Kodi kuseweretsa maliseche kwambiri kunachepetsa ma testosterone anga?

Yankho: Kulephera kwa umboni kumanena kuti izi sizingatheke.

Werengani nkhaniyi mwachidule pa zotsatira za kutsegula: Amuna: Kodi Kuthamangitsidwa Kwafupipafupi Chifukwa Chakudya?

Ndizosadabwitsa kuti ogwiritsa ntchito zolaula ambiri omwe amakhala ndi vuto la erectile akukayikira kuti kuseweretsa maliseche kwachepetsa ma testosterone awo. Amuna omwe amalemba pamabwalo nthawi zambiri amalankhula zonga izi, "Mayesero anga onse amabwereranso mwachibadwa, kuphatikizapo ma T, kotero adokotala anandipatsa Viagra. "

Choyamba, ndizosowa kwambiri kwa ED mwa anyamata chifukwa cha testosterone. Chachiwiri, amuna omwe amapangitsa zolaula za ED nthawi zonse amafotokoza ma testosterone abwinobwino, komabe achita nawo zambiri. Kuphatikiza apo, kafukufuku amafotokoza ma testosterone ofanana mwa amuna ndi abambo athanzi osatha ED (1, 2, 3, 4). Kuchokera pa izi, maphunziro ambiri omwe takambiranawa m'munsimu, ndi umboni wovomerezeka, tingathe kunena kuti:

  • testosterone sichimawathandiza kukhala achinyamata a ED
  • Kuthamanga kwafupipafupi sikumene kumakhudza magulu a testosterone.

Mwachidule, sitikudziwa umboni uliwonse (komabe) womwe umapangitsa testosterone kutsika pazotsatira zoyipa zakugwiritsa ntchito zolaula / maliseche. Pamenepo, umboni Nthawi zambiri zimalozera kumalipiro aubongo ozungulira ndi hypothalamus monga ochita pakati pazizindikiro zokhudzana ndi zolaula, komanso zolaula zomwe zimapangitsa kuti munthu azichita zachiwerewere. Mwawona kanema iyi mwatsatanetsatane.

Izi sizitanthauza kuti kusintha kwina kwamaubongo okhudza zolaula sikungasinthe mahomoni oyenda. Ndizotheka kuti amatero, chifukwa zosokoneza bongo zimasintha madera oyendetsera mphotho, omwe angakhudze machitidwe owongolera mahomoni. Mkhalidwe wapano wa sayansi:

  1. Testosterone "sichigwiritsidwa ntchito" potulutsa kapena kuseweretsa maliseche, ngakhale testosterone receptors ikhoza kuchepetsedwa kwa masiku 3-4 pambuyo pa kutsegulidwa.
  2. Zofufuza pa zonsezi kudziletsa ndipo "Kuthamangitsidwa ku kutopa kwa kugonana”Onetsani kuti alibe mphamvu pamlingo wa testosterone.
  3. Ndipotu, olemba a phunziroli ndi phunziroli amasonyeza kuti kudziletsa kungachititse kuti ma testosterone asachepetse.
  4. Palibe kusiyana pakati pa kugonana, kapena kudziletsa, ndi testosterone ya plasma - zina osati tsiku limodzi lamasiku osachepera (46% pamwambapa) patatha masiku asanu ndi awiri kudziletsa. Pambuyo pa tsiku limodzi lokha testosterone idabwerera koyambira mpaka kumapeto kwa kuyeserera tsiku la 16.
  5. Komabe, pali umboni woti kukodzedwa mpaka kufika pa kugonana zimayambitsa kusintha kwamaubongo angapo - kuphatikiza a kuchepa ndi atrogen receptors ndi kuwonjezeka kwa obvomerezeka a estrogen m'madera angapo a ubongo. Kubwezeretsedwa kwa chilakolako chogonana chokwanira kumatenga masiku a 7-15 ndipo sizingatheke kusintha kwa ubongo.
  6. Zithunzi zolaula zomwe zimapangitsa ED sizikugwirizana ndi kuchuluka kwama testosterone. Umboni wosadziwika, maphunziro osawerengeka a ED, ndi ma erectile physiology onse amatsutsa izi. Onani zokambirana izi ndi pulofesa wokhudzana ndi kubereka - Hypogonadal amuna ndi zosankhidwa
  7. Palibe kusiyana pakati pa kugonana, kapena kudziletsa, ndi testosterone ya plasma - zina osati tsiku limodzi lamasiku osachepera (46% pamwambapa) patatha masiku asanu ndi awiri kudziletsa. Lonse kusinthasintha kwa milingo ya testosterone yamphongo (10-40%) ndi zachilendo.
  8. Palibe umboni wodziletsa wosakweza ma testosterone. Kafukufuku awiri okha ndi omwe adayesa kuchuluka kwa T pakutha kwa nthawi yayitali - ndipo onse awiri sanapeze kusintha:
    1.  "Wotchuka" Kuphunzira China miyeso ya T tsiku lililonse kwa masiku 16, ndipo adapeza kuwonjezeka pang'ono mpaka tsiku la 6 - ndikubwerera pazoyambira (pang'ono pansipa) kuyambira tsiku la 8 mpaka tsiku la 16 pomwe kuyesa kudatha.
    2. Phunziro mu #4
  9. izi umboni - Kuchitapo kanthu kwa khunyu kumatenda opatsirana pogonana chifukwa cha maliseche omwe amachititsa kuti abambo azikhala osagonana, kumene maphunziro sanatenge umuna kwa masabata a 3, amatchulidwa kawirikawiri ngati umboni wakuti kudziletsa kumabweretsa testosterone yowonjezera. Sizitero. Chiganizo ichi sichinalembedwe bwino komanso chimasocheretsa: "ngakhale kuti testosterone ya plasma inali yosasinthika ndi zovuta, ma testosterone apamwamba ankawonekera pambuyo pa nthawi ya kudziletsa“. Mu fayilo ya kuphunzira kwathunthu, mayeso a testosterone ali ofanana m'magulu awiriwa. Fufuzani grayi ya testosterone C on tsamba 379. Zindikirani kuchuluka kwa testosterone koyambirira kwa kanemayo (miniti ya 10) inali yofanana m'magulu onse awiriwa. Mapeto a nkhani. Chilankhulo chosokoneza mumabukuwa chimatanthawuza za kusiyana kwa testosterone mukamasewera. Pomwe mukuwonera kanema wokonda zolaula komanso maliseche, ma T-level adatsika chifukwa chodziletsa kale. Pambuyo masiku 21 odziletsa, ma T-level adakhala pafupi kwambiri ndi gawo loyambira la 10 pakuseweretsa maliseche. Mawuwo - "kuchuluka kwa testosterone kunalikuchitika pambuyo pa nthawi ya kudziletsa"- zikutanthauza kuti kuchuluka kwa testosterone sikunagwe kwambiri panthawi yolimbikitsayo: maliseche & kuwonera zolaula. Olembawo akuti kuyembekezera kuonera zolaula (mwina zowonjezeredwa ndi chiyembekezo chotsiriza maliseche) zidapangitsa testosterone kukhalabe yokwera nthawi yonse yowonera.
  10. Maphunziro apamwamba Nthawi zonse mumapeza kuti kutulutsa "kutopa kwazakugonana" sikukhudza magulu a testosterone. Maphunzirowa amatsata nyamazo mpaka masiku 15. Komabe, amapeza zosintha zingapo mkati mwa limbic system, kuphatikiza kuchepa kwa ma androgen receptors, ndikuwonjezeka kwama estrogen receptors & opioids (omwe amaletsa dopamine), ndikusintha kwamatenda amtundu.
  11. Zakale maphunziro pa anyamata sanasonyeze mgwirizano wodalirika pakati pa ejaculation ndi testosterone magazi.
  12. Mwa njira, ma level testosterone kawirikawiri amasinthasintha kuchokera ku 10-40%.
  13. izi phunziro limodzi kuchokera ku 1974 adanenanso zochepa zogonana zomwe zikugwirizana ndi testosterone wapamwamba - pamitu ina, koma osati yonse. Komabe, kafukufukuyu adapezanso kuti kuchuluka kwamtundu wa testosterone kumalumikizidwa ndi nthawi yogonana. Zotsutsana pang'ono. Tiyeni tiike phunziroli motere: Silinatchulidwepo konse ndipo lili ndi mitundu yambiri yosalamulirika. Zofufuza zina zonse za nyama ndi anthu zomwe zimawunika testosterone komanso kuchuluka kwanthawi yayitali, kudziletsa, magawo osiyanasiyana azogonana, komanso kukanika kwa erectile kumatsutsa zomwe zapezedwa.

Ubale, wodalirika komanso makhalidwe abwino, monga kugonana kokha, kuwonjezera ubwino wadziko lonse, kudzipatula kapena zina zochitika za moyo za kugwiritsira ntchito zolaula zolemetsa zingathe kusokoneza mavoti a testosterone, pogwiritsa ntchito epigenetics kapena zinthu zina zomwe zimasintha maselo.

Nayi gawo losinthana pamiyeso ya testosterone ndi anabolic steroids zomwe zitha kukhala zosangalatsa kwa alendo olimbitsa thupi. Chidziwitso: Wogwiritsa ntchito steroid amatha kumwerekera ndi ma steroids. Ngakhale kuyeserera kochepa chabe ndi makoswe, komwe sikusamala momwe amawonekera, kumawonetsa kukondera kwa anabolic steroids. Chifukwa chake sikofunikira kokha kwamaganizidwe kuti minofu ikhale yolumikizira ogwiritsa ntchito. Mlingo wapamwamba komanso ziletsa testosterone yanu yopanga. Samalani.

  • funso: Kodi mwakhala pa HRT nthawi yayitali bwanji? Pali mabuku omwe akukula omwe akuwonetsa kuti testosterone yotsika imabweretsa kusintha kwamapangidwe a minofu ya erectile, zomwe zimapangitsa kuti erectile iwonongeke. Ngati testosterone yanu idatsimikizika kuti ndiyotsika, izi mwina ndizomwe zimayambitsa mavuto anu apano. Mwamwayi, zawonetsedwa kuti kusintha kumeneku m'matumbo a erectile kumasinthidwa ndi HRT. Zingakhale zomveka kuyembekezera kuti zingatenge nthawi yayitali kuti ma erections anu asinthe kuposa momwe zingatengere kuti testosterone yanu ifike pamagulu abwinobwino, popeza ndiko kusintha kwenikweni kwa minofu yosalala, osati nkhani yosavuta yamahomoni amwazi. Chifukwa chofuna kudziwa, ndingafunse msinkhu wanu, mwakhala mukukumana ndi mavuto a erectile kwa nthawi yayitali bwanji, ndipo mwalandira chithandizo chotalika bwanji mpaka pano?
  • Yankho: Ndili pa HRT tsopano kwa zaka 2. Ndili ndi zaka 40 tsopano. Ndakhala katswiri wothamanga mwamphamvu kwa zaka 20. Munthawi imeneyi ndimakonda kugwiritsa ntchito anabolic steroids (AAS). Ichi ndiye chifukwa chake testosterone yanga idatsika nditasiya kugwiritsa ntchito AAS zaka 3 zapitazo. Pambuyo pa chaka chimodzi ndikuchira ma testosterone anga amkati sanalipo, ndipamene ndidapita ku HRT. Zaka zapitazi za 8, mtundu wazomwe ndidasankha zakhala zoyipa. Chifukwa chake, ndipamene ndimakhala ndikutuluka ndi AAS komanso panthawi ya HRT. Pali zinthu zambiri zomwe zakhudzidwa kotero kuti ndizovuta kunena zomwe zikuyambitsa ED yanga. Ndinkayembekeza kuti kuyambiranso kungandithandizire pavutoli. Pakadali pano sindikudziwa zina zomwe ndingasankhe.

Kusagwirizana ndi kugonana kumawombera kuchepetsa kutembenuka kwa LH bioavailability.

Int J Impot Res. 2002 Apr; 14 (2): 93-9; kukambirana 100.

Carosa E, Benvenga S, Trimarchi F, Lenzi A, Pepe M, Simonelli C, Jannini EA.

Kudalirika

Posachedwapa talemba zochepa kwambiri za maselo a tesumsterone (T) odwala omwe ali ndi erectile dysfunction (ED). Kuti timvetse njira ya hypisttosteronemia imeneyi, yomwe idali yopanda mphamvu ya ED e, komanso yowonjezera kwa odwala omwe amachiritsira mankhwala osakanizidwa osiyanasiyana, tinayesa ma hormone luteinizing (LH) mu gulu limodzi la odwala ED. n = 83; 70% organic, 30% yosagwirizana). Zomwe ma immunoreactive LH (I-LH) ndi bioactive LH (B-LH) amayesedwa pa kulowa ndi miyezi 3 mutatha mankhwala. Malingana ndi zotsatira (mwachitsanzo, chiwerengero cha kuyesayesa bwino kwa kugonana pamwezi), odwala amagawidwa ngati omvera onse (kutanthauza mayesero osachepera asanu ndi atatu; n = 51), oyankhapo pang'ono (osayesa pang'ono; n = 20) ndi osayankha (n = 16). Poyerekeza ndi amuna a 30 athanzi opanda ED, mzere woyambira B-LH (kutanthauza +/- sd) mwa odwala 83 adatsika (13.6 +/- 5.5 vs 31.7 +/- 6.9 IU / L, P <0.001), pamaso pa kuchuluka pang'ono, koma mwachizolowezi, I-LH (5.3 +/- 1.8 vs 3.4 +/- 0.9 IU / L, P <0.001); chifukwa chake, kuchuluka kwa B / I LH kunachepetsedwa (3.6 +/- 3.9 vs 9.7 +/- 3.3, P <0.001). Mofananamo ndi zomwe tinaziwona kale pa seramu T, magulu atatu otulukapo sanawoneke mosiyana kwambiri ndi iliyonse ya magawo atatuwa pazotsatira. Komabe, magulu otsogolera amasiyana ndi mankhwalawa. Kusakondera kwa LH kunakula kwambiri mwa omvera onse (pre-therapy=13.7+/-5.3, post-therapy=22.6+/-5.4, P<0.001), Odzichepetsa amatsankho (14.8 +/- 6.9 vs 17.2 +/- 7.0, P <0.05) koma osasinthika mwa osayankha (11.2 +/- 2.2 vs 12.2 +/- 5.1). Kusintha kofananako kunapita mbali ina ya I-LH (5.2 +/- 1.7 vs 2.6 +/- 5.4, P <0.001; 5.4 +/- 2.2 vs 4.0 +/- 1.7, P <0.05; 5.6 +/- 1.2 vs 5.0 +/- 1.2, motsatana), komanso mbali yomweyo monga B-LH ya chiŵerengero cha B / I (3.7 +/- 4.1 vs 11.8 +/- 7.8, P <0.001; 4.2 +/- 4.3 vs 5.8+ /-4.2, P <0.05; 2.1 +/- 0.7 vs 2.6 +/- 1.3, motsatana). Timaganiza kuti hypothetosteronemia ya ED odwala ndi chifukwa chosowa chithandizo cha LH. Izi zachepetsa kuchepetsa kugonana ndizokhazikitsidwa, kupatula ngati kuyambiranso kugonana kumatheka ngakhale popanda chithandizo chamankhwala. Chifukwa chakuti biopotency ya mahomoni amatsitsimutso imayang'aniridwa ndi hypothalamus, LH kusalabadira kumayenera chifukwa cha kuwonongeka kwabwino kwa thupi komwe kumagwirizanitsidwa ndi kusokonezeka kwa maganizo kumene mosakayikira kumatsatira kusagwirizana ndi kugonana.

MAFUNSO: Olemba amati kupititsa patsogolo kugonana kumawonjezera LH ndi testosterone mwa amuna omwe amatsata ED. Palibe mmodzi wa amuna abwino omwe anachitidwa ndi mahomoni, ndipo otsika testosterone sanali chifukwa cha ED. Ngati ndi zoona kwa amuna abwino, izi zikusonyeza kuti kugonana / kuthamanga kungalepheretse kuchepa kwa magulu a testoterone.

ZOCHITIKA PAKATI PA MAFUNSO NDI MAFULU A NKHANI ZOKHUDZA KWAMBIRI KUCHITA MALAMULO

Scand J Psychol. 2003 Jul;44(3):257-63.

Fernández-Guasti A, Rodríguez-Manzo G.

Kudalirika

Nkhani yamakono ikufotokoza zomwe zapeza tsopano pa zochitika zosangalatsa za kugonana. Knut Larsson mu 1956 adafotokoza za kukula kwa kugonana kwa amuna amphongo pambuyo pobwereza. Taphunzira njirayi ndikupeza zotsatira zotsatirazi.

(1) Tsiku lina pambuyo pa maola a 4 a malingaliro a libitum, awiri mwa magawo atatu a anthu adasonyeza kuletsa kwathunthu khalidwe la kugonana, pamene gawo lina lachitatu likuwonetsa mndandanda umodzi wosasintha.

(2) Mankhwala amachiritso amodzi, kuphatikizapo 8-OH-DPAT, yohimbine, naloxone ndi naltrexone, amatsutsana ndi kugonana kumeneku, kusonyeza kuti njira za noradrenergic, serotonergic ndi opiate zikugwira ntchitoyi. Zoonadi, kulumikizana kwa matenda a ubongo kumasonyeza kusintha kwa matenda osiyanasiyana pa nthawi ya kugonana.

(3) Chifukwa chokakamizidwa mokwanira, mwa kusintha chisokonezo cha amayi, kugonana kwapakati kunaloledwa, kuwonetsa kuti pali zifukwa zolimbikitsa zogonana zomwe zimaonetsa kugona kwa kugonana.

(4) GABA yemwe amatsutsana ndi bicuculline, kapena kukakamizidwa kwa magetsi kwa malo apakati, sanagwirizanitse kugonja kwa kugonana. Deta izi zimasonyeza kuti kugona kwa kugonana ndi nthawi ya postejaculatory (yomwe yafupikitsidwa ndi bicuculline administration) sichiyanjanitsidwa ndi njira zofananamo, ndipo zina, kuti malo amodzi omwe sagwirizane nawo sagwirizanitsa kugonana.

(5) Kulingalira kwa a androgen m'madera a ubongo okhudzana kwambiri ndi machitidwe achiwerewere, monga chikhalidwe choyambirira, chinachepetsedwa kwambiri ndi nyama zowonongeka. Kuchepetsa koteroko kunali kovuta ku malo ena a ubongo ndipo sikunagwirizane ndi kusintha m'magulu a androgens. Zotsatira izi zimasonyeza kuti kusintha kwa ubongo ndi androgen receptors account pofuna kuletsa khalidwe la kugonana pakadutsa kugonana.

(6) Kukhazikitsidwa kwa chiwerewere pambuyo pa maola a 4 a malingaliro a libitum amasonyeza kuti, pambuyo pa masiku a 4, 63% yokha ya amuna amatha kusonyeza khalidwe la kugonana patatha masiku 7 nyama zonse zikuwonetsa ntchito yowonongeka.

MAFUNSO: Mbali ya ubongo komwe kuchepa kwa phwando kumakhala kofanana kwambiri ndi zinyama zonse. Ngati kugwa kwa testosterone amalandila amapezeka mwa amuna, zikhoza kufotokoza chifukwa chake amuna ena amamverera ngati testosterone yawo ili yochepa pakapita nthawi, ndipo chifukwa chake amamverera ngati testosterone yawo imakhala ndi nthawi yodziletsa.

ZOYENERA: Kusintha kwa kanthawi kochepa kumeneku kumayesedwa mu ubongo wamba. Ngati ubongo wanu wasintha chifukwa cha kuledzeretsa, dopamine yanu imayambanso kusokonekera, mwinamwake osati kuchepa kwa testosterone receptors, ndipo mudzafunika nthawi yaitali kuti mubwererenso ku libido.

Komanso: # 4 - Kutopa ndi kugonana kunalephereka poyambitsa mkazi wachikazi (ndizomwe zolaula zimachita).

Kuwonjezeka kwa estrogen receptor alpha immunoreactivity mu makina a makoswe opatsirana pogonana.

Horm Behav. 2007 Mar; 51 (3): 328-34. Epub 2007 Jan 19.

Phillips-Farfán BV, Lemus AE, Fernández-Guasti A.

Kudalirika

Alpha Estrogen receptor alpha (ERalpha) amagwira ntchito mu lamulo lachidziwitso la khalidwe lachiwerewere la amuna, makamaka m'madera a ubongo omwe ali mu limbic system. Amuna amitundu yambiri amachititsa chizolowezi chogonana patatha nthawi zingapo, zotchedwa kugonana. Zasonyezedwa kuti nthenda yowonongeka ndi androgen yafupika 24 h pambuyo pa kukamwa kapena kukwatira kamodzi kokha, m'dera loyambirira, malo oyambira accumbens ndi ventromedial hypothalamus. Cholinga cha phunziroli chinali kufufuza ngati kuchulukitsa kwa ERalpha kunasinthidwanso 24 h pambuyo pa kukamwa kapena kukakamiza kumodzi. Kugonana kumagwirizanitsa ndi kuchuluka kwa mphamvu ya ERalpha m'kati mwa bedi la stria terminalis (BSTMA), laserrolateral septum (LSV), amygdala apakati (MePD), omwe ali ndi malo apakati (MPA) ndi nucleus accumbens core (NAc). Kusindikiza kamodzi kunakhudzana ndi kuwonjezeka kwa mphamvu ya ERalpha mu BSTMA ndi MePD. Mlingo waukulu wa ERalpha mu arcuate (Arc) ndi ventromedial hypothalamic nuclei (VMN), ndipo maselo a serum estradiol sanasinthidwe 24 h pambuyo pa kuthamanga kapena kukwatira. Deta iyi imasonyeza ubale pakati pa kugonana ndi kuwonjezeka kwa kufotokozera kwa ERalpha m'madera ena a ubongo, mopanda mawonekedwe a estradiol mu kayendedwe kake.

MAFUNSO: Estrogen receptors density imawonjezeka m'madera angapo pokhapokha kutayika, komanso kugonana. Mu phunziro lathunthu iwo amati kusintha uku kumatenga nthawi yayitali kuposa 24 hrs.