Chiwerewere. 2015 May 26. onetsani: 10.1111 / adb.12270.
Reynaert ML1,2, Marrocco J3, Mairesse J1,2, Lionetto L4, Simmaco M4, Deruyter L1,2, Allorge D5, Ma Moles A6,7, Pittaluga A8, Maccari S1,2, Morley-Fletcher S1,2, Van Camp G1,2, Nicoletti F1,2.
Kudalirika
Chakudya chogwiritsidwa ntchito ndizomwe zimayambitsa zowonjezera mphoto ndipo zingayambitse khalidwe losokoneza bongo lomwe limayambitsa matenda. Zochitika zakale za moyo ndi kugonana zogwirizana pakupanga hedonic kukhudzidwa ndi chakudya chokoma ndizosaidziwika. Tinkagwiritsira ntchito makoswe (RPS), zomwe zimasonyeza kuti sizinali zachilendo muzolowera mphoto komanso khalidwe lopweteka / lachisoni. Zina mwa zizindikiro za ntchentche za PRS zimadziwika kuti zimadalira kugonana. Timalengeza kuti PRS imapititsa patsogolo komanso imachepetsanso malo amtundu wa chokoleti wa mkaka mwa amuna ndi akazi, motero. Mankhwala a PRS amasonyezanso kuwonjezeka kwa magulu a dihydrotestosterone (DHT) ndi dopamine (DA) m'magulu a nucleus accumbens (NAc), ndi kuchepetsa zigawo za 5-hydroxytryptamine (5-HT) ku NAc ndi prefrontal cortex (PFC). Mu makoswe amphongo, chithandizo chamakono ndi mankhwala a DHT-kuchepetsa mankhwala osokoneza bongo amachepetsa makasitomala onse a chokaka ndi mkaka wa NAC DA.
Mphungu ya PRS yazimayi inkaonetsa m'munsi mwa plasma estradiol (E2 ) Maseŵera ndi kuchepetsa mayeso a DA mu NAC, ndi ma 5-HT m'magulu a NAc ndi PFC. E2 supplementation inachepetsa kuchepetsa mkaka wa chokoleti ndi mkaka wa PFC 5-HT. Mu hypothalamus, PRS inakula ERα ndi ERβ estrogen receptor ndi CARTP (cocaine-am-amphetamine receptor transcript peptide) mRNA pa amuna, ndi 5-HT2 C mlingo wa mRNA wa receptor kwa akazi. Kusintha kunakonzedwa ndi mankhwala ndi finasteride ndi E2 , motero.
Zotsatira zatsopanozi zikusonyeza kuti kupsinjika kwa moyo wa msinkhu kumakhudza kwambiri mphamvu ya hedonic ndi zakudya zabwino kwambiri zomwe zimakhala ndi kusintha kosatha kwa mahomoni. Izi zimapereka njira yopititsira patsogolo njira za mahomoni zomwe zimayesetseratu kukonza zolakwika poyankha madalitso achilengedwe.
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