Neurobiol Mụta Mem. 2016 Dec; 136: 127-138 . doi: 10.1016/j.nlm.2016.10.002. Epub 2016 Ọkt 5.
Baker KD1, Reichelt AC2.
nkịtị
Nsogbu nchegbu na oke ibu bụ ma ndị ntorobịa na ndị ntorobịa. N'agbanyeghị na-arịwanye elu na-egosi na ịṅụbiga mmanya ókè nke oke abụba / nnukwu shuga "junk" na-eduga na nsonaazụ neurocognitive dị njọ, a maghị ntakịrị banyere mmetụta nke nri ndị na-eri nri na ncheta mmetụta uche na ụkpụrụ egwu. N'ime nnwale ndị dị ugbu a, anyị nyochara mmetụta nke oriri 2h kwa ụbọchị nke nri dị oke abụba / shuga (HFHS) n'ofe ntorobịa na mgbochi ụjọ na omume nchegbu na oke oke na-eto eto. Oke ekpughere na nri HFHS gosipụtara njide adịghị mma nke mkpochapụ egwu yana mmụba dị ka nchekasị na nnwale mpụta ma e jiri ya tụnyere oke nyere nri ọkọlọtọ. Oke HFHS na-enye nri gosipụtara mgbanwe nri na-akpata na arụ ọrụ prefrontal cortex (PFC) nke achọpụtara site na mgbanwe mgbanwe nke GABAergic parvalbumin na-egosipụta inhibitory interneurons na ihe ntụgharị ederede kwụsiri ike ΔFosB nke na-agbakọta na PFC na nzaghachi na mkpali na-adịghị ala ala. Nyocha nke immunohistochemical nke medial PFC kpughere na ụmụ anụmanụ na-eri nri HFHS nwere obere mkpụrụ ndụ parvalbumin na-egosipụta na ọkwa dị elu nke okwu FosB / ΔFosB na cortex infralimbic, mpaghara metụtara na nchikota nke ikpochapu egwu. Enwere omume maka ịba ụba nke IBA-1 immunoreactivity, ihe nrịbama nke ịgbalite microglial, na cortex infralimbic mgbe ekpughere nri HFHS mana okwu nke extracellular glycoprotein reelin emetụtaghị ya. Nchọpụta ndị a na-egosi na ihe oriri HFHS n'oge uto na-ejikọta ya na mbelata neurons nke prefrontal parvalbumin na mgbochi egwu egwu n'oge ntorobịa. Mmetụta ọjọọ nke nri HFHS na usoro nke iwu iwu ụjọ nwere ike ịkpalite adịghị ike na ndị buru ibu na mmepe nke nsogbu nchekasị.
AKWỤKWỌ: Oge uto; Mwepu; Ụjọ; Ibu oke ibu; Parvalbumin; Prefrontal cortex
PMID: 27720810
DOI: 10.1016/j.nlm.2016.10.002
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