Zakudya zamtengo wapatali kuphatikizapo kusowa chakudya kumapangitsa kuti anthu azidya zakudya komanso amasonyeza kuti anthu omwe amamwa mankhwalawa ndi ovuta. (2016)

Chitsanzo cha mbewa chagwiritsidwa ntchito kuti aphunzire zotsatira za mafuta odyera pamodzi ndi zakudya zowonongeka pa zakudya zopatsa thanzi komanso poyerekeza ndi anthu atatu omwe angakhale oledzeretsa mu nucleus accumbens: fumarate hydratase (FH), ATP synthase subunit alpha (ATP5a1) ndi transketolase (TKT). Mayi makumi anayi a C57BL / 6 J amphongo aamuna anayi, omwe anali ndi masabata anayi, adadyetsedwa ndi zakudya zamtengo wapatali (HF) kapena zakudya zoyenera panthawiyi. Pambuyo pa masabata a 3 odyetserako zakudya zosiyanasiyana, nyama zimaphunzira masabata awiri a tsiku ndi tsiku pomwe zakudya zowonongeka zinkagwiritsidwa ntchito pa chakudya (chokoleti) kapena chakudya. Maphunzirowa adapitilira patangotha ​​sabata imodzi yokha ndi zofanana, tsiku limodzi tsiku lotsatira ndi maola a 12 osowa chakudya. Kuyesedwa kwa khalidwe kunatsirizidwa kumene makoswe anali atatsekedwa kwa maminiti a 30 mwina m'zipinda zopanda chakudya kapena m'zipinda zomwe poyamba zinali zogwirizana ndi tirigu, koma tsopano ndi zida zopanda kanthu. Zochitika zonse pa kuyesedwa kwa khalidweli ndi se serum corticosterone pokhapokha zitakhala zofanana m'magulu onse oyesera. Manyowa omwe anayesedwa pazipinda zodyeramo chakudya adasonyeza kukonda kwachabechabechabe chachabechabe chomwe chinasweka pang'onopang'ono ndi anthu odyetsa zakudya koma anapitirizabe kukhala ndi makoswe odyetsa a HF. Nkhumba zodyetsedwa bwino za HF, FH, ATP5a1 ndi TKT, zomwe zimagwirizana kwambiri ndi kupitirizabe kwa chakudya chopanda kanthu. Zimalongosola kuti zakudya za HF kuphatikizapo kuchepa kwa zakudya zingapangitse khalidwe lofunafuna zakudya panthawi yomwe ikukakamiza FH / ATP5a1 / TKT, yomwe imatchulidwanso ngati anthu omwe amamwa mankhwala osokoneza bongo.