Nutritional Neurosci. 2017 Apr 11: 1-9. yani: 10.1080 / 1028415X.2017.1313583.
Kim JY1, Kim D1,2, Park K3, Lee JH1, Jahng JW1.
Kudalirika
ZOLINGA:
Kafukufukuyu anachitidwa kuti aone zotsatira za kugonana kwapadera kwa chakudya chapamwamba kwambiri (HPF) pa nthawi ya unyamata pa ubongo ndi matenda / maganizo / maganizo ngati makoswe.
ZITSANZO:
Amuna ndi aakazi Sprague-Dawley pups anali ndi ufulu wopeza mafuta a chokoleti okhutira (HPF) kuyambira tsiku loperekera tsiku la tsiku la 28 kuphatikiza pa malonda a libitum chow, ndipo magulu olamulira adalandira chow. Momwe chakudyacho chinapitilira mu nthawi yonse yoyesera, ndipo miyendo ya m'magazi ndi machitidwe anachitidwa ali wamkulu. Makoswe anagonjetsedwa ku ntchito yogulitsira, kuwonjezereka ndi maze, ndi kukakamiza kusambira mayesero. Maselo a Corticosterone pa 2 h of stress stress anali analongosoka ndi radioimmunoassay, ndipo DFBB ndi ubongo-derived neurotrophic factor (BDNF) mawu mu nucleus accumbens (NAc) ndi Western kubwezeretsa.
ZOKHUDZA:
Kulowa kwa cooti sikudakhudze kulemera kwa thupi ndi kudya kwa caloric kwa onse awiri; Komabe, chinawonjezereka ndi mafuta otchedwa retroperitoneal fat deposot okha mwa amuna. Nthawi yomwe ankatambasula m'manja nthawi yayitali yowonjezera mayendedwe anali atachepetsedwa ndipo panthawi yomwe ankayesa kuyendetsa bwino anawonjezeka ndi amuna odyetserako nkhuku, koma osati amayi odyetsedwa. Kupambana kwa chikhalidwe cha zakudya pa kuwonjezeka kwa corticosterone kunapangidwira kwa amuna, koma osati kwa akazi, ndipo kuwonjezera kwa kuki kunayambira BDNF kufotokoza mu NAC mwa amuna okha.
MAFUNSO:
Kuwonjezeka kwa mawu a BDNF ku NAc ndi malo otetezera mafuta, kuphatikizapo vuto lopweteka, lingathe kugwira ntchito pa matenda ovutika maganizo / ndi / kapena nkhawa monga machitidwe okhudzana ndi zokopa.
MAFUNSO: Chithunzi; Kudya chakudya; Nucleus accumbens; Kusokonezeka maganizo
PMID: 28399791
DOI: 10.1080 / 1028415X.2017.1313583