Psychopharmacology (Berl). 2012 Mar;220(1):173-81. doi: 10.1007/s00213-011-2468-0.
Finger BC1, Dinan TG, Cryan JF.
Kudalirika
RATIONAL:
Ndondomeko ya ghrelinergic imaphatikizapo kupititsa patsogolo kunenepa kwambiri komanso kuwonetsa kayendedwe ka mphoto. Zakhala zikugwiritsidwa ntchito kuti zakudya zowonongeka zimapangitsa kuti anthu asamayambe kudya zakudya zogwiritsa ntchito ghrelin administration, zogwirizana ndi ghrelin kukana. Pano ife tikufufuza ngati zotsatira zowonjezera za ghrelin pa dongosolo la mphotho zimasinthidwa mu zakudya zowonongeka kwambiri.
ZITSANZO:
Kunenepa kunaphatikizidwa mu mbewa za C57BL / 6J mwa kudyetsa zakudya zamtengo wapatali kwa masabata a 13. Mphungu zinaphunzitsidwa pa chiwerengero chokhazikika chodziwika bwino choyenera kuti chiyankhidwe m'malo mwa sucrose mphoto. M'madera odyetsera ad libitum, ghrelin ndi wotsutsa ghrelin receptor ankaperekedwa mu chiŵerengero chofulumira. Kusinthika pakatikati pa ghrelin dongosolo mu zakudya zomwe zimapangitsa kuti mbewa zowonongeka ziyesedwe.
ZOKHUDZA:
Mphungu zowonongeka zinkachititsa kuti phindu likhale lopanda ntchito komanso kuti likhale lopambana pa chiwerengero cha paradigm. Chofunika kwambiri, kudyetsa kunenepa kwa zakudya kunalepheretsa zotsatira zowonongeka za ghrelin (2 nmol, 3 nmol / 10 g) pang'onopang'ono chiwerengero poyankha koma nyama zowonda zowonjezera kuyankha. Kulamulira kwa wotsutsana ndi ghrelin-receptor (D-Lys (3)) - GHRP-6 (66.6 nmol / 10 g) adachepetsa ntchito yowonda koma osati wamba. Kusamvera kwa ghrelin receptor ligands mu mbewa pa zakudya zapamwamba kwambiri kunathandizidwa ndi kuchepa kwa mawu a mRNA a ghrelin receptor mu hypothalamus ndipo nucleus accumcums mu obese mbewa.
MAFUNSO:
Kafukufukuyu akuwonetsa kuti zotsatira zowonongeka za ghrelin receptor ligands zimayambitsidwa mu chitsanzo cha mbewa cha zakudya zowonongeka zowonongeka m'kupita patsogolo kwa ntchito. Potero, deta yathu imaphatikizapo kukana kutsogolo kwa ghrelin mu makoswewa kuchokera ku chakudya chokhudzana ndi khalidwe logwirizana.
PMID: 21892647
DOI: 10.1007/s00213-011-2468-0