M. ABDULMAGED TRAISH
Biochemistry et a Dicasteriis Curiæ Urology, Boston University nisl, Boston, MA.
| Catullus to: Marcus Abdulmaged M. Traish, Professor of Biochemistry et Urology, Director, Laboratories ad sexualem medicina honoribus Institute for sexualem medicina honoribus Boston University nisl: Centrum pro Research Lorem Advanced: 700 Albaniae Sancti, W607, Boston, MA 02118 ( e-mail: [Inscriptio protected]). |
| Publication enim accepistis 13 Iunii, 2008; quia publication 17 Septembris accepit, 2008. |
Abstract
Androgens necessaria progressionem, incrementum: et compages maintenanceof penis, ex physiologia et ordinare sufficienter erectile multiplemechanisms. Hic praebere volumus, brevis overview de androgen basicresearch inventa pertinens ad similitudinem modulatis erectiletissue architectura et physiologiam. A significant corpus evidenceexists demonstrato discrimine partes in androgens erectilephysiology. Animalis studiis, in exempla monstrabit, provisum est ut scientia fundamental in partes androgens in modulating TEXTUS architectureand cellular: hypothetica, et phjsiologica S machinationes. Basedon de notitia elit et relata ab aliis, webelieve androgens qui munere funguntur atque munus in obtinendo thestructure peripheralium nervi network penis et integritas: sistens descriptiones corporum caver- et tunicaalbuginea et endothelium spatia in antro. Praeterea, androgens ludere magna munus in in regenda hominis vita differentiationof praecursorem lenis musculus cellulis in trabecular. Huic recenseo, nos focus in disputationem nostram ab androgens therole inventa est in regula pertinens architecturalelements penile textus munus in penis modulantes. Et hoc videtur scientia hasa potentiale labefactum in usus tractare de aegris cum androgens in clinicalsetting ad Praesent.
Key words: andropause, Praesent, hormone, tuoque pene infesto adipogenesis: androgen defectus, corpus cavernosum, venerem agendo, lenis musculus
|
Praesent sit amet est causa, veno Corporeal occlusive oforganic Praesent rates atque distinctum est ponere fluxus needfor auctus per erectionem erectionem clinicalevaluation autem per infusionem intracavernous SAL (al Hatzichristouet, 1995, 1999; Et al Nehra, 1996, 1998; Et al Udelson, 1998; Et al Mulhall, 2004). Corporeal veno occlusive dysfunctionalone, sive collegiatas et arteriarum morbus est propria causa hemodynamicabnormality indigentiam responsionem intracavernous Pharmacotherapy (Et al Rajfer, 1988; Et al Mulhall, 1997; Aversa institui potest, 2003;Et al Wespes, 2005; Et al Hwang, 2006). Quod concomitantarterial lenis musculus et sinus facit morbo-veno occlusivedysfunction saepe diffice est egritudo et tractare.
Licet nisus fuisset in multis factus est intellegere, et per partes laboratoriesto define androgens ex erectile munus in regulatingthe et hypothetica et cellularum someprogress dictum est, pluribus hiatus manent. Haec includethe androgens partes in structura et munus ad integrityof cavernosal, dorsalium, in qua absolvi et functionof lenis musculus coetus, itemque munus et metabolismi et nota TEXTUS Domini endothelium andmaintenance attenuationof fibrosis. Hic opus est ut sisterent de androgen actionin erectile munus exemplar (figure 2). Compage usus est, wediscuss in partes androgens in penis components: sistens descriptiones inter 1) periphericis nervorum, 2) trabecular lenis musculus, 3) differentia, praecursionis pluripotent smoothmuscle in ergastulum: 4) endothelium venosi sunt, et 5) tunica albuginea andconnective TEXTUS.
|
Androgens flectentes structuram et function gangliorum depen- de pelvis (Et Meusburger Keast, 2001; Et al Keast, 2002). Asta lulianus et al (2004) Androgens synphoniae dicuntur, ut suggesserant erectile functionby postganglionic of rectum agens de neurons. Armaganet al (2007) Ostendit, quod ad structuram de androgen privatio per castrationaltered salis. Hoc factum est ab illis cum observationibus editi sunt consistent Baba et al (2000a,b) In whichcastration reducitur in cavernosal NADPH tenuibus nerui et dorsalnerves fibersto potestate haec restaurata curatio et testosterone campester. Rogers et al (2003) Et altera: et compages thatcastration demonstratum est venosus dorsalis resultedin et ultrices. Testosterone curatio statim post idem rursus restaurata, et prohibitus sum venarum ultrices intracavernosalpressure values similis ei de illa animalia integrum. Interestingly, curatio de animalibus sunt castrati libidinis abolendae causa vascularium endothelial growthfactor (VEGF) restaurata nervum et in structuram, veno occlusive function.Because androgens sunt VEGF ostensum est moderari (cf.Et al Haggestrom, 1999), Fieri potest, ut corpus cavernosum VEGF synthesisin sunt, ordinata sunt castrati libidinis abolendae causa est animalsand persuadet uti testosterone VEGF summa curatio, effectus dependens in corpus cavernosum-sicut mediatingthe androgen.
Orchiectomy produci actus elicitus a signanter reductionem in intracavernosalpressure electrica titillatione in agro pelvicnerve. Ut extenderent manum contra hoc postea in testosterone, testosterone suggestingthat lascivio an maximus persona in network peripheralnerve regendo praeesset penis (Simpson, et Marescallus 1908; Et al Graecorum, 1988; Heton, et Varrin, 1994; Et al frangebat mola, 1994; Et al Bivalacqua, 1998; Et al Traish, 1999; Et al palese, 2003; Suzuki et al, 2007). Praeterea, Suzuki et al (2007) Demonstratedthat in comparatione ad actus elicitus a respondeo erectile electricalstimulation cavernosal ex neruo tamen qui non abstulit butwere facti sunt castrati libidinis abolendae causa in animalibus erectile responseselicited per electrica titillatione in media preoptic areawere eliminated hoc idem rursus esset: et postea plene restoredafter testosterone.
Esse androgens Penile trabecular venenum blanda musculus structuram et function
Multiplex haec navitas quod existit nihil ad musculus papillaris trabecularsmooth ludit partes integralis in regendis erectilefunction (Saenz de Tejada 2002). Ad tertium themolecular et fabrica mutationes, quae in ratione posterior ea quae smoothmuscle androgen defectus autem manet ignotum.
In androgen privatio exempla monstrabit, animalis, per seu extractionem chirurgicam medicalcastration, produci signanter reductionem in trabecular smoothmuscle content, auctus, et nuncii depositionem extracellular connectivetissue xxii (xEt al Traish, 1999). Haec mutatio per tissuearchitecture est consociata cum pressura reductionem in intracavernosal in responsione ad pelvis nervi excitanda (Simpson, et Marescallus 1908; Et al Graecorum, 1988; Et al Takahashi, 1991; Heton, et Varrin, 1994; Et al frangebat mola, 1994; Et al Bivalacqua, 1998; Et al Traish,1999, 2003; Et al palese, 2003; Suzuki et al, 2007). Ceterum in studiis ultrastructural lenis musculus TEXTUS ex castrati libidinis abolendae causa trabecular documentedthat animalia apparuit multitudinem indigestam et universi generis cytoplasmic vacuolae et minuitur copia cytoplasmic myofilaments (Et al Persson: 1989; Kim et Traish, 2005;Et Traish Guay, 2006; Et al Traish, 2007). Smoothmuscle damna inde privatio sit de androgen attribuitur munerum incremento in cellula programmed mors, nota TEXTUS depositione scripto redegit, et Adipocito differentia a precursor (cellulae calciEt al Shabsigh, 1998; Et al Traish, 2005). Quidam features insignes conversiones in penis tissuestructural nuntiavit in aegris cum erectile dysfunctionwere extracellularmatrix lenis musculus ATROPHIA et congeriem, constat praesertim ex fibrillis collagen.
Et lenis musculus TEXTUS nota cum contentus de corporum caver- relativeto appositis, taxata per histologically specificstaining, is defined sicut lenis musculus tissueratio nota est. A contentus decrescit in ratione trabecular lenis musculus TEXTUS concomitantwith auctus depositionis nota TEXTUS frugibus praesentis expectedto vulvam generis masculini, et tandem fibrosis erectile dysfunction.The severitatem symptoms Volume Inventiones, et est apud homines erectiledysfunction connectuntur cum imminutos contentus de corporalsmooth musculus TEXTUS (Nehra institui potest, 1996, 1998; Et al Wespes, 1997, 1998). ED homines in carne et musculus glycogen particlesand aggregata mitochondria exhibitedaltered morsa accidens invenitur cellulis sparsis. Sicque formabis nucleos-cellula in cellulam, et figura ostendi pleomorphic contactswere retardando eliminated. Haec studia suggested thatincreased collagen contentus (eg, nota TEXTUS) de compensatory concomitantwith declines in trabecular lenis musculus papillaris contentalters fibroelastic proprietatibus, reduces obsequio et eventus reducitur in penis et effundatur sanguis, producendo Praesent (Et al Persson: 1989; Et al Mersdorf, 1991).
Musculus cellulis in trabecular venenum blanda androgens Regulate differentiatio pluripotent Praecursoris
Forma in animali effecit egestas Androgen accumulationof adipocytes penis textuum subtunicalregion praesertim (Et al Traish, 2005). Testosterone restorednormal cavernosal histological speciem tortor. Tissuealterations observati sunt nervi excitanda pelvis cum pressurefollowing intracavernosal minuatur. Nos autem et alii notedthe cumulus adipocytes in penile textus diabeticanimals (Kim et Traish 2005; Et al Kovanecz, 2006). Quia consociata cum diabete qui ibant et androgen circulationem, quod est probabile huiusmodi est, ab adipocytes congeriem damnum de androgen imperium cellular diversificantur. Et similiter curatio masculus de animalibus cum bisphenol A, quod est operatio estrogenic fadem possidendam, et apud homines in corporum caver- accumulationof adipocytes (al et lunam, 2001, 2004) This suadeat ut estrogens infestas actionin androgen in cellulis in corpus cavernosum, et ex hoc diversificantur precursorpluripotent adipocytes. Goyal et al (2005a,b; 2007a,b) Eleganter enim demonstratum est curatio de 2-die-vetus animalswith estrogens levelsand testosterone homines in congregatione adipocytes plasma reduci ad eumdem corporum caver- animalis perfecti. Bhasin et al (2003), Ut suggesserant androgens generis moderari stimulos inhibere diversae diversificantur in adipocytes pluripotent cellulis in muscleand lenis. Hoc suffulti hypothesiswas adhuc inventa Singh et al (2003, 2006) Demonstratum est, qui sunt diversae in pluripotentcells lenis musculus et inhibitionis de adipogenesis areandrogen-dependens. Nos autem facto cumulus adipocytesin interface inter corpora conferunt cavernosal corporo, et tunica albuginea occlusive Praesent.
Esse androgens vascularium endothelial Graecorum et Romanorum Function
Tum quod statutum est a vascularium lenis musculus sono endothelium modulatescorpus cavernosum NO andparacrine per productionem utriusque, ut prostaglandins, Endothelin, platelet-factor derivedgrowth et Stromelysin β1 [β1, TGF] (Moreland, 2000; Et al Bivalacqua, 2003, 2005; Et al Salomonis, 2003: Guay 2005, 2007; Musicki and Burnet, 2007; Et al Cicero, 2007) .Various contumelias omnium endothelium (id est, ischemia, hypoxia, et ARTERIOSCLEROSIS) auctus esse potest, vel decreasedlevel de paracrine producendum res, et palmam movet munus et growthof lenis musculus cellulis (Moreland, 2000). A recens studio byLu et al (2007) Demonstratum est privatio androgen in castrationor 5
curatio in damnum productum -reductase precursor endotheliumstructure, ut determinari per terrestre. De animalibus endotheliumfrom integrum edidit regularultrastructural cum lenis superficie features. Et ex castrati libidinis abolendae causa endothelium animalshad tumentiore durus et sartatecta faciebant: et visus est irregular.The cellula-cell contactus varietur atque ^ cipuus est rufus erat endothelium bloodcells superficies ad attendendum. Administrationof testosterone castrati libidinis abolendae causa in animalibus ex parte integritas restaurata endothelialstructural cum paucis reliquis vitiis, ut suggesserant noticeable.The studio notitia de hoc androgen deficiencyproduces vascularium endothelial dampnum et endothelial structuralintegrity restaurata est ab administratione androgen. Akishitaet al (2007) Referunt: passus, in mensuram fluxus outpatientswho 187 continuati masculum-mediata vasodilation (FMD) ab usura ultrasonography ulnaris, et freetestosterone sunt significantly connectuntur cum cento totalis FMD. Liberum relatio aetate corpus massa index hypertension, hyperlipidemia, diabete Mellitus ac fumantis suggestinga endogena testosterone in tutela effectus endothelium.
Et vestibulum molestie lacus vel restitutio endothelial injuriam pendeat, partim in stagnum enim de immatura grassentur genitore suo cellulis (quam at pede) et progenitoris mature grassentur endothelial cellulis (EPCs) .Foresta et al (2006, 2008) Cognita autem prolongedtestosterone Lorem effectus est in hominibus, et cum PCs hypogonadotropic hypogonadismon EPCs. De auctoribus, ut suggesserant hypogonadal patientshad reductae campester of testosterone et therapyresulted EPCs PCs et signanter augmentum in his cellulis. Et authorsconcluded Angiokeratoma Corporis, quod est cum PCs redigo circulens et numbersof EPCs. Incrementum maximam, migrationes et educatio colonorum industria EPCs inductus sternat androgens est mediata AR (Et al Foresta, 2008).
Ut, premissis veris existentibus, adductus injuriam toendothelial androgen defectu pene cellula enascentia vascularium lectum increasessynthesis ex firmis et releuijs, TGF β1, Endothelin et contractileprostanoids et decrescit n. Quod talis exitus ad biologicalinsults endothelium non potest immutare thesmooth musculus sexualium phaenotypo ducens auctus extracellularmatrix depositiones (fibrosis) cell ATROPHIA, et inhibitionof incrementum cellula (hypoplasia). Fibrosis ergo nunc mutata est ut contributeto contractility obsequio et minuitur (ut determinedclinically), ducens ad vasculogenic Praesent.
Esse androgens tunica albuginea integritatem compagem et nota TEXTUS Matrix Fibroelastic Properties
Shen et al (2003) Demonstratum, castrati libidinis abolendae causa in animalibus et in crassitudine significantreduction de tunica albuginea comparedwith integrum cum animalibus. Integrum in animalibus est tunica fibris elasticis richin et fibris showedtypical architectura tam regularibus constitutis. Contra animalia docuit apellatur albugineafrom castrensibus reducitur elater fibersand densitas illas postea in collagen. Et authorsconcluded androgens, quae necessaria habentur ad normalis maintenanceof Fusarium oxysporum de penis tunica albuginea.
Androgen per ablationem exempla monstrabit, idem rursus animalis produci amarked incremento in in extracellular vulvam masculini est, in concomitantreduction lenis musculus TEXTUS Ratio est nota per j triplicem statuit approximately2 (Et al Takahashi, 1991; Et al Traish, 1999, 2003) This minui TEXTUS fibroelastic proprietatibus compromisespenile TEXTUS obsequio Vertebrata penis et de dupla sesquitertia, unde fit Praesent (Wespes institui potest, 1990, 1991: Jevtich, 1991; Et al Nehra, 1996). Plures studiis suggestedthat androgens flectentes cellular matrix expressionof per augmentum factores (Et al Natoli, 2005). Hic autem non amplius needto earum in penile textus. Et ita tardius minorabitur in fibris elasticis microscopicae mutationes in features ut contributeto Praesent a fraterna vitia venoocclusive functionof autem tunica albuginea (Et al Ethnici disputantium, 1996; Et al Akkus, 1997) .Recent casus in appositione corroboravimus restitutio de studiis ad homines in erectilefunction Praesent attribuitur venousleakage androgen post curatio (Et al Yassin, 2006; Et al Kurbatov, 2008a,b). Hae observationes suadeant ut androgensplay enim erectile munus in obtinendo TEXTUS architectura.
Et libertate § summary
Ad quod non parum est quod corporis exstat, quod nempe in androgensregulate in structuram et function in penile nervi et vascularendothelium, trabecular lenis musculus, nota TEXTUS vulvam masculini et tunica albuginea. Praeterea, ordinare androgens differentiationof praecursorem cellulis in trabecular lenis musculus et inhibitdifferentiation in adipocytes. In homines: androgen deficiencymanifests orci in ipso quaslibet pathologias, ut 1) et insufficiens development recta plaga coles 2) erectile munus damnum est non benigna prostatic inpeccabilis cum prostate cancer medicinae vel chirurgicam hyperplasiamanaged in curatione feminam inire, vel antiandrogentherapy. In androgen suppletionem hypogonadal aegris improvessexual munus. Hi orci observationes, una notitia withthe Preclinical: suadeant quod testosterone in montem Domini TEXTUS odoris melioris: sistens descriptiones elementa Vertebrata penis.
|
In summary, androgens munere funguntur conservanda erectiletissue in architectura (figure 3), Et physiologia erectile munus neural bymodulating penis in integrityof lenis musculus et structurarum notis, endothelium et nota TEXTUS vulvam generis, tum quod significat metabolicae meatus.
Acknowledgments
footnote
Hoc est comparentia ad speciale in charta fundatur Symposiumon Aprilis XII, MMVIII: "Male de therapeutica Strategies Sexualand hormonal Salutem," consociata cum American Societyof Andrology Annual, cuius authorreceived honorarium sistit.
Marcus Traish habet consulting et / vel financial relationes withBayer AG.
References
Akishita M, Hashimoto M, N Ohike, Ogawa S: Iijima K, M Eto: Y La Ouchi testosterone campester est independens determinans endothelial in agendo homines. Res Hypertens. 2007; 30: 1029 -1034.[CrossRef][Medline]
E Akkus, Portitorem S, Baba K, Hsu vidua, Padma David, H, L Nunes, FG Lue. Structural mutationes in tunica albuginea recta plaga coles: impulsum Peyronie scriptor morbo, senescit et impotentiam. J Urol. 1997; 79: 47 -53.[Medline]
Jeps KE, Volume Beethoven G. de penis senatus censuit. Psalm physiol. 1995; 75: 191 -236.[Liber Full Text]
Armagan A, K Hatsushi, Toselli P. spirit effectus testosterone ex defectu membrorum integritas in penis salis rat. Int J impot Res. 2007; 20: 73 -78.[CrossRef][Medline]
Aversa A, Isidori AM, Noctis G, Lenzi A, Fabbri A. androgens vasodilation mugire domum, et responsum est amplio in aegris cum Sildenafil Praesent. Clin Endocrinol (Ox). 2003; 58: 632 -638.[CrossRef][Medline]
Imago K, M Yajima, Portitorem S, E Akkus, J Reman, Nunes L. Lue TF, Iwamoto M. Effectus of testosterone in numero NADPH diaphorase luctusque cruenti fibrarum nervearum in corpus cavernosum, et salis rat. Urology. 2000a: 56: 533 -538.[CrossRef][Medline]
Imago K, M Yajima, Portitorem S, M. Morgan, L. Nunes, Lue TF, Iwamoto C. moram testosterone postea restituit nitric cadmiae synthase-rat in quibus fibris nerveis, et erectile responsum videtur. Int BJU. 2000b: 85: 953 -958.[CrossRef][Medline]
S Bhasin Sociorum Treuttel NOS Singh R: Artaza J, Sinha Hikim-I, R Jasuja Choi H-Gonzalez Cadavid NF. In androgen dubie, viae effectus in corpus compositionem, mesenchymal pluripotent cellula ut in scopum actiones de androgen. J Gerontol. 2003; 58: M1103 -M1110.
Bivalacqua TJ, Musicki B, L Usta tuus Fortis C, Kadowitz PJ, AL Burnet, Thomas Hellstrom. Endothelial nitric cadmiae synthase gene Lorem ad Praesent. De Curr pharm. 2005; 11: 4059 -4067.[CrossRef][Medline]
Bivalacqua TJ, Rajasekaran M tuus Fortis C, R Wang, Sikka SC Kadowitz PJ, J. Hellstrom. Rursus in penis auctoritate inducta pharmacologically sequuti felis. J Androl. 1998; 19: 551 -557.[Abstract /Liber Full Text]
Bivalacqua TJ, Usta M. tuus Fortis C, Kadowitz PJ, J. Hellstrom. Praesent Praesent in endothelial: endothelium in erectile munus ex physiologia et morbo. J Androl. 2003; 24 (suppl 6) S17 -S37.[Liber Full Text]
Foresta C, N Caretta, Lana A: I. De Toni, Biagioli A, A Ferlin, Garolla A. Reducitur genitore suo numero rotunditatem endothelial cellulis hypogonadal hominum. J Clin Endocrinol Metab. 2006; 91: 4599 -4602.[Abstract /Liber Full Text]
Foresta C, D Zuccarello: De Toni L. Garolla A, N Caretta, Ferlin A. androgens stimulate endothelial cellulis, per genitorem devium ducit ad androgen receptor-mediatae. Clin Endocrinol (Ox). 2008; 68: 284 -289.[Medline]
V Ethnici disputantium, Modesti A, La Pera rebus divinis perfectis G, F Vasaturo, Modica A: G Prigiotti, De Silverio F, Scarpa S. ultrastructural immunohistochemical et talis viros qui sunt in tunica albuginea Peyronie scriptor morbus-occlusive veno et Praesent. J Androl. 1996; 17: 96 -103.[Abstract /Liber Full Text]
Asta lulianus F, Tostain J, Rossi D. Testosterone masculum et libidinis: basic investigationis notitia et orci. Prag Urol. 2004; 14: 783 -790.[Medline]
Goyal UIS Braden TD, Cooke PS: Szewczykowski MA, CS Williams, Dalvi P, J. Williams. Estrogen estrogen-receptor alpha medium inducible abnormitates in developing videtur. Reproduction. 2007a; 133: 1057 -1067.[Abstract /Liber Full Text]
Goyal UIS Braden TD, CS Williams, Dalvi P, M Mansour, J. Williams. Estrogen-rat adductus abnormes cumulus adipem cellulis in penis et consociata damnum fecunditatis pendeat a penis estrogen orci in discrimine tempus progressionem. Sci Toxicol. 2005a; 87: 242 -254.[Abstract /Liber Full Text]
Goyal UIS Braden TD, CS Williams, Dalvi P, M Mansour, J. Williams. INDUCTIO UNIUS circumfundo abnormitates permanent etiam in cole interdum textum muscularem striatum et penis in adulta neonatally tractata sunt mures inclusi essent et diethylstilbestrol valerate estradiol, qui iamiam terminantur, responsum studium. J Androl. 2005b; 26: 32 -43.[Abstract /Liber Full Text]
Goyal UIS Braden TD, CS Williams, J. Williams. Munus estrogen in penis dysmorphogenesis inductione, per recensionem. Reproduction. 2007b; 134: 199 -208.[Abstract /Liber Full Text]
Guay AT. Praesent endothelial cellam munus in relatione: quia curatio effectus. J am Cardiol. 2005; 96: 52M -56M.[Medline]
Guay AT. ED2: endothelial = Praesent Praesent. N am Endocrinol Metab Clin. 2007; 36: 453 -463.[CrossRef][Medline]
Haggestrom S: Lissbrant SI Bergh 'A, E Damber. Testosterone inducit vascularium endothelial incrementum factor in compositionem ventrali, in castrati libidinis abolendae causa prostate mures inclusi essent. J Urol. 1999; 161: 1620 -1625.[CrossRef][Medline]
Hatzichristou D, K Hatzimouratidis, Apostolidis A, Ioannidis E, K Yannakoyorgos, Kalinderis Hemodynamic A. ratione muneris a erectionem pertinentibus. Arteriae et corporalia munus occlusive veno-positive in aegris cum iniectio intracavernosal test. Eur Urol. 1999; 36: 60 -67.[CrossRef][Medline]
Hatzichristou DG Saenz de Tejada Ego Kupferman S, S Namburi, pescatori ES, Udelson D, vivo in arcum ecliptice EN I. lenis musculus sono trabecular iudicis taxationem, per applicationem ad pharmacocavernosometry et analysis de pressura intracavernous determinantes. J Urol. 1995; 153: 1126 -1135.[CrossRef][Medline]
JP Heton, Varrin VIII. De exogenous et effectus idem rursus testosterone suppletionem per penis animalis exemplar a erectionem pertinentibus. J Urol. 1994: 151: 797 -800.[Medline]
Hwang TI Chen HE Tsai FG, Lin YC. Morbi uti androgen et sildenafil pro aegris hypogonadal male gratus et ad Sildenafil solus. Int J impot Res. 2006; 18: 400 -404.[CrossRef][Medline]
Jevtich M, NY Khawand, Vidic B. de C. significationem ultrastructural caver- normalis Inventiones in corpus neque infirmo hominum. J Urol. 1990: 143: 289 -293.[Medline]
Keast M, Marcus Tullius Gleeson, Shulkes A, John Morris. Ac in tutela effectus Maturational terminatio of testosterone et neuropeptide expressio ad axon density rat vas deferens. Neuroscience. 2002; 112: 391 -398.[CrossRef][Medline]
Kovanecz Ego Ferrini mg, D Vernet, Nolazco G, J Rajfer, Gonzalez, Cadavid NF. Pioglitazone facit corporalem veno occlusive distemperantia, ex in exemplum rat genus 2 diabete Mellitus. Int BJU. 2006; 98: 116 -124.[CrossRef][Medline]
Marcus Tullius Krane, arcum ecliptice EN EGO, Saenz de Tejada I. impotentiam. Best J Med N. 1989: 321: 1648 -1659.[Medline]
Kurbatov D, Kuznetsky J, Traish A. Testosterone improves erectile munus in aegris cum hypogonadal venarum ultrices. J Androl. 2008a; 29 (6) 630 -637.[Abstract /Liber Full Text]
Kurbatov DG Kuznetsky yy, Kitaev SV, VA Brusensky. RMN quasi potentiale visualization tool pro venarum objective in aegris cum veno, ultrices occlusive Praesent. Int J impot Res. 2008b: 20: 192 -198.[CrossRef][Medline]
Lu YL, Kuang Domino, Zhu H, B Wu Wang XF, ANGOR YP Wang MA Yu DL. Mutationes in in masculum mures inclusi essent post ostium endothelium Fusarium oxysporum curatione feminam inire, replacement of testosterone et administrationis 5alpha Matrix-vulgare. Asian J Androl. 2007; 9: 843 -847.[CrossRef][Medline]
Lue TF, Tanagho ea. Opera loci laxamento pharmacological administratione impotentiae. J Urol. 1987; 137: 829 -836.[Medline]
A Mersdorf, Aurifaber PC, Diederichs W, Padula CA, Lue TF, Fishman usores IJ, Tanagho ea. Ultrastructural mutat TEXTUS penis in Lystris: collatio 65 de aegris. J Urol. 1991; 145: 749 -758.[Medline]
Meusburger M., JR Keast. Testosterone et nervi augmentum factor est distincta expressio sed interacting effectus in structuram et neurotransmitter adulta peli ^ e ganglio cellula in vitro. Neuroscience. 2001; 108: 331 -340.[CrossRef][Medline]
TM frangebat mola, Stopper VS, Wiedmeier VI. Et postea idem rursus effectis androgen in Vertebrata erigendam in penis of rat. Gen Reprod. 1994; 51: 234 -238.[Abstract]
Lunae autem DG eft KC Lee, Kim YW, HS Park, Cho HY, Kim DD. Est effectus in corpus cavernosum TCDD histology lenis musculus et physiologiam. Int J impot Res. 2004: 16: 224 -230.[CrossRef][Medline]
Lunam DG, Elvira Song: Kim YS, CREO J, Kim DD. Bisphenol A vetat obscura penis per erectionem pertinentibus mutationem histology in vulpe, leporem. Int J impot Res. 2001: 13: 309 -316.[CrossRef][Medline]
RB Moreland. Praesent ab Vicipaedia: trabecular structuram et function ex collationibus magis plebis et in partes muneris acerbius leniusue egerunt. Int J impot Res. 2000; 12 (suppl 4) S39 -S46.[CrossRef][Medline]
Mulhall JP, Thetis M, Traish AM, Gupta S: Park K, P Salimpour, Payton TR, Marcus Tullius Krane, Intracavernosal forskolin arcum ecliptice EN III: De administratione partes vasculogenic impotentiam-repugnant vexillum 3 Pharmacotherapy agente. J Urol. 1997; 158: 1752 -1758.[CrossRef][Medline]
Mulhall JP, M Anderson, M. Parker Congruence veno inter parametris in dynamic-occlusive cavernosometry infusio: opus cavernosography aestimares. Int J impot Res. 2004; 16: 146 -149.[CrossRef][Medline]
S. Graecorum, Hsieh JT, Lue TF, Tanagho ea. Idem rursus et senatus censuit. An animalis studiis. Eur Urol. 1988; 15 (1, 2) 118 -124.[Medline]
Musicki B, Iulius iniuria. Praesent endothelial diabetic Praesent. Int J impot Res. 2007; 19: 129 -1138.[CrossRef][Medline]
Natoli tota AK factum, Credo librarum turonensium Ahimastos supra strictamque aciem, BG, Thearle Song: Marcus Tullius Dilley, Kingwell BA. Ostium aortae lenis musculus cell vulvam generis hominum sexus steroids flectere dapibus depositio Matrix expressio. hypertension. 2005; 46: 1129 -1134.[Abstract /Liber Full Text]
Nehra A Azadzoi KM Moreland RB Pabby A Siroky MB Krane RJ, ecliptice ego Udelson quae mechanica vires praedicat D. Cavernosal Expandability erectile est forma animalis trabecular Histology vasculogenic Praesent. J Urol. 1998; 159: 2229 -2236.[CrossRef][Medline]
A Nehra, arcum ecliptice EN EGO, Pabby A, M Nugent, Huang YH, Morenas memorabilia de incolis A, Marcus Tullius Krane, Udelson D, Saenz de Tejada Ego Moreland RB. Machinas venarum ultrices: Aequa relatio ad futurum clinicopathological corporalis munus et compages. J Urol. 1996; 156: 1320 -1329.[CrossRef][Medline]
Palese MA, Crone adversissimas haud XXIII, Iulius iniuria. A mus exemplar generum trium: villaticae et Praesent. J Androl. 2003; 24: 699 -1703.[Abstract /Liber Full Text]
Persson C, Diederichs W, Lue FG, Yen diligentius fiat, Fishman usores IJ, Mclin P: Tanagho ea. Fusarium oxysporum penis et arteria mutatae vestrae de ratione iudicium orci. J Urol. 1989; 142: 1462 -1468.[Medline]
J Rajfer, Rosciszewski A, ultrices venarum in corporibus Mehringer M. Invaluisset hominum languentium. J Urol. 1988; 140: 69 -71.[Medline]
Tacitus Rs: Graziottin TM, Lin CM, YW Kan, Lue T. Intracavernosal vascularium endothelial incrementum elementum (VEGF) iniectio adeno-mediata VEGF consociata virus gene Lorem, Praesent in venogenic ne vicissim et mures inclusi essent. Int J impot Res. 2003; 15: 26 -37.[CrossRef][Medline]
M. Saenz de Tejada I. lenis musculus papillaris contractility machinationes pro merito semper fecisse. Int J impot Res. 2002; 14 (suppl 1) S6 -S10.[CrossRef][Medline]
Saenz de me Tejada Carson MP, & de Morenas A, arcum ecliptice EN EGO, Traish AM. Kininogen: localization, summa, actio et receptor generis humani penis in corpus cavernosum. J am physiol. 1991a; 261 (v 4 2) H1078 -H1085.[Medline]
Saenz de Tejada Ego Moroukian P: J Filium quoque Virginis, Kim JJ arcum ecliptice EN EGO, Frohrib D. trabecular modulatur ipsa? Capacitor lenis musculus munus in virgam. Studies in lepus exemplar J am physiol., 1991b; 260 (v 5 2) H1590 -H1595.[Medline]
R Shabsigh, Raymond C., CA Olsson: O'Toole K, R. Buttyan Androgen inductio rat DNA synthesis est in virgam. Urology. 1998; 52: 723 -728.[CrossRef][Medline]
Inter Sen ZJ, Zhou XI, Lu YL, Chen ZD. Fusarium oxysporum penis supra modum de androgen privatio. Asian J Androl. 2003; 5: 33 -36.[Medline]
Simpson S Marescallo FHA occurrat. Ab effectis ad causas aptior nervi erigentes in animalibus castrati libidinis abolendae causa. QJ physiol Exp. 1908; 1: 257 -259.[Liber Full Text]
R Singh, Artaza JN Sociorum Treuttel NOS M Deut: X Yuan, Gonzalez, Cadavid NF, Bhasin S. Testosterone vetat obscura adipogenic vero in 3T3 L1-cellam: eaeque nuclei Translocación de androgen receptor cum universa beta-T-cell catenin et elementum ut 4 canonicam ad bypass Wnt signaling sunt transcribenda, moderari adipogenic factors. Endocrinology. 2006; 147: 141 -154.[Abstract /Liber Full Text]
R Singh, Artaza JN Sociorum Treuttel NOS-Gonzalez Cadavid NF, Bhasin S. androgens stimulate et inhibere adipogenesis in myogenic differentia C3H 10T1 / 2 pluripotent per cellulas autem devium ducit ad androgen receptor-mediatae. Endocrinology. 2003; 144: 5081 -5088.[Abstract /Liber Full Text]
Ii quoque, homo C. Jackson G. Erectile dysfunction cardiovascular et patientes: endothelial Praesent sit commune denominator. Cor. 2003: 89: 251 -253.[Abstract /Liber Full Text]
Renault N, N Sato, Hisasue S, R Kato, Suzuki K, T Tsukamoto effectus electrica titillatione elici testosterone in intracavernous pressura maiorem preoptic concavitate nervi in spatio et in masculum mures inclusi essent. J Androl. 2007: 28: 218 -222.[Abstract /Liber Full Text]
Ego Takahashi, Hirata N, S Yokoyama, Ishii N, L Nunes, Lue TF, Tanagho ea. De penis erectile damnum responsio ad intracavernous acetylcholine in infusione canis castrati libidinis abolendae causa. J Hanawa med Exp. 1991; 163: 85 -91.[Medline]
A Traish, N. Quoniam Kim physiologica partes androgens in penis novitiatus erectio, temperatione corpus cavernosum structuram et function. J Sex Med.. 2005: 2: 759 -770.[CrossRef][Medline]
Traish AM, arcum ecliptice EN EGO, Kim Nullum adhibeat NN. Erectile munus et testosterone, a basic investigationis in a orci et androgen exemplar pro administrandi hominibus non sufficere et Praesent. Eur Urol. 2007; 52: 54 -70.[CrossRef][Medline]
Traish AM, Guay AT. Androgens sunt critica pro vorare penis per homines? Preclinical quod in scrutandis et orci. Sex med J. 2006: 3: 382 -404.[Medline]
Traish AM, Munarriz R: Jerome L. S Choi, Kim SE, Kim et N., Huang YH, arcum ecliptice EN I. Effectus medicae et chirurgicam in curatione feminam inire erectile munus per exemplar animalis. J Androl. 2003; 24: 381 -387.[Abstract /Liber Full Text]
Traish AM, Park V, V Dhir, Kim N. Moreland RB: I. Effectus arcum ecliptice EN erectile munus in in curatione feminam inire, et postea androgen lepus exemplar. Endocrinology. 1999; 140: 1861 -1868.[Abstract /Liber Full Text]
Traish AM, Toselli P: Jeong SI, Kim Nullum adhibeat NN. Adipocito cumulus in corpus cavernosum de penis orchiectomized lepus: a mechanism enim potentiale, veno occlusive androgen distemperantia in diminutione consistens. J Androl. 2005: 26: 242 -248.[Abstract /Liber Full Text]
Udelson D, A Nehra, Hatzichristou D, K Azadzoi, Moreland RB, Marcus Tullius Krane, Saenz de Tejada Ego arcum ecliptice EN I. Analysis Engineering de penis et structuralem hemodynamic dynamic relationes, pars III-orci studiis rationis et rigiditatis penis hemodynamic erectile respondeo. Int J impot Res. 1998: 10: 89 -99.[CrossRef][Medline]
Cicero, erunt GF, Ruminant KK, Stuckey BG. Praesent in-endothelial erectile nexu: occasiones pro novus cardiovascular periculo ne. Clin Pract med natura Cardiovasc. 2007; 4: 263 -273.[CrossRef][Medline]
E Wespes Blasphema caterva PM Schiffmann S, M Deprierreux, JJ Vanderhaeghen, Schulman CC. Computerised lenis musculus fibris in analysis de aegris potentes et impotentes. J Urol. 1991; 146: 1015 -1017.[Medline]
Wespes E, G Raviv, Vanegas JP, Decaestecker C, M Petein, Danguy A, C Schulman, R. Corporeal Apprehendite disciplinam, veno occlusive distemperantia, sit superne arteriarum morbis? J Urol. 1998; 160: 2054 -2057.[CrossRef][Medline]
Wespes E, A Rammal, Garbar C. responders, non Sildenafil: et haemodynamic morphometric studiis. Eur Urol. 2005; 48: 136 -139.[CrossRef][Medline]
E Wespes, Sattar Rom Golzarian J, Wery D, N mi dicit, Schulman CC. Praesent Corporeal veno, occlusive: intracavernous musculorum magis atque pathologia. J Urol. 1997; 157: 1678 -1680.[CrossRef][Medline]
E Wespes, Schiffmann S, M Depierreux, JJ Vanderhaegan, Schulman CC. Huiusmodi reductio ad cavernovenous est lacus intracavernous lenis musculus fibris? Int J impot Res. 1990; 2: 30.
Yassin A, F Saad, Traish erectile munus in montem Domini undecanoate Testosterone A. restant adhuc de aegris cum venarum ultrices: seriem causam refert. Sex med J. 2006; 3: 727 -735.[CrossRef][Medline]