Neuropsychiatr Dis Treat. 2019 Meyi 8; 15: 1211-1229. doi: 10.2147 / NDT.S204818.
Wei NL1,2, Kukula ZF3,4, Zhao T.1, Yu XD4, Xie Q1, Zeng J.1, Ma FK1, Wang F1, Mtengo QS1, Wu H3, Zhu JH1.
Kudalirika
Background: Kunenepa kwambiri chifukwa chokhala ndi nkhawa kumatha kukhala komwe kumakhudzana ndi kukakamiza kwa Hypothalamic-pituitary- adrenocortical axis komanso kukanika kwa kagayidwe kazinthu. Kupsinjika kwakanthawi kumathandiziranso kukayika kwa njira yamalipiro ndikukulitsa chiwopsezo cha kusowa kwa chakudya, malinga ndi zomwe apeza m'chipatala posachedwapa. Komabe, Kafukufuku ochepa adayesa zotsatira za kupsinjika kwakukulu pakukonda zakudya mu mitundu ya nyama.
Cholinga: Cholinga cha phunziroli chinali kudziwa ngati kupsinjika kwakanthawi kumalimbikitsa kusowa kwa zakudya kapena ayi ndikuwunika njira zomwe zingatheke.
Njira: Tinkayika mafuta a 2 hans tsiku ndi tsiku kupsinjika kwa magetsi a LED kuti mbewa zodyetsedwa chakudya kapena zakudya ziziyenda bwino kutsanzira zovuta za kudya. Pambuyo pa mwezi wa 1 wokhala ndi nkhawa yayikulu, tinayesa kudya, kulakalaka zakudya zabwino, mayankho azakudya zabwino, komanso zizolowezi zomwe timakakamiza kudya kuti tiwone momwe zingakhalire pamavuto akudya. Tazindikira kusintha kwamitundu ndi ma protein ambiri mu ma nyukiliya (NAc), malo a ventral tegmental (VTA) ndi lateral hypothalamus pogwiritsa ntchito qPCR ndi ma immunofluorescence stain, motsatana.
Results: Zotsatira zaku Behaviors zikuwonetsa kupsinjika kwakanthawi mwachidziwikire kumawonjezera gawo la chakudya chamagulu (FAS) mu mbewa zosavuta kudya. Kuphatikiza apo, FAS inali ndi ubale wolimba ndi kuchuluka kwa kuchuluka kwa thupi. Kupsinjika kwakanthawi kumakulitsa mawu a corticotropin-releasing factor receptor 1 (CRFR1) adakulitsidwa mu chipolopolo cha NAc komanso pakati koma adatsikira mu VTA ya mbewa yodyetsedwa ndi chakudya chosavuta. Kupsinjika kwakanthawi kumakulanso kufotokoza kwa onse a dopamine receptor 2 (DR2) ndi mu-opioid receptor (MOR) mu NAc.
Kutsiliza: Kupsinjika kwakanthawi kumakulitsa FAS ndikuthandizira kukulitsa kunenepa kokhudzana ndi kupsinjika. Kupsinjika kwakanthawi kumayambitsa kusowa kwa njira ya CRF yosonyeza njira yolipira ndi kukulitsa mawu a DR2 ndi MOR mu nucleus accumbens.
MAFUNSO: kupsinjika kwa nthawi yayitali; dopamine receptor 2; chakudya; mu-opioid receptor; ma nucleus accumbens; kunenepa
PMID: 31190828
PMCID: PMC6512647