Kodi kuseweretsa maliseche kwambiri kunachepetsa ma testosterone anga?

Yankho: Kulephera kwa umboni kumanena kuti izi sizingatheke.

Werengani nkhaniyi kuti mudziwe zambiri zokhudza zotsatira za umuna: Amuna: Kodi Kutulutsa umuna pafupipafupi kumayambitsa matenda a hangover?

Nzosadabwitsa kuti anthu ambiri ogwiritsa ntchito zolaula omwe ali ndi vuto la erectile dysfunction amaganiza kuti maliseche achepetsa kuchuluka kwa testosterone m'magazi awo. Amuna omwe amalemba pama forum nthawi zambiri amanena kuti, " Mayeso anga onse a labu adabweranso bwino, kuphatikiza kuchuluka kwa T, kotero dokotala adandipatsa Viagra ."

Choyamba, n’zosowa kwambiri kuti ED mwa anyamata ichitike chifukwa cha testosterone yochepa. Chachiwiri, amuna omwe ali ndi ED yoyambitsidwa ndi zolaula nthawi zonse amanena kuti testosterone imakhala yofanana, koma nthawi zambiri amatuluka umuna. Kuphatikiza apo, maphunziro amanenanso kuti testosterone imakhala yofanana mwa amuna athanzi komanso amuna omwe ali ndi ED yosatha ( 1, 2, 3, 4 ). Kuchokera pa izi, maphunziro ambiri omwe afotokozedwa pansipa, komanso umboni wosadziwika, tinganene kuti:

  • testosterone sichimawathandiza kukhala achinyamata a ED
  • Kuthamanga kwafupipafupi sikumene kumakhudza magulu a testosterone.

Mwachidule, sitikudziwa umboni uliwonse wofufuza (pakadali pano) womwe umasonyeza kuti testosterone yotsika imakhudza zotsatira zoyipa zomwe zanenedwa za kugwiritsa ntchito zolaula/kuseweretsa maliseche. Ndipotu, umboni nthawi zambiri umasonyeza kuti ubongo umayendetsa bwino mphoto ndi hypothalamus ngati zinthu zofunika kwambiri pa zizindikiro zokhudzana ndi zolaula, komanso kusowa kwa kugonana komwe kumayambitsa zolaula. Onani vidiyoyi kuti mudziwe zambiri.

Izi sizitanthauza kuti kusintha kwina kwamaubongo okhudza zolaula sikungasinthe mahomoni oyenda. Ndizotheka kuti amatero, chifukwa zosokoneza bongo zimasintha madera oyendetsera mphotho, omwe angakhudze machitidwe owongolera mahomoni. Mkhalidwe wapano wa sayansi:

  1. Testosterone "sichigwiritsidwa ntchito" potulutsa kapena kuseweretsa maliseche, ngakhale testosterone receptors ikhoza kuchepetsedwa kwa masiku 3-4 pambuyo pa kutsegulidwa.
  2. Zofufuza pa zonsezi kudziletsa ndipo "Kuthamangitsidwa ku kutopa kwa kugonana”Onetsani kuti alibe mphamvu pamlingo wa testosterone.
  3. Ndipotu, olemba a phunziroli ndi phunziroli amasonyeza kuti kudziletsa kungachititse kuti ma testosterone asachepetse.
  4. Palibe kusiyana pakati pa kugonana, kapena kudziletsa, ndi testosterone ya plasma - zina osati tsiku limodzi lamasiku osachepera (46% pamwambapa) patatha masiku asanu ndi awiri kudziletsa. Pambuyo pa tsiku limodzi lokha testosterone idabwerera koyambira mpaka kumapeto kwa kuyeserera tsiku la 16.
  5. Komabe, pali umboni woti kukodzedwa mpaka kufika pa kugonana zimayambitsa kusintha kwamaubongo angapo - kuphatikiza a kuchepa ndi atrogen receptors ndi kuwonjezeka kwa obvomerezeka a estrogen m'madera angapo a ubongo. Kubwezeretsedwa kwa chilakolako chogonana chokwanira kumatenga masiku a 7-15 ndipo sizingatheke kusintha kwa ubongo.
  6. Zithunzi zolaula zomwe zimapangitsa ED sizikugwirizana ndi kuchuluka kwama testosterone. Umboni wosadziwika, maphunziro osawerengeka a ED, ndi ma erectile physiology onse amatsutsa izi. Onani zokambirana izi ndi pulofesa wokhudzana ndi kubereka - Hypogonadal amuna ndi zosankhidwa
  7. Palibe kusiyana pakati pa kugonana, kapena kudziletsa, ndi testosterone ya plasma - zina osati tsiku limodzi lamasiku osachepera (46% pamwambapa) patatha masiku asanu ndi awiri kudziletsa. Lonse kusinthasintha kwa milingo ya testosterone yamphongo (10-40%) ndi zachilendo.
  8. Palibe umboni wodziletsa wosakweza ma testosterone. Kafukufuku awiri okha ndi omwe adayesa kuchuluka kwa T pakutha kwa nthawi yayitali - ndipo onse awiri sanapeze kusintha:
    1.  "Wotchuka" Kuphunzira China miyeso ya T tsiku lililonse kwa masiku 16, ndipo adapeza kuwonjezeka pang'ono mpaka tsiku la 6 - ndikubwerera pazoyambira (pang'ono pansipa) kuyambira tsiku la 8 mpaka tsiku la 16 pomwe kuyesa kudatha.
    2. Phunziro mu #4
  9. izi umboni - Kuchitapo kanthu kwa khunyu kumatenda opatsirana pogonana chifukwa cha maliseche omwe amachititsa kuti abambo azikhala osagonana, kumene maphunziro sanatenge umuna kwa masabata a 3, amatchulidwa kawirikawiri ngati umboni wakuti kudziletsa kumabweretsa testosterone yowonjezera. Sizitero. Chiganizo ichi sichinalembedwe bwino komanso chimasocheretsa: "ngakhale kuti testosterone ya plasma inali yosasinthika ndi zovuta, ma testosterone apamwamba ankawonekera pambuyo pa nthawi ya kudziletsa“. Mu fayilo ya kuphunzira kwathunthu, mayeso a testosterone ali ofanana m'magulu awiriwa. Fufuzani grayi ya testosterone C on tsamba 379. Zindikirani kuchuluka kwa testosterone koyambirira kwa kanemayo (miniti ya 10) inali yofanana m'magulu onse awiriwa. Mapeto a nkhani. Chilankhulo chosokoneza mumabukuwa chimatanthawuza za kusiyana kwa testosterone mukamasewera. Pomwe mukuwonera kanema wokonda zolaula komanso maliseche, ma T-level adatsika chifukwa chodziletsa kale. Pambuyo masiku 21 odziletsa, ma T-level adakhala pafupi kwambiri ndi gawo loyambira la 10 pakuseweretsa maliseche. Mawuwo - "kuchuluka kwa testosterone kunalikuchitika pambuyo pa nthawi ya kudziletsa"- zikutanthauza kuti kuchuluka kwa testosterone sikunagwe kwambiri panthawi yolimbikitsayo: maliseche & kuwonera zolaula. Olembawo akuti kuyembekezera kuonera zolaula (mwina zowonjezeredwa ndi chiyembekezo chotsiriza maliseche) zidapangitsa testosterone kukhalabe yokwera nthawi yonse yowonera.
  10. Maphunziro apamwamba Nthawi zonse mumapeza kuti kutulutsa "kutopa kwazakugonana" sikukhudza magulu a testosterone. Maphunzirowa amatsata nyamazo mpaka masiku 15. Komabe, amapeza zosintha zingapo mkati mwa limbic system, kuphatikiza kuchepa kwa ma androgen receptors, ndikuwonjezeka kwama estrogen receptors & opioids (omwe amaletsa dopamine), ndikusintha kwamatenda amtundu.
  11. Zakale maphunziro pa anyamata sanasonyeze mgwirizano wodalirika pakati pa ejaculation ndi testosterone magazi.
  12. Mwa njira, ma level testosterone kawirikawiri amasinthasintha kuchokera ku 10-40%.
  13. izi phunziro limodzi kuchokera ku 1974 adanenanso zochepa zogonana zomwe zikugwirizana ndi testosterone wapamwamba - pamitu ina, koma osati yonse. Komabe, kafukufukuyu adapezanso kuti kuchuluka kwamtundu wa testosterone kumalumikizidwa ndi nthawi yogonana. Zotsutsana pang'ono. Tiyeni tiike phunziroli motere: Silinatchulidwepo konse ndipo lili ndi mitundu yambiri yosalamulirika. Zofufuza zina zonse za nyama ndi anthu zomwe zimawunika testosterone komanso kuchuluka kwanthawi yayitali, kudziletsa, magawo osiyanasiyana azogonana, komanso kukanika kwa erectile kumatsutsa zomwe zapezedwa.

Maubwenzi odalirika komanso machitidwe ogwirizana , monga kugonana, kumawonjezera thanzi labwino, kotero kudzipatula kapena njira zina zogwiritsira ntchito zolaula kwambiri zitha kuletsa mwachindunji kuchuluka kwa testosterone, kudzera mu epigenetics kapena zinthu zina zomwe zimasintha magwiridwe antchito a maselo.

Nayi gawo la zokambirana zokhudza kuchuluka kwa testosterone ndi ma anabolic steroids zomwe zingakhale zosangalatsa kwa alendo omanga thupi. Dziwani: Wogwiritsa ntchito ma steroid akhoza kukhala wokonda ma steroid. Ngakhale kuyesera pang'ono ndi makoswe, omwe sasamala za momwe amaonekera, kumasonyeza kuti amakonda ma anabolic steroids. Chifukwa chake sikuti kungofuna kusunga minofu yomwe yakula komwe kumakopa ogwiritsa ntchito. Kuchuluka kwa testosterone kumalepheretsanso kupanga testosterone yanu. Samalani.

  • funso: Kodi mwakhala pa HRT nthawi yayitali bwanji? Pali mabuku omwe akukula omwe akuwonetsa kuti testosterone yotsika imabweretsa kusintha kwamapangidwe a minofu ya erectile, zomwe zimapangitsa kuti erectile iwonongeke. Ngati testosterone yanu idatsimikizika kuti ndiyotsika, izi mwina ndizomwe zimayambitsa mavuto anu apano. Mwamwayi, zawonetsedwa kuti kusintha kumeneku m'matumbo a erectile kumasinthidwa ndi HRT. Zingakhale zomveka kuyembekezera kuti zingatenge nthawi yayitali kuti ma erections anu asinthe kuposa momwe zingatengere kuti testosterone yanu ifike pamagulu abwinobwino, popeza ndiko kusintha kwenikweni kwa minofu yosalala, osati nkhani yosavuta yamahomoni amwazi. Chifukwa chofuna kudziwa, ndingafunse msinkhu wanu, mwakhala mukukumana ndi mavuto a erectile kwa nthawi yayitali bwanji, ndipo mwalandira chithandizo chotalika bwanji mpaka pano?
  • Yankho: Ndili pa HRT tsopano kwa zaka 2. Ndili ndi zaka 40 tsopano. Ndakhala katswiri wothamanga mwamphamvu kwa zaka 20. Munthawi imeneyi ndimakonda kugwiritsa ntchito anabolic steroids (AAS). Ichi ndiye chifukwa chake testosterone yanga idatsika nditasiya kugwiritsa ntchito AAS zaka 3 zapitazo. Pambuyo pa chaka chimodzi ndikuchira ma testosterone anga amkati sanalipo, ndipamene ndidapita ku HRT. Zaka zapitazi za 8, mtundu wazomwe ndidasankha zakhala zoyipa. Chifukwa chake, ndipamene ndimakhala ndikutuluka ndi AAS komanso panthawi ya HRT. Pali zinthu zambiri zomwe zakhudzidwa kotero kuti ndizovuta kunena zomwe zikuyambitsa ED yanga. Ndinkayembekeza kuti kuyambiranso kungandithandizire pavutoli. Pakadali pano sindikudziwa zina zomwe ndingasankhe.

Kusagwirizana ndi kugonana kumawombera kuchepetsa kutembenuka kwa LH bioavailability.

Int J Impot Res. 2002 Apr;14(2):93-9; kukambirana 100.

Carosa E , Benvenga S , Trimarchi F , Lenzi A , Pepe M , Simonelli C , Jannini EA.

Kudalirika

Posachedwapa talemba za kuchepa kwakukulu kwa testosterone (T) m'magazi mwa odwala omwe ali ndi vuto la erectile dysfunction (ED). Kuti timvetse momwe hypotestosteronemia imagwirira ntchito, yomwe sinali yosiyana ndi chifukwa cha ED, komanso momwe imasinthira kokha mwa odwala omwe njira zosiyanasiyana zochiritsira zosagwiritsa ntchito mahomoni zinabwezeretsa kugonana, tinayesa hormone ya luteinizing m'magazi (LH) m'gulu lomwelo la odwala ED (n=83; 70% organic, 30% nonorganic). Onse awiri, LH yogwira ntchito m'thupi (I-LH) ndi LH yogwira ntchito m'thupi (B-LH) adayesedwa poyambira ndi miyezi itatu pambuyo pa chithandizo. Kutengera zotsatira (monga chiwerengero cha kuyesa bwino kugonana pamwezi), odwala adagawidwa m'magulu ngati oyankha mokwanira (monga, mayeso osachepera asanu ndi atatu; n=51), oyankha pang'ono (osachepera kamodzi; n=20) ndi osayankha (n=16). Poyerekeza ndi amuna 30 athanzi omwe alibe ED, B-LH yoyambira (pakati +/-sd) mwa odwala 83 idachepa (13.6 +/-5.5 vs 31.7 +/-6.9 IU/L, P<0.001), chifukwa cha kuwonjezeka pang'ono, koma m'malo abwinobwino, I-LH (5.3 +/-1.8 vs 3.4 +/-0.9 IU/L, P<0.001); chifukwa chake, chiŵerengero cha B/I LH chidachepa (3.6 +/-3.9 vs 9.7 +/-3.3, P<0.001). Mofanana ndi zomwe tidawona kale za serum T, magulu atatu a zotsatira sanasiyane kwambiri pa chilichonse mwa magawo atatuwa poyambira. Komabe, magulu a zotsatira adasiyana pambuyo pa chithandizo. Kugwira ntchito kwa LH m'thupi kunawonjezeka kwambiri mwa anthu omwe anayankha mokwanira (pre-therapy=13.7+/-5.3, post-therapy=22.6+/-5.4, P<0.001), pang'ono mwa anthu omwe anayankha pang'ono (14.8+/-6.9 vs 17.2+/-7.0, P<0.05) koma sikunasinthe mwa anthu omwe sanayankhe (11.2+/-2.2 vs 12.2+/-5.1). Kusintha kofananako kunapita mbali yosiyana ya I-LH (5.2+/-1.7 vs 2.6+/-5.4, P<0.001; 5.4+/-2.2 vs 4.0+/-1.7, P<0.05; 5.6+/-1.2 vs 5.0+/-1.2, motsatana), ndipo mbali imodzi ndi B-LH ya chiŵerengero cha B/I (3.7+/-4.1 vs 11.8+/-7.8, P<0.001; 4.2+/-4.3 vs 5.8+/-4.2, P<0.05; 2.1+/-0.7 vs 2.6+/-1.3, motsatana). Tikuganiza kuti hypotestosteronemia ya odwala ED imachitika chifukwa cha kuchepa kwa bioactivity ya LH. Kuchepa kwa bioactivity kumeneku kumatha kusinthidwa, bola ngati kuyambiranso kuchita zogonana kukuchitika mosasamala kanthu za njira yochiritsira. Popeza mphamvu ya mahomoni a pituitary imayendetsedwa ndi hypothalamus, kuchepa kwa ntchito ya LH kuyenera kukhala chifukwa cha kuwonongeka kwa ntchito ya hypothalamic komwe kumakhudzana ndi kusokonezeka kwa maganizo komwe kumachitika chifukwa cha kusachita zinthu zogonana.

MAFUNSO: Olemba amati kupititsa patsogolo kugonana kumawonjezera LH ndi testosterone mwa amuna omwe amatsata ED. Palibe mmodzi wa amuna abwino omwe anachitidwa ndi mahomoni, ndipo otsika testosterone sanali chifukwa cha ED. Ngati ndi zoona kwa amuna abwino, izi zikusonyeza kuti kugonana / kuthamanga kungalepheretse kuchepa kwa magulu a testoterone.

ZOCHITIKA PAKATI PA MAFUNSO NDI MAFULU A NKHANI ZOKHUDZA KWAMBIRI KUCHITA MALAMULO

Scand J Psychol. 2003 Jul;44(3):257-63.

Fernández-Guasti A, Rodríguez-Manzo G.

Kudalirika

Nkhani yamakono ikufotokoza zomwe zapeza tsopano pa zochitika zosangalatsa za kugonana. Knut Larsson mu 1956 adafotokoza za kukula kwa kugonana kwa amuna amphongo pambuyo pobwereza. Taphunzira njirayi ndikupeza zotsatira zotsatirazi.

(1) Tsiku lina pambuyo pa maola a 4 a malingaliro a libitum, awiri mwa magawo atatu a anthu adasonyeza kuletsa kwathunthu khalidwe la kugonana, pamene gawo lina lachitatu likuwonetsa mndandanda umodzi wosasintha.

(2) Mankhwala amachiritso amodzi, kuphatikizapo 8-OH-DPAT, yohimbine, naloxone ndi naltrexone, amatsutsana ndi kugonana kumeneku, kusonyeza kuti njira za noradrenergic, serotonergic ndi opiate zikugwira ntchitoyi. Zoonadi, kulumikizana kwa matenda a ubongo kumasonyeza kusintha kwa matenda osiyanasiyana pa nthawi ya kugonana.

(3) Popeza kuti chilakolako cha kugonana chinali chokwanira, kusintha chilakolako cha kugonana kunaletsa chilakolako cha kugonana, zomwe zikusonyeza kuti pali zinthu zina zomwe zimapangitsa kuti chilakolako cha kugonana chikhale chofooka.

(4) GABA yemwe amatsutsana ndi bicuculline, kapena kukakamizidwa kwa magetsi kwa malo apakati, sanagwirizanitse kugonja kwa kugonana. Deta izi zimasonyeza kuti kugona kwa kugonana ndi nthawi ya postejaculatory (yomwe yafupikitsidwa ndi bicuculline administration) sichiyanjanitsidwa ndi njira zofananamo, ndipo zina, kuti malo amodzi omwe sagwirizane nawo sagwirizanitsa kugonana.

(5) Kuchuluka kwa ma androgen receptor m'malo a ubongo omwe amagwirizana kwambiri ndi kuwonetsa kwa khalidwe la amuna pogonana, monga medial preoptic nucleus, kunachepa kwambiri mwa nyama zomwe zinatopa pogonana. Kuchepa koteroko kunali kwapadera m'malo ena a ubongo ndipo sikunali kogwirizana ndi kusintha kwa milingo ya ma androgens. Zotsatirazi zikusonyeza kuti kusintha kwa ma androgen receptors mu ubongo kumayambitsa kuletsa khalidwe la kugonana lomwe limakhalapo panthawi yogonana.

(6) Kuchira kwa kukhuta pambuyo pa maola 4 a kugonana kwa ad libitum kukuwonetsa kuti, patatha masiku 4, 63% yokha ya amuna ndi omwe amatha kusonyeza khalidwe la kugonana pomwe patatha masiku 7 nyama zonse zimachita zogonana.

MAFUNSO: Mbali ya ubongo komwe kuchepa kwa phwando kumakhala kofanana kwambiri ndi zinyama zonse. Ngati kugwa kwa testosterone amalandila amapezeka mwa amuna, zikhoza kufotokoza chifukwa chake amuna ena amamverera ngati testosterone yawo ili yochepa pakapita nthawi, ndipo chifukwa chake amamverera ngati testosterone yawo imakhala ndi nthawi yodziletsa.

ZOYENERA: Kusintha kwa kanthawi kochepa kumeneku kumayesedwa mu ubongo wamba. Ngati ubongo wanu wasintha chifukwa cha kuledzeretsa, dopamine yanu imayambanso kusokonekera, mwinamwake osati kuchepa kwa testosterone receptors, ndipo mudzafunika nthawi yaitali kuti mubwererenso ku libido.

Komanso: # 4 - Kutopa ndi kugonana kunalephereka poyambitsa mkazi wachikazi (ndizomwe zolaula zimachita).

Kuwonjezeka kwa estrogen receptor alpha immunoreactivity mu makina a makoswe opatsirana pogonana.

Horm Behav. 2007 Marichi 51(3):328-34. Epub 2007 Jan 19.

Phillips-Farfán BV , Lemus AE , Fernández-Guasti A.

Kudalirika

Estrogen receptor alpha (ERalpha) imagwira ntchito yoletsa machitidwe a kugonana kwa amuna, makamaka m'malo a ubongo omwe ali mu limbic system. Amuna amitundu yambiri amakhala ndi vuto la nthawi yayitali la khalidwe logonana pambuyo potulutsa umuna kangapo, komwe kumadziwika kuti kukhuta. Zawonetsedwa kuti kuchuluka kwa androgen receptor kumachepa maola 24 pambuyo potulutsa umuna kamodzi kapena kukhuta , m'dera la medial preoptic, nucleus accumbens ndi ventromedial hypothalamus. Cholinga cha kafukufukuyu chinali kufufuza ngati kuchuluka kwa ERalpha kunasinthidwanso maola 24 pambuyo potulutsa umuna kamodzi kapena kukhuta. Kukhuta kugonana kunagwirizanitsidwa ndi kuchuluka kwa ERalpha mu anteromedial bed nucleus ya stria terminalis (BSTMA), ventrolateral septum (LSV), posterodorsal medial amygdala (MePD), medial preoptic area (MPA) ndi nucleus accumbens core (NAc). Kutulutsa umuna kamodzi kunali kogwirizana ndi kuwonjezeka kwa kuchuluka kwa ERalpha mu BSTMA ndi MePD. Kuchuluka kwa ERalpha mu arcuate (Arc) ndi ventromedial hypothalamic nuclei (VMN), ndi kuchuluka kwa estradiol m'magazi sikunasinthe maola 24 pambuyo pa kutulutsa umuna kapena kugonana mpaka kukhuta. Deta iyi ikusonyeza ubale pakati pa zochita zogonana ndi kuwonjezeka kwa ERalpha m'malo enaake a ubongo, mosasamala kanthu za kuchuluka kwa estradiol m'magazi.

MAFUNSO: Estrogen receptors density imawonjezeka m'madera angapo pokhapokha kutayika, komanso kugonana. Mu phunziro lathunthu iwo amati kusintha uku kumatenga nthawi yayitali kuposa 24 hrs.