Nkwupụta: Ndị na-anabata D2 agonists na-ebelata nchekasị
nkịtị
Iji tụnyere ọrụ nke D2-subtype dopaminergic receptors na usoro nke omume nchekasị na oke ụmụ nwanyị na-emebeghị nke ọma n'oge okirikiri ovary na oke ụmụ nwanyị ovariectomized (OVX), mmetụta nke nchịkwa na-adịghị ala ala nke D2-dopaminergic agonist-quinperole (0.1 mg / kg) na Ndị na-anabata D2-dopaminergic antagonist-sulpiride (10.0 mg / kg) gbara ya iche ma ọ bụ yana yana 17beta-es-tradiol (0.5 mcg maka anụmanụ ọ bụla) n'ime ụbọchị 14 na ọnọdụ omume nke ndị okenye na-emebibeghị na ovariectomized (OVX) ụmụ oke ụmụ nwanyị nyochara. A na-enyocha ọkwa nke nchegbu na elu gbakwunyere maze, omume nke ụmụ anụmanụ na-eme atụmatụ na ule oghere oghere. Ekwuputara na nchịkwa na-adịghị ala ala nke sulpiride maka oke na-adịghị emebi emebi butere omume anxiogenic na elu gbakwunyere maze n'akụkụ niile nke okirikiri ovary ma e wezụga proestrous. Nlekọta Quinperole nye oke ndị ahụ na-adịghị emebi emebi nwere mmetụta anxiolytic na omume na elu gbakwunyere maze na ihu igwe, na-eri nri na agụụ. Cnchịkwa quinperole hronic naanị ma ọ bụ yana yana 17beta-estradiol na oke OVX rụpụtara mmetụta anxiolytic na omume na elu gbakwunyere maze. N'ụzọ megidere nke ahụ, nchịkwa sulpiride naanị na oke OVX emeghị ka ọ gbanwee ọkwa nchekasị, ebe na njikọta ya na 17beta-estradiol, egbochiri mmetụta anxiolytic nke ọgwụ hormone kpamkpam. N'ime oghere ule nyocha quinperole na oke OVX mụbara ọrụ locomotor kwụ ọtọ, nyocha na omume ejiji. Ya mere, nsonaazụ enwetara na-atụ aro ọrụ mgbanwe nke D2-subtype dopaminergic anabata na usoro nke omume nchegbu na ahaghị nhata nke estrogen.
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