Ọrịa Ọrịa. 2015 Mee 7. pic: S0006-3223 (15) 00371-6. doi: 10.1016 / j.biopsych.2015.04.026.
Kim Y1, Simon NW1, Osisi J1, Moghaddam B2.
nkịtị
MGBE:
Lugbanye ụbụrụ neurobiology nke ụbụrụ nwatakịrị bụ ihe dị mkpa n’anyị ịghọta nghọta etiology nke ọrịa ụbụrụ dịka schizophrenia na iri mmadụ ahụ, ihe mgbaàmà nke na-egosipụtakarị n’oge mmepe a. Dopamine neurons na mpaghara ventral tegmental (VTA) nwere mmetụta siri ike na akparamagwa akparamaagwa na nsogbu ọgụgụ isi, mana amachaghị banyere etu ndị ntorobịa VTA dịruru na-etinye ozi n’oge omume.
METHODS:
Anyị na - edekọ kwa ụbọchị site na neirons nke VTA na ụmụ oke na ụmụ oke mgbe a na - amụ ma na - arụ ọrụ dị egwu na mkpochapụ site na ọrụ a.
IHE:
N'oge arụmọrụ nke otu omume ahụ kpaliri, ndị okenye na ndị ntorobịa bụ VTA nechiri mmadụ ụzọ ihe otu ihe ahụ. Ndị akwara VTA dị afọ iri na ụma nwere njiri dopamine enweghị akara ngosipụta atụmanya ma gosipụta azịza dị nta na nnyefe ụgwọ ma e jiri ya tụnyere ndị okenye. Mgbe mkpochapu ha gasị, neurons ndị a nwere nnabata siri ike banyere ihe ndị na-ebu amụma banyere ohere inweta ụgwọ ọrụ.
Nkwenye:
Ihe mmeghari ohuru nke neuronal na VTA na-akwado ntinye uche ma na-egosi na ngbama amuma nke njehie. Ọnụnọ nke ihe omume a, yana ihe nnọchi anya ugboro ugboro nke ahụmịhe nke ụgwọ ọrụ mbụ, nwere ike ịnye usoro maka ịme mkpebi ngwa ngwa na ntorobịa.
Copyright © 2015 Society of Biological Psychiatry. Elsevier Inc. bipụtara. Ikike niile echekwabara.
AKWỤKWỌ:
Nwata; Dopamine; Mkpụkpu; Nkuzi nke oma; Nkwụghachi ụgwọ; Mpaghara okirikiri
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