IHE: Mmegbu mmekọahụ bụ oke akara site na mgbanwe ụbụrụ ọtụtụ na-ewe ma ọ dịkarịa ala ụbọchị 4 iji gbanwee. N'otu oge ahụ, mgbake zuru oke nke inwe mmekọahụ (ọnụ ọgụgụ nke ndị na-eme ka ndị na-eme ihe na-akpata) na-ewe ụbọchị 15. Onye nyocha a kwenyere, dị ka anyị na-eme, na agụụ mmekọahụ bụ usoro iji gbochie mkpali nke ụgwọ ọrụ ụgwọ ọrụ.
Site n'ọmụmụ: Enwere ike iche na mgbochi ogologo oge mmekọahụ na-esite na ntinye obi na satiation bụ usoro nchebe pụọ na mkpali nke ụbụrụ ụbụrụ nke na-etinye aka na nhazi ya. Usoro mesolimbic na-ekere òkè na nhazi nke ụgwọ ọrụ ndị sitere n'okike gụnyere omume mmekọahụ [2]. Imukpali akpali nke sekit a site na nchịkwa ọgwụ ugboro ugboro nke ị abuseụ ọgwụ na-eme ka akparamagwa [16] nke yiri oke ọgwụ na-egosipụta oke oke na-egosipụta mmekọahụ mgbe mmesịrị ugboro ugboro na obere oge, nke ga na-akpali usoro mesolimbic ugboro ugboro.
Behav Brain Res. 2011 Mar 1; 217 (2): 253-60. doi: 10.1016 / j.bbr.2010.09.014. Epub 2010 Sep 25.
Rodríguez-Manzo G1, Guadarrama-Bazante IL, Morales-Calderón A.
Source
Departamento de Farmacobiología, Cinvestav, IPN-Sede Sur, Calzada de los Tenorios 235, Delegación Tlalpan, México 14330 DF, Mexico. [email protected]
nkịtị
Oke oke kwere ka nwoke na nwanyị na - eme nri nke ọma na - egbu mmụọ ugboro ugboro ruo mgbe iwere ha. Abalị iri abụọ na anọ ka usoro a gasịrị, ụmụ nwoke ike gwụrụ na-egosiputa mgbanwe dị iche iche na-arịa ọrịa ma e jiri ha tụnyere ụmụ nwoke anaghị agwụ ike. N'etiti ha, ndị akachasịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịsịke siriri zọbụ bụ mmachi omume mmekọahụ na-adịte aka na nchịkọta zuru oke maka omume ọgwụ. Ebumnuche nke ọrụ dị ugbu a bụ iji guzobe ma ọ nwere nkwekọrịta dị n'etiti atụmatụ abụọ ndị a nke satiation mmekọahụ metụtara oge ngosipụta ya. Ebumnuche ahụ, anyị mere ka usoro omume nwute mmekọahụ site na agụụ mmekọahụ, yana oge nke ịgwọ ọrịa ọgwụ riri ahụ. A na-enyocha nke ikpeazụ site n'ọdịdị nke ihe ịrịba ama nke ọrịa serotonergic: ọnọdụ dị larịị. Nsonaazụ gosipụtara na ọgwụ ọjọọ ahụrụ mmụọ na ihe mgbochi mmekọahụ nke na-esite na copulation rue satiation na-esochi oge mgbake, na mgbada dị ukwuu na nkwupụta ha 96 h mgbe usoro satiation mmekọahụ. Nchọpụta a na-egosi na ihe omume ndị a nwere ike ịnọchite anya ngosipụta abụọ nke otu sistemu plastik, dịka agwa ogologo oge ga-adị na-egosi, nke ga-atọ gị ụtọ ịgbanwe.
Copyright © 2010 Elsevier BV Ikike niile echekwabara.
Erimeri akwukwo nke zuru oke:
A na-akọwa satiation mmekọahụ ka ọ bụrụ ogologo oge inhibitory mmekọahụ nke na-apụta mgbe ejikọtara ọnụ ugboro ugboro na oge mgbasa ozi na-aga n'ihu [2,12]. Abalị iri abụọ na anọ mgbe usoro ịgwụ ike gwụchara, oke oke na-akpa agwa n'ụzọ abụọ dị iche iche n'ihu nwanyị na-anabata ya: ụzọ n'ụzọ atọ n'ime ha egosighi ihe ọ bụla agụụ mmekọahụ na nke atọ fọdụrụnụ nwere ike iwepụ ya otu ugboro, na-enweghị ịmaliteghachi mmekọahụ mgbe nke ahụ gasịrị. ejaculation [18]. Yabụ, mmadụ abụọ nwere oke rash na ike mmekọahụ nwere ike iche 24 h mgbe akpachapụrụ anya na satiation, nzaghachi na nke na-anaghị aza ya. N’otu oge nnwale a (24 h), oke oke nwoke nwere mmekọahụ na-egosipụta oke mgbanwe anụ ahụ ma e jiri ya tụnyere ụmụ nwoke na-adịghị agwụ ike.
Dịka ọmụmaatụ, mkpali eletrik nke mpaghara ụbụrụ tinyere aka na njikwa nke omume copulatory dị ka mpaghara preoptic akụkụ [23], mpaghara ventral tegmental [20] na ngụkọta akwara [21] na-eme ka ngosipụta omume mmekọahụ na oke oke nwoke nwere mmekọahụ, mana enweghị nke mmetụta n'otu isiokwu ahụ mgbe ike gwụrụ mmekọahụ.
Mgbanwe ọzọ na-ezo aka na mmetụta anxiolytic yiri nke ejaculation nke akọwara na oke oke nwoke nwere mmekọahụ [9]. Ngwongwo ejuputa a pụtara mgbe otu, agam abuo ma obu isii, agam agbasa, 24 h mgbe ngwu satiation, bu nbido iwepu nmekorita nwoke na nwanyi, ejuputa gosiputara site na nnabata ndi anumanu enwegh ike na adighi agwu [22 ].
N'ikpeazụ, nchọpụta na-agbanwe agbanwe mgbe ị na-eji oke agwọ ọrịa nwere oke oke nwere mmekọahụ bụ ngosipụta nke ịgwọ ọrịa ọgwụ.
Ya mere, na oke onwu riri nne nke nwanyi serotonergic 5-HT1A receptor agonist, 8-hydroxy-di-propil amino tetraline (8-OH-DPAT), na mgbakwunye na iweghachite akparamagwa nwoke na nwanyi inhibition umu nwoke dara mba, na -eme ka ngosiputa nke ihe mgbaàmà nke oria serotonergic (5-HT syndrome) [18], mgbe ọghara ịbanyeghị ya na anụmanụ anaghị agwụ ike [24]. Yohimbine, onye omekome _2-adrenergic a maara iji rụọ ọrụ biphasic, mmetụta dabere na njiri copulatory nke oke oke [6], nwere windo dị warara maka mmetụta ya na mmekpa ahụ nke agụụ mmekọahụ karịa nke ndị na-adịghị agwụ ike [18], na A na-ahụ mmetụta yiri nke ahụ na ndị opioids antagonists naloxone na naltrexone [19]. N'ikpeazụ, onye na - emegide dopaminergic, haloperidol, na - akpata omume ịkpa ike n'ahụ ụmụ anụmanụ ike gwụrụ na usoro nke enweghị mmetụta dị otú ahụ na oke oke nwere mmekọahụ [17]. N'ozuzu, data ndị a na-egosi na hypersensitivity na omume ọgwụ bụ ihe jikọtara ọnụ nke oke oke nwere mmekọahụ, ebe ọ na-apụta mgbe ịgba ọkụ nke ndị ọrụ ọgwụ dị iche iche na-arụ ọrụ na sistemụ neurotransmitter dị iche iche.
Ya mere, mgbe ndekọ 24 h dechara, ebe ihe fọrọ nke nta ka ọ bụrụ na ọnụ ọgụgụ ndị na-enwe mmekọahụ na-amaliteghachila onwe ha, mmụba na-aga n'ihu na ikike ejaculatory nke oke oke nwere mmekọahụ.
N'ihi ya, 40% nke oke rapaara gosipụtara ruo 3 ejaculations nke abụọ nke 72 h mgbe usoro ike gwụsịrị. Onu ogugu a riri elu karia nke enyerela na 24 h ma belata nke oma ma aturu anya na onodu a riri oke ahuhu nwoke na nwanyi n'oge mmeghari ahu. Ego oke 4 na-aga n’ihu site na oke rats 96 h mgbe satiation gasịrị, ọnụọgụ a bilitere na 5 mgbe oge izu ike 7.
NKWASỊTA
Ihe omuma banyere oge nke nmeghachi omume nke nmekorita nwoke na nwanyi mgbe ekwuputara na nwuo, gosiputara n’aghagharia usoro a ga - agbaso tumadi site na mgbanwe ato: pasent nke oke di iche-iche riri nne na –ezu oke. ikike enwere ike igosipụta oke oke mgbe ezumike dị iche iche. Nsonaazụ gosipụtara n'oge 48 nke mbụ na-eso ntinye obi na nnọkọ ike, ụmụ anụmanụ na-egbochi nke ọma na mmụba, na-abawanye ikike ejaculatory (3 na-esochi agaculations) na oke oke nke rats.Udi oke nke ụmụ nwoke na-egosipụta ụba ejaculatory a. ike a na-eme 72 h mgbe satiation gasịrị. Ka oge izu 96 h zuru ike gbasara anụmanụ, anumanu niile nwere ike itugulite ma bido nwegharia obi mgbe ejupusiri. Nke a bụ mgbanwe nha anya, ebe ekwuru na-eche na nyocha nnwale na-eweghachi ike mmekọahụ bụ mgbake nke ike nke oke oke iji maliteghachi copulation mgbe ejaculation [18] gasịrị. Ya mere, enwere ike ikwu na n'oge a, mmachi mmekọahụ nke na-akọwa satiation bụ nwugharị na anụmanụ niile, bụ nke nwere ike niile iru usoro abụọ na-aga n'ihu. Mgbe oge izu 7 izu ike nke izu ike ikike ejaculatory nke ihe fọrọ nke nta ka ọ bụrụ ụmụ anụmanụ niile na-abawanye ruo 4 na-aga n'ihu agaculations, na 5 mgbe ụbọchị 10 na 6 mgbe ụbọchị 15 izu ike nke mmekọahụ.
Onu ogugu nke oke nwoke tara aru ka ekpughere site na nkpuru nwoke site na nmekorita nke nmekorita (asaa) site na onodu ubochi ndi mmadu site na nmekorita nke nmekorita nke nwoke. Ogologo ikpeazụ a adịghị iche na nke enwetara n'oge nnọkọ na nnọkọ satiation na ụmụ nwoke na-adịghị agwụ ike.
Ọmụmụ mmiri mbụ Beach na Jordan banyere ike mmekọahụ [3] kọrọ oge nke ụbọchị 15 maka mgbake zuru oke site na ike mmekọahụ. nke kpebiri site na nlere na obere oge ole akọwapụtara na-esochi satiati. A nwetara data dị ugbu a site na iji otu oke (ndị nnọchite anya) oke nke oke maka oge ọ bụla nke usoro mgbake ahụ, na-enyocha ikike ejaculatory na nke ọ bụla n'ime isi ihe ndị a na-etinye nkatọ satiation (90 min na-enweghị ejaculating mgbe ejaculation ikpeazụ gasịrị). Ọ dị mma ịmara na, n'agbanyeghị ụdị paradaịs dị iche iche nke agụụ mmekọahụ na-eji na ọmụmụ ihe yana ụzọ iche nke ejiri rụọ ọrụ iji guzosie ike oge inhibitory, otu oghere oge ahụ ka ọ dị mkpa maka mgbake zuru oke. Ego a, yana eziokwu na ọnụọgụ mmachi nke 7 nọchiri anya mmụba na mmụba nke ogologo oge nke post-ejaculatory etiti oge a na-aza na mmechi ike mmekọahụ dị iche iche [3,12,18], na-atụ aro na ndị a bụ isi ihe niile. atụmatụ nke agụụ mmekọahụ na-apụta, na-apụtaghị ihe ọ bụla na-eme ka ọnọdụ a na-egbochi mmadụ.
Ihe akuko nke nmeghari ohuru na ikike izizi ejaculatory nke a kọrọ ebe a bụ data akụkọ nwere ike ịba uru maka nguzobe afọ nke nsonaazụ nke nnwale na-eme ka ngosipụta mmekọahụ dị na oke oke agụụ, yana ikpebi ogo inhibitory ala mbugharị nke mepụtara na oke na-esonyere otu ụdị nnabata anyị.
N'ihe banyere ihe ịtụnanya ọgwụ ọjọọ, nyocha nke ihe ịrịba ama dị iche iche nke 5-HT-syndrome kpughere na FBP bụ akara kacha agbanwe agbanwe nke a hụrụ mgbe achịchara ọgwụ mmachi nke 8-OH-DPAT na oke. Nke a bụkwa akara kacha mma gosipụta ọdịiche ụmụ oke nwere ọnọdụ mmekọahụ.
Dịka e kwuru na mbụ, FBP na ntinye ihu bụ ihe mgbaàmà abụọ ejikọtara na ip nke 8-OH-DPAT na oke oke na-adịghị enwe mmekọahụ, ọ bụ ezie na ọkwa dị elu [10]. Agbanyeghị, na nnwale anyị, akara akara nke pre hore na-apụta naanị na anụmanụ mgbe ụfọdụ, n'adabereghị na ọnọdụ mmekọahụ ha. Nsonaazụ dị iche nwere ike ịdabere na ọkwa dị ala nke agonist 5-HT1A ejiri na nyocha anyị. N'ụzọ na-akpali mmasị, na ọkwa ndị a dị ala, ihe mgbapụta mgbochi mgbochi nke 5-HT syndrome, nke a na-akọpụtaghị na mbụ ga-esite na ntụtụ ip nke 8-OH-DPAT, gosipụtara na ihe fọrọ nke nta ka ọ bụrụ anụmanụ niile nke ọnọdụ mmekọahụ ọ bụla na ihe kpatara ya nwere ike ịbụ. otu, ntụgharị na ọ na - apụta na oke doses, abụghị nwalere n'ọrụ ndị ọzọ. Egosipụta akara FBP gosipụtara ọdịiche dị n’etiti ahụmịzụ nwoke na nwanyị nwere mmekọahụ na agụụ mmekọahụ na-egosipụta nke ọma, mana n’ụzọ na-atọ ụtọ, a ga-enwe ike igosipụta ịdị adị site n’etiti ndagwurụ mmekọahụ na oke oke nwere mmekọahụ.
Ọdịiche nke mmetụta ọgwụ ike n'etiti anụmanụ na sexuallyụ na ụmụ anụmanụ nwere ike gwụrụ nwoke na nwanyị ruru otu ụzọ nke ịdị ukwuu. Ihe ọmụma anyị, nke a bụ ọrụ mbụ na-akọ banyere mmekọahụ na-agbanwe uche nke oke maka omume ọgwụ. Ihe omuma ndi a n’echebara anyi ihe mmetuta nke mmekorita nke nwoke na nwanyi na aru oru n’ime anumanu okenye. N'afọ ndị gara aga, ọtụtụ ọrụ elebarala okwu a anya. Ya mere, anyị nwere ike ịchọta ọrụ na-akọ na ahụmịiko mmekọahụ na-emetụta ihe nzuzo hormone steroid [8,29], na-amụba medial preoptic mpaghara nitric oxide synthase [7], na-agbanwe ọnọdụ na emetụta site na ibelata nchekasị-[8] na omume ịda mbà n'obi [14]; na - eme ka neurogenesis okenye dịkwuo mma na nzaghachi maka isi anụ ahụ [25] ma na - akwalite mgbanwe nkwupụta mkpụrụ ndụ na azụ aka azụ na azụ azụ [5]. Dabere na nsonaazụ nke ọrụ ugbu a, enwere ike ịgbakwunye mmetụ uche ọgwụ na ndepụta nke mgbanwe ogologo oge na ọrụ ụbụrụ na-arụpụta site na ahụmịhe mmekọahụ.
Ọ dị mkpa ịkọwapụta na oke ọgwụ ọjọọ a hụrụ na oke oke nwere mmekọahụ ma ọ bụrụ na e jiri ya tụnyere anụmanụ naïve na-enwe mmekọahụ ga-abụ nsonaazụ nke usoro dị iche karịa nke na-akpata hyperensitivity hụrụ na oke oke.. Nke a bụ, n'ihi na nke mbụ ejikọghị ya na mmekọahụ na nso nso a (oke ndị a nwere mmekọahụ ikpeazụ ha dịkarịa ala ụbọchị 5 tupu ntụtụ 8-OH-DPAT), ebe nke ikpeazu na-egosi n'ụzọ doro anya na copulation na ahụmịja satiation. (vide infra). A pụkwara ịchọpụta ọdịiche dị na 8-OH-DPAT nke ụmụ anụmanụ nwere ahụmịhe na agụụ mmekọahụ na arụmọrụ mmeghari akparamagwa a. Ya mere, ezie na 8-OH-DPAT fọrọ nke nta ka ọ ghara inwe mmetụta na oke oke nwere mmekọahụ, ọ mere ka ihe omume mmekọahụ niile nke oke oke tara akpụ site na ibelata ha, otu usoro onyonyo, yana ịba ụba pasent nke anụmanụ na-agwụ ike ịmaliteghachi azụ mgbe ejaculation gasịrị. Agbanyeghi na ikike nke 8-OH-DPAT iji dochie satiation nmekorita nke nwanyi [18], ugbu a, achoputara mmetụta a na usoro onyonyo dị ala karịa nke ndị mbụ ji eme ihe, na-egosi hypersensitivity nke oke oke agụụ mmekọahụ maka omume ọgwụ. Agbanyeghị, ekwesịrị iburu n’uche na ọnọdụ inhibitory mmekọahụ nke oke oke agụụ nwere ike rụọ ọrụ na-eme ka mmelite 8-OH-DPAT nwee mmezi. A na - ahụkarị ihe ndị na - eme ka nwoke ma ọ bụ nwanyị nwee mmekọahụ na - eme ka ụmụ nwoke nwee mmekọahụ. N'ọnọdụ ọ bụla, mgbe ị na-atụle omume copulatory, ọ gaghị ekwe omume ịmata ọdịiche dị n'etiti ihe mmetụ ọgwụ ọgwụ na nsonaazụ n'ihi ọnọdụ omume mmekọahụ dị iche.
Nyocha nke oge nke hypersensitivity na 8-OHDPAT dị ka ntughari site na nkwupụta FBP na-egosi na ihe omume a dịgidere 72 h na-agbaso usoro satiation, ma ọ fọrọ nke nta ka ọ pụọ na 96 h mgbe akpachara satiation. N'aka nke ozo, mmeghachi omume nke 8-OH-DPAT na omume copulatory nke ụmụ nwoke ike gwụrụ ka dị ugbu a na usoro omume mmekọahụ kpọmkwem akọwapụtara 96 h mgbe usoro satiation ahụ gasịrị. Ọzọ, atumatu nke inhibitory ọnọdụ nke mmekọahụ na mmeghachi omume ndị dị ntakịrị nke 8-OH-DPAT na oke agụụ mmekọahụ na-agụ agụụ. N'ụzọ dị iche, akara FBP nke 5-HT syndrome enweghị ike iju anya na mmetụta mmekọahụ nke usoro satiation n'onwe ya ma gosipụta, yabụ, dị ka njirimara kachasị mma iji gosipụta njirimara nke mgbake site na mmetụta hypersensitivity ọgwụ.
Nyochaa usoro mgbagha azụ nke ihe mgbochi omume mmekọahụ na-esite na ike mmekọahụ yana nke hypersensitivity na 8-OH-DPAT, atule site na ngosipụta FBP, na-ekpughe na ihe ịtụnanya abụọ ahụ na-agbaso n'otu oge. N'ihi ya, mgbe 96 h zuru ike mmekọahụ, a na-atụgharị ihe mgbochi mmekọahụ na anụmanụ niile yana oke nke oke oke na-egosipụta FBP na-adaba na 25%, n'ụzọ dị iche na ihe fọrọ nke nta ka ọ bụrụ 100% nke ha na-egosipụta ihe ịrịba ama nke 5-HT a n'oge 72 nke mbụ satiation Oge mgbakwunye oge a na-agbake na-egosi na ihe abụọ ndị a nwere ike igosipụta ngosipụta dị iche iche nke otu sistemụ arụ ọrụ ụbụrụ. Eziokwu ahụ na oke oke nwere oke elele na-apụ n'anya na-apụ n'anya ụbọchị 4 mgbe ahụmahụ mmekọahụ ikpeazụ gara n'ihu na-akwado echiche ahụ na usoro dị n'okpuru ahụ ga-adị iche na nke na-eweta hypersensitivity na oke oke nwere mmekọahụ, nke ka dị ugbu a ụbọchị 5 mgbe mmekọrịta ikpeazụ ha. Pitchers et al. na nso nso a kọrọ na inwe ahụmịhe nwoke na nwanyị na-ebute mmetụ nke omume na oke oke, nke oke oke nwere mmekọahụ na-egosipụta azịza nzaghachi dị elu na amphetamine ma e jiri ya tụnyere anụmanụ na sexuallyve mmekọahụ [15]. Yiri nke nchọta a na data dị ugbu a pụtara ihe, n'ihi na ịmata omume na-egosi ịba ụba nke ọgwụ / iji ọgwụ ike eme ihe. N'ikwekọ na data dị ugbua nke ụmụ anụmanụ nwere mmekọahụ, e dekọtara akụkọ mmetụ ahụ emere mgbe agaala ugboro ugboro; usoro ana - eme ka otu esi eme ugbu a iji raku oke nwere mmekọahụ, na otu izu mgbe nzukọ ikpeazụ gachara; ihe nlere anya dika oge nke 5 kwere ka anyi nwalee oria 5-HT n’ahu n’ọrụ anyi.
N'ụzọ na-akpali mmasị, Pitchers na ndị ọrụ ibe nwalere nsonaazụ mmụba ugboro ugboro na 7 ụbọchị sochiri n ’amamịghe amamịghe mmetụta amamịghe ma ọ nweghị ọdịiche na nzaghachi ha nwetara mgbe agabigaghị ókè [15]. Ihe omuma a di iche na nchekwube na adighi nkenke banyere 8-OH-DPAT no ebe a maka oke ogu riri oke na nwoke ma aturu ya na anumanu nwere nsogbu nwoke na nwanyi. Uche a nwere ike ịdabere na eziokwu ahụ bụ na n'ọrịa agụụ mmekọahụ na-aga n'ihu ugboro ugboro ejaculation (7 na nkezi) pụtara na obere oge dị mkpirikpi (gburugburu 2.5 h) ma nwee ike ịkpalite usoro iche karịa nke otu ejaculation kwa ụbọchị na 7 ubochi nile. A na-ahụta ihe dị iche na nsonaazụ abụọ ndị a na oge nke hypersensitivity, nke were naanị ụbọchị 3 na oke oke ma bụrụkwa onye e debere ọbụlagodi maka ụbọchị 28 na oke iji raara mgbatị ugboro ugboro na 7 ụbọchị sochiri na Pitchers. ọrụ.
N'uzo, data egosiputara ebe a gosiputara na imeghari otutu mmadu na aru oru oke oke nke umu nwoke, site na iwepu uzo ihe omume ogwu. Copulation to satiation, akpan akpan, na - akpali ma ihe mmetụ ọgwụ ọgwụ na ọnọdụ inhibitory mmekọahụ nke na - apụta ịgbakwunye oge mgbake, na - egosi oke 96 h mgbe satiation mmekọahụ. Enwere ike ịkọwa ihe omume ogologo oge nke ihe omume abụọ ahụ site na mgbanwe nke ụbụrụ plastik ụbụrụ,, n'ụzọ na-atọ ụtọ, ga-eji nwayọọ nwayọọ na-apụ n'anya na-egosipụta ọdịdị ịgbanwe. Enwere ike iche na mgbochi ogologo oge mmekọahụ na-esite na ntinye obi na satiation bụ usoro nchebe pụọ na mkpali nke ụbụrụ ụbụrụ nke na-etinye aka na nhazi ya. Usoro mesolimbic na-ekere òkè na nhazi nke ụgwọ ọrụ ndị sitere n'okike gụnyere omume mmekọahụ [2]. Imukpali akpali nke sekit a site na nchịkwa ọgwụ ugboro ugboro nke ị abuseụ ọgwụ na-eme ka akparamagwa [16] nke yiri oke ọgwụ na-egosipụta oke oke na-egosipụta mmekọahụ mgbe mmesịrị ugboro ugboro na obere oge, nke ga na-akpali usoro mesolimbic ugboro ugboro. [2].
Enwere ike ịkọwa usoro ọmụmụ oge abụọ nke ọgwụ ọjọọ na mgbochi nke mmekọahụ ebe a dị ka ihe akaebe maka omume ha na sistemụ mesolimbic. Ihe omume abụọ a nwere ike ịbụ ngosipụta dị iche iche nke oge gboo, oge dị mkpirikpi, ụbụrụ plastik ụbụrụ iji kpuchido sistemụ mesolimbic site na oke mkpali n'oge nke copulation ruo ike ọgwụgwụ..
A ga-eduzi nyocha ndị ga-eme n'ọdịnihu iji mụọ usoro ndị ga-ekwe omume na-esonye na usoro ahụ na-adọrọ mmasị: ntinye nke mgbanwe na-adịgide adịgide na arụ ọrụ ụbụrụ nke yiri ka ọ ga-agbanwe.
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