Ndemanga: Phunziro linayang'ana ma neurochemicals ambiri ndi mapuloteni ena okhudzana ndi kusuta kwa mankhwala. Kafukufuku adapeza kusintha komwe kumawonekera ndi zomwezo ndimakhalidwe omwe amapangidwira chakudya chamafuta kwambiri.
Int J Obes (London). 2012 Dec 11. doi: 10.1038 / ijo.2012.197.
Sharma S, Fernandes MF, Fulton S.
gwero
CRCHUM ndi Montreal Diabetes Research Center; Dipatimenti ya Zakudya Zopatsa Thanzi, Bungwe la Mankhwala, Université de Montreal, Montreal, Quebec, Canada.
Kudalirika
Cholinga:
Kuti muzindikire momwe zimakhalira ndi zomwe zimapangitsa kuti chakudya chizikhala chokwanira pambuyo poti wachotsedwa pakudya chamafuta kwambiri (HFD) ndikugwirizana ndi zochitika zomwe zimalumikizana ndi kusintha kwa mitsempha komanso machitidwe.
Njira:
Akuluakulu amuna C57Bl6 mbewa ifeyokhazikika pa HFD (58% kcal mafuta) kapena yogwirizanitsa, zakudya zamafuta ochepa (LFD; 11% kcal fat) kwa masabata a 6. Pamapeto pa mbewa-regimen mbewa zimasungidwa pazakudya zawo, kapena HFD ndi LFD zidasinthidwa ndi zovomerezeka.
Wogwira ntchito wogwiritsa ntchito kuyesera kwa sucrose ndi zakudya zamafuta ambiri amayeza limodzi ndi zoyambira za corticosterone komanso nkhawa zoyambira (zowonjezera-maze). Mitengo yama protein ya tyrosine hydroxylase (TH), corticosterone yotulutsa chinthu cha 1 receptor (CRF-R1), ubongo yochokera ku neurotrophic factor (BDNF), phospho-CREB (pCREB (pCREB) ndi ΔFosB (truncated splice variant of FosB) idayesedwa mu FosB. , nucleus accumbens (NAc) ndi dera lachigawo chodutsa (VTA) kudzera kumadzulo kwa immunoblotting.
Results:
Masabata asanu ndi limodzi a HFD amachititsa kuti thupi likhale ndi chidwi kwambiri, azikhala ndi nkhawa komanso azikhala ndi nkhawa komanso azikhala ndi nkhawa. Kuchotsedwa pa HFD koma osati LFD-nkhawa zomwe zingakhalepo ndi kuchuluka kwa basal corticosterone komanso kulimbikitsidwa kwakukonda kwa sucrose ndi mphotho yazakudya zambiri.
Kudyetsa kwamafuta kwambiri kumachepetsa CRF-R1 ndikuchulukitsa mapuloteni a BDNF ndi pCREB ku amygdala ndikuchepetsa TH ndi kuchuluka kwa protein ya ΔFosB ku NAc ndi VTA. Mphotho yayikulu yolandirika mu mbewa zochotsedwa ku HFD zophatikizana ndi kuchuluka kwa mapuloteni a BDNF ku NAc ndikuchepetsa TH ndi pCREB m'mawu amygdala.
Kutsiliza:
Anhedonia, nkhawa ndi chidwi cha opsinjika chimachitika nthawi ya HFD ndipo imatha kukhala ndi gawo lofunikira kwambiri pakazungulira koipa komwe kumapangitsa kudya mafuta kwambiri komanso kunenepa kwambiri.. Kuchotsedwa kwa HFD kumawonjezera mayankho a kupsinjika ndikuchulukitsa chiopsezo cha zakudya zabwino chifukwa chochulukitsa chakudya chopangitsa chidwi. Kusintha kosatha kwa ma dopamine komanso maukadaulo okhudzana ndi pulasitiki m'mayendedwe olipiritsa kungalimbikitse malingaliro osautsa, kudya moperewera komanso kusangalatsa kwa chakudya.
International Journal of Obesity patsogolo pa intaneti, 11 December 2012; doi: 10.1038 / ijo.2012.197.
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