Mavitamini. 2015 Meyi 22; 7 (5): 3869-90. doi: 10.3390 / nu7053869.
Levy A1, Marshall P2, Zhou Y3, Kreek MJ4, Kent K5, Daniels S6, Phokoso A7, Downs T8, Fernandes MF9, Mutch DM10, Leri F11.
Kudalirika
Kafukufukuyu adafufuza ngati magawo osiyanasiyana a fructose (F) ndi glucose (G) mu shuga angapangitse kusiyana kwakukulu pakudziyendetsa pakokha komanso mayankho okhudzana ndi mitsempha komanso yokhudza thupi mu makoswe a amuna a Sprague-Dawley. Muyesera 1, nyama zolembera zokha zokhala ndi 55% F + 45% G kapena 30% F + 70% G, ndipo Fos immunoreactivity idayesedwa m'magawo a hypothalamic omwe amawongolera kudya ndi mphotho. Mu Experiment 2, makina odziyendetsa okha a 55% F + 42% G (high fructose corn syrup (HFCS)), 50% F + 50% G (sucrose) kapena saccharin, ndi mRNA ya dopamine 2 (D2R) ndi Mitundu ya receptor ya mu-opioid (MOR) idayesedwa m'malo omwe anthu amakhala nawo akuchita zikhalidwe zowonjezera. Pomaliza, mu Experiment 3, makoswe amadziyendetsa okha HFCS ndi sucrose m'nyumba zawo, ndipo mafuta achepatic anatha. Zinapezeka kuti kukwera kwa fructose ratios kumapangitsa kudzilamulira kwapansi, kutsitsa kwa Fos mu ofananira nawo hypothalamus / arcuate, kumachepetsa D2R ndikuwonjezera MOR mRNA mu dorsal striatum ndi nucleus accumbens core, motero, komanso mafuta okwera a omega-6 polyunsaturated acid mu chiwindi. TZotsatira za hese zikuwonetsa kuti kuchuluka kwa fructose kumathandizira kukula kwa shuga ndipo mwina kumabweretsa kusinthika kwa mitsempha ndi zokhudza thupi zomwe zimakhudzana ndi zovuta komanso zovuta zama metabolic.
MAFUNSO:
dopamine 2 receptor; mafuta acid; fructose; shuga; otupa; hypothalamus; mu opioid receptor; ma nucleus accumbens; khoswe; kudzilamulira
PMID: 26007337
PMCID: PMC4446784
DOI: 10.3390 / nu7053869