Mol Genet Genomics. 2015 Aug;290(4):1191-221. doi: 10.1007/s00438-015-1015-9.
Albuquerque D1, Stice E, Rodríguez-López R, Manco L, Nóbrega C.
Kudalirika
Ndizodziwika bwino kuti kunenepa ndikumvetsa kovuta komanso kosiyana kwambiri ndi chiwalo chofunika kwambiri. Posachedwapa, kupita patsogolo kwakukulu pa kafukufuku wokhutiritsa kunenepa kunachitika ponena za njira za maselo zomwe zimapangitsa kuti thupi likhale lolemera kwambiri. Ndemangayi imapereka maphunziro ndi deta zingapo zokhudzana ndi ma genetic ndi zina zomwe zimayambitsa chiopsezo chofuna kunenepa kwambiri. Kuchokera mu zolemba zamtundu wambiri zamagulu mitundu itatu ya kunenepa kwambiri imalingaliridwa: kugonana kwachibadwa, matenda osokoneza bongo, ndi kunenepa kwambiri. Chifukwa cha kunenepa kwambiri kwa thupi, jini yomwe imachititsa kuti phenotype izidziwike bwino, koma chifukwa cha kunenepa kwambiri kwina kumangidwa kwapangidwe ka phenotype. Chifukwa chaichi, muwongolera uwu timayang'ana makamaka mu mawonekedwe a kunenepa kwambiri, kubwereza zolemba zomwe zimapezeka mpaka tsopano ndi maphunziro a bungwe losiyanasiyana lomwe limagwirizana ndi chiopsezo chotenga kunenepa kwambiri. Kuwonjezera apo, timafotokozanso momveka bwino za ana okhudzana ndi kunenepa kwambiri kwa ana ndi mafuko osiyanasiyana, kuyesera kufotokozera zovuta za ma genetic zomwe zimagwirizanitsa zochitika zowonjezereka. Chofunika kwambiri, timaganiziranso zozizwitsa zomwe zatsimikiziridwa kuyesera kufotokoza momwe kusankhidwa kwa chilengedwe kunayendera kufalikira kwa majini omwe amachititsa kuti pakhale nthendayi yochulukirapo komanso momwe izi zimakhudzira kunenepa kwambiri. Zinthu zina ndizofunika kwambiri pa vuto la kunenepa kwambiri, ndipo motero, timakambirananso njira zomwe zimapangitsa kuti kunenepa kwambiri kukule bwino. Kuphimba mitu yonseyi tikuyembekeza kupereka zenizeni ndi zam'tsogolo zokhudzana ndi njira zowonjezereka zomwe zikukhudzana ndi chitukuko ndi chiyambi cha kunenepa kwambiri. Pokhapokha mutamvetsetsa bwino zinthu ndi njira zomwe zimapangitsa kuti mukhale wonenepa kwambiri, zingatheke kupereka ndi kulola chitukuko cha njira zatsopano zothandizira matendawa.
PMID: 25749980
DOI: 10.1007/s00438-015-1015-9