus tseem ceeb ntawm cov kev mob tshwm sim tsis zoo ntawm kev siv tshuaj maj ua kom tshwm sim ntawm SNM's 58th Lub Rooj Sib Tham Txhua Xyoo tuaj yeem ua rau muaj peev xwm kho tau cov tshuaj thiab pab lwm cov kev tshawb fawb koom nrog cannabinoid receptors, lub zog neurotransmission uas tau txais kev mloog ntau. Cov kws tshawb fawb tau siv molecular imaging kom pom kev hloov pauv ntawm lub hlwb ntawm cov neeg haus luam yeeb hnyav piv rau cov tsis haus luam yeeb thiab pom tias kev siv yeeb tshuaj ua rau muaj kev txo qis ntawm cannabinoid CB1 receptors, uas koom nrog tsis yog kev lom zem, qab los noj mov thiab mob siab rau tab sis tus tswv tsev ntawm lwm yam kev xav ntawm lub hlwb thiab lub dag lub zog ntawm lub cev.
Jussi Hirvonen, MD, PhD, tus thawj coj ntawm kev sib koom tes tshawb fawb los ntawm National Institute of Mental Health thiab National Institute txog Kev Tsim Txom, "Bethesda, Md" hais tias "Hmoov tsis zoo, peb tsis tau ua txhua yam nkag siab txog cov neurobiological mechanisms kev cuam tshuam nrog rau kev quav. Nrog rau qhov kev kawm no, peb tau tuaj yeem qhia thawj zaug tias cov tib neeg uas tsim txom cannabis muaj kev txawv txav ntawm cannabinoid receptors hauv lub hlwb. Cov ntaub ntawv no tuaj yeem ua pov thawj rau kev tsim kho tshiab ntawm kev kho mob cannabis. Tsis tas li ntawd, cov kev tshawb fawb no qhia tau hais tias cov neeg tau txais qis qis dua nyob hauv cov neeg uas ua phem rau cannabis rov qab zoo li qub thaum lawv txiav luam yeeb. "
Raws li National Institute on Drug Abuse, marijuana yog tus naj npawb-ib qho tshuaj txhaum cai ntawm kev xaiv hauv Tebchaws Asmeskas. Cov tshuaj hu ua psychoactive hauv marijuana, los yog cannabis, yog delta-9-tetrahydrocannabinol (THC), uas khi rau ntau tus kab mob cannabinoid receptors nyob rau hauv lub hlwb thiab thoob plaws lub cev thaum haus los yog noj mis, ua qhov txawv txav. Cannabinoid receptors nyob rau hauv lub hlwb lub zog ntawm ntau lub hlwb thiab cov kev ua, xws li Library, concentration, xaav lub sij hawm thiab nco, hnov kev xav, thiab kev sib koom tes ntawm kev khiav. Tseem muaj cov kab mob cannabinoid thoob plaws hauv lub cev uas koom rau hauv ntau lub zog ntawm tus digestive, plawv, pa thiab lwm yam hauv lub cev. Tam sim no ob subtypes ntawm cannabinoid receptors paub, CB1 thiab CB2, tus qub tau koom tes feem ntau nyob rau hauv functions ntawm lub hauv paus paj hlwb thiab lub tom kawg ntau nyob rau hauv functions ntawm lub cev thiab nyob rau hauv qia hlwb ntawm lub circulatory system.
Rau txoj kev tshawb no, cov kws tshawb nrhiav tau tshawb nrhiav 30 niaj hnub cannabis cov neeg haus luam yeeb uas tau saib xyuas tom tsev kho mob kaw li ntawm plaub lub lim tiam. Cov ntsiab lus raug coj los siv cov positron emission tomography (PET), uas muab cov ntaub ntawv hais txog kev siv lub cev hauv lub cev. Cov kev kawm raug txhaj tshuaj nrog lub radioligand, 18F-FMPEP-d2, uas yog kev sib txuas ntawm cov tshuaj fluorine fluorine thiab ib tus neurotransmitter analog uas khi nrog CB1 lub hlwb tawm suab.
Cov qhab-nees ntawm qhov kev tshawb nrhiav pom tias tus neeg tau txais kev pabcuam tau tsawg dua txog 20 feem pua ntawm cov neeg uas muaj kabmob kasmoos haus thaum piv rau cov kev tswj kev noj qab haus huv uas tsuas pub kis tau rau hom kab mob hauv lub neej. Cov kev hloov no tau pom tias muaj kev sib raug zoo nrog cov xyoo kawm tau haus luam yeeb. Ntawm tus thawj 30 cannabis cov neeg haus luam yeeb, 14 ntawm cov kev ua hauv qab tus thib ob cov kua TSUAS tom qab txog ib lub hlis ntawm kev tshem tawm. Muaj ib qho kev nce rau hauv kev ua haujlwm hauv cov chaw uas tau poob rau ntawm qhov pib ntawm txoj kev tshawb no, qhov qhia tias thaum cov kab mob cannabis kev haus luam yeeb ua rau kev txo qis ntawm CB1 receptors, qhov kev puas tsuaj yog rov qab hloov dua siab tshiab.
Cov ntaub ntawv uas tau txais los ntawm txoj kev kawm no thiab yav tom ntej yuav pab tau lwm cov kev tshawb fawb tshawb txog lub luag haujlwm ntawm PET kuaj ntawm CB1 receptors-tsis yog siv yeeb tshuaj, tab sis kuj rau ntau yam kab mob ntawm tib neeg, nrog rau cov kab mob metabolic thiab cancer.
Xav paub ntau ntxiv: Daim Ntawv Qhia Txog Kev Tshawb Fawb 10: J. Hirvonen, R. Goodwin, C. Li1, G. Terry, S. Zoghbi, C Morse, V. Pike, N. Volkow, M. Huestis, R. Innis, Lub Koom Haum Hauv Tebchaws ntawm Mental Kev Noj Qab Haus Huv, Bethesda, MD; Koom haum National ntawm Kev Siv Yuam Yeeb, Baltimore, MD; "Kev thim rov qab thiab ib cheeb tsam kev xaiv qis qis ntawm lub hlwb cannabinoid CB1 receptors nyob rau hauv cov neeg haus luam yeeb txhua hnub," SNM lub Rooj Sib Tham Xyoo 58, Lub Rau Hli 4-8, 2011, San Antonio, TX.
Muab los ntawm Society ntawm Nuclear Tshuaj
Molecular imaging qhia tau hais tias mob cawv haus luam yeeb cuam tshuam rau lub hlwb lub hlwb.
;
