Neuroscience. 2005;134(3):737-44.
Kudalirika
Mankhwala osokoneza bongo ambiri amachulukitsa dopamine (DA) mu nucleus accumbens (NAc), ndipo amachita nthawi iliyonse ngati mankhwala. Chakudya chokhalitsa chimatulutsanso DA, koma mu makoswe amadzimadzi amatha kupweteka pa nthawi yayitali ndipo amatha kubwereza. Mukasankha zakudya, shuga ikhoza kukhala ndi zotsatira zofanana ndi mankhwala osokoneza bongo. Makoswe amasonyeza zizindikiro za kudandaula kwa DA ndi kudalira kwa opioid akamapatsidwa mwayi wothandizana ndi sucrose, monga kusintha kwa DA ndi ma-opioid receptors, kuwalimbikitsa kwambiri ndi amphetamine ndi mowa, ndi zizindikiro za khalidwe ndi zokhudzana ndi matenda a nexone. Kafukufukuyu akufunsa ngati makoswe otetezedwa ndi sucrose amamasula DA nthawi iliyonse akamadya. Timaloseranso kuti acetylcholine (ACh), yomwe imatuluka ngati mapeto a chakudya, idzachedwa kuchedwa ndi makoswe ndi mwayi wopita ku sucrose. Kuti apange kudalira, gulu loyesera (Daily Intermittent Sucrose) linasungidwa pa chakudya cha 12-h chakudya chomwe chinapangitsa 4 h ku mdima, kenaka ndi 12-h kulandira 10% sucrose solution ndi chow, tsiku ndi tsiku, kwa 21 masiku. Monga zotsatira zake, pang'onopang'ono makoswewa anawonjezereka kudya kwa sucrose kuchokera ku 37 mpaka 112 ml tsiku (kuchokera 13 mpaka 20 ml mu ola loyamba la kupeza), ndipo mobwerezabwereza anawonjezera DA extracellular kwa 130% ya mzere woyamba monga momwe anawerengera mu NA shell microdialysis pa ola loyamba la sucrose kupeza tsiku 1, tsiku 2 ndi tsiku 21. Magulu atatu olamulira sanathe kuwonetsa kuwonjezeka kwakukulu kwa DA ya extracellular pa tsiku 21: Sucrose kokha kwa 1 h pa masiku 1 ndi 21 (Sucrose Twice), kulumikizana ndi sucrose ndi chow (Daily Ad libitum Sucrose), ndi chow intermittent chow mmalo mwa Daily Intermittent Chow. Acetylcholine imayeza nthawi imodzimodzimodzi ndi DA, yowonjezera kwambiri mpaka kumapeto ndipo pambuyo pa mayesero aliwonse m'magulu onse.
M'magulu a Daily Intermittent Sucrose, akuluakulu a ACh (133%) anachitika panthawi yoyamba yopereka chakudya cha sucrose. Mwachidule, zinyama zokhudzana ndi sucrose zimayimitsa kuyankha kwa ACh, kumwa mowa kwambiri sucrose, ndi kumasula DA wambiri kuposa asprose- kapena nyama zodzikuza, koma osadalira. Zotsatira izi zimaphatikizapo kufanana kwa ubongo wamkati pakati pa zakumwa za sucrose ndi mankhwala osokoneza bongo: zonsezi zikhoza kuwonjezereka DA extracellular mu chipolopolo cha NAc.
PMID: 15987666
DOI: 10.1016 / j.neuroscience.2005.04.043