Biol Psychiatry. 2015 Dec 2. pii: S0006-3223 (15) 00996-8. doi: 10.1016 / j.biopsych.2015.11.019.
Brown RM1, Kupchik YM2, Spencer S3, Garcia-Keller C4, Spanswick DC5, Lawrence AJ6, Simonds SE5, Schwartz DJ3, Jordan KA3, Jhou TC3, Kalivas PW3.
Kudalirika
MALANGIZO:
Pali umboni wowonjezereka woti kuchuluka kwa kunenepa kwambiri komwe kumapangitsa munthu kunenepa kwambiri kumakakamizidwa mwachilengedwe motero kuli ndi zinthu zina zomwe zimapangitsa kuti munthu azidwala. Komabe, umboni wakuthupi wakuthupi womwe umagwirizanitsa kunenepa kwambiri ndi kuphatikizika kwa mapuloteni monga momwe zimakhalira pakulowerera zakusowa. Tidayesetsa kudziwa ngati kuchuluka kwa kunenepa kwambiri (DIO) kumalumikizidwa ndi chizolowezi chofanana ndi zovuta, komanso kuwonongeka kwa synaptic mu nucleus accumbens pachimake komwe kumawoneka ngati chizindikiritso cha kusuta.
ZITSANZO:
Makoswe a Sprague Dawley adaloledwa kulowa pazakudya zaulere kwa masabata a 8 omwe adasiyanitsidwa ndi kuwonjezeka kulemera mumagulu ocheperako a DIO. Kufikira chakudya chabwino kumangolekeredwa kwa magwiridwe antchito ogwiritsa ntchito tsiku ndi tsiku pogwiritsa ntchito kuchuluka kwa 1, 3, ndi 5 komanso magawo omwe amapita patsogolo. Pambuyo pake, ma nyukiliya amachepetsa magawo aubongo anakonzedwa, ndipo tinayesa kusintha kwa kuchuluka pakati pa α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) ndi ma N-methyl-D-aspartate mafunde kuwonetsa kukhumudwa kwakanthawi.
ZOKHUDZA:
Tidapeza kuti kukula kwa DIO kumalumikizidwa ndi kuperewera pakukakamiza kupsinjika kwanthawi yayitali mu ma nucleus accumbens, komanso kuchuluka kwamphamvu pazinthu izi zomwe zimayesedwa ndi ma AMPA / N-methyl-D-aspartate mafunde. Molingana ndi zovuta izi, tidawona machitidwe achizolowezi mu makoswe a DIO, kuphatikiza 1) chidwi cholimbikitsa chakudya chabwino; 2) kudya kwambiri; ndi 3) kuchulukitsa kufunafuna chakudya pamene chakudya sichikupezeka.
MAFUNSO:
Zotsatira zathu zikuwoneka pakati pa kuchuluka kwa DIO ndi kusintha kwa ma synaptic komwe kumalumikizidwa ndi mbali zina zamankhwala osokoneza bongo, kuthandizira pang'ono pang'ono zovuta zamitsempha zokhudzana ndi kudya kwambiri komanso kugwiritsa ntchito mankhwala osokoneza bongo.
MAFUNSO:
Zakudya zotere; Glutamate; Kupsinjika kwanthawi yayitali; Mitsempha ya nyukiliya; Kunenepa kwambiri; Synaptic plasticity