Kuwonjezera pa chakudya chokoma chodyetserapo zakudya kumasintha maonekedwe a jini m'madera a ubongo omwe amawathandiza kuti apereke mphotho, ndipo kuchoka ku zakudya zimenezi kumasintha maonekedwe a jini m'madera a ubongo okhudzana ndi nkhawa (2014)

Mofanana ndi anthu, makoswe amagwiritsidwa ntchito ku zakudya zowonjezera-kudya ndi kukhala olemera kwambiri. Kuchotsa chakudya chimenechi kumapangitsa kuti anthu azivutika maganizo, zomwe zingafotokoze chifukwa chake anthu amavutika kudya.

Tinavumbulutsira makoswe ku zakudya zopatsa mphamvu kuti tipeze kusintha kwa ubongo chifukwa cha chakudyacho ndi kuchotsedwa kwake. Kudzudzula makoswe a Dawley anadyetsedwa lab-chow kapena zakudya zopatsa thanzi (kuphatikizapo chow). Pambuyo pa masabata a 6 kapena 15, theka la gulu lirilonse linasinthidwa ku chakudya chotsutsana. Makoswe adayambitsidwa 48-h pambuyo pake. Tinayesa mafuta, mahomoni a plasma, ndipo tinayesedwa ubongo kwa maRNA ambiri. Makoswe odyetsa zakudya amadya kwambiri ma kilojoules, olemerera kwambiri ndipo adakweza leptin (kuphatikizapo CORT kuchepetsedwa pa masabata a 15) ndi makoswe odyetsedwa.

Zakudya khumi ndi zisanu ndi zisanu ndi zitatu za zakudya zodyera zakudya zathandizira μ-opioid ndi CB1 receptor mRNA mu VTA, koma amygdala GR, ndi masabata a 6 odyera zakudya akuchepetsa BDNF, poyerekeza ndi makoswe odyetsedwa. Makoswe amasinthana ndi zakudya zodyera ankadya mofanana ndi makoswe omwe amasungidwa pa chakudya, ndipo kusinthana ndi zakudya zakudya pambuyo pa masabata a 15 kunachepetsa amygdala GR kulankhula.

Makoswe amasintha kuti adye osadya makoswe osungidwa pa chow, ndipo kusintha kwa masabata a 15 akudya zakudya zowonjezera kunawonjezeka hypothalamic CRH mRNA.

Choncho, masabata a 15 a zakudya zodyera amatulutsa kusintha m'madera a ubongo okhudzana ndi mphoto. Kusintha makoswewa kuti asinthe majekiti a HPA, pamene kusinthasintha makoswe odyetsedwa ku chakudya cha zakudya kunachepetsedwa ku GR poyankhula mu amygdala, dera lomwe limagwirizanitsa ndi nkhawa. Zotsatirazi zimakhudza kudya kwa anthu.