Behav Pharmacol. 2014 Apr;25(2):147-57. doi: 10.1097/FBP.0000000000000029.
Bocarsly ME1, Hoebel BG, Paredes D, von Loga I, Murray SM, Wang M, Arolfo MP, Yao L, Diamond I, Avena NM.
Kudalirika
Kudya zakudya zokoma kumasonyezedwa kukhala ndi machitidwe ofanana ndi okhudzana ndi mankhwala osokoneza bongo. GS 455534 ndi yosankha kwambiri aldehyde dehydrogenase 2 inhibitor yomwe yasonyezedwa kuchepetsa mowa ndi cocaine kudya mu makoswe. Chifukwa cha kugwedeza pakati pa kudya ndi kumwa mankhwala osokoneza bongo, tinayang'ana zotsatira za GS 455534 pa kudya zakudya zambiri komanso kumasulidwa kwa dopamine. Mphuno-Dawley makoswe ankasungidwa pa shuga (kuyesera 1) kapena mafuta (kuyesera 2) kudya zakudya. Pambuyo masiku a 25, GS 455534 inkaperekedwa ku 7.5 ndi 15 mg / makilogalamu ndi jekeseni la intraperitoneal, ndipo kudya koyenera kunayang'aniridwa. Poyesera 3, makoswe okhala ndi cannulae omwe amawoneka pamtundu wa nucleus accumbens shell ankasungidwa pa shuga wodya shuga kwa masiku a 25. Microdialysis inkachitika, pamene GS 455534 15 mg / kg inkaperekedwa, ndipo shuga inalipo. Zojambula za Dialysate zinasanthuledwa kuti zizindikire mayendedwe a extracellular a dopamine. Poyesera 1, GS 455534 yatsala pang'ono kuchepetsa shuga kudya chakudya chinkapezeka mu Binge Sugar gulu koma osati Ad libitum Sugar gulu, popanda zotsatira pa chow kudya. Poyesera 2, GS 455534 inachepetsa mafuta mu gulu la Binge Fat, koma osati gulu la Ad libitum Fat, komabe linachepetsanso chakudya cha chow. Poyesera 3, GS 455534 imakhala yowonongeka kuti imatulutsa dopamine kumasulidwa ndi pafupifupi 50% podya kudya makoswe poyerekezera ndi jekeseni ya galimoto. Zomwe anapezazi zikusonyeza kuti aldehyde dehydrogenase 2 inhibitors yosankhidwa yosasinthika ikhoza kukhala ndi mphamvu zothandizira kuchepetsa kudya zakudya zowonjezereka m'zipatala.
PMID: 24603339