Eur J Neurosci. 2015 Nov 3. yani: 10.1111 / ejn.13117.
Adams WK1,2, Sussman JL1, Kaur S1, D'souza AM3, Kieffer TJ3, Winstanley CA1,2.
Kudalirika
Kutengeka kwakukulu, komwe kunayanjanitsika kupyolera mu chidziwitso cha ventral strioper dopamine, kukuyimira chiopsezo chokhazikika chakumwa mowa mwauchidakwa ndipo kungachititse kuti pakhale chiopsezo cha matenda osokoneza bongo. Mwachidziwikiritso, lingaliro ndilokuti khalidwe lachidziwitso limapangitsa kuyambitsa mikhalidwe yosadya zakudya kapena zosankha. Komabe, kaya kumwa mowa mwauchidakwa kumayambitsa kusokoneza mwadzidzidzi komanso kuwonetsa kwapadera, moteronso kumapangitsa kusintha kwadzidzidzi kumalowetsa chizoloŵezi chodyera, sichiyenera kuganiziridwa.
Tidasanthula zovuta zakukhalitsa pakudya kofanana, koma mafuta kapena shuga wambiri, zakudya (48 kcal / tsiku; 60 kcal% mafuta kapena sucrose) pakugwira kwa makoswe mu 5-kusankha serial reaction time task (5CSRTT) kulozera chidwi ndi chidwi. Zolemba za dopamine zosonyeza mu dorsal ndi ventral striatum, ndi plasma insulin ndi leptin level, adayesedwanso. Makoswe omwe amadya zakudya zamafuta ambiri (HFD) anali opupuluma kwambiri, pomwe chakudya cha shuga wambiri (HSD) sichinasinthe magwiridwe antchito. Chofunika kwambiri, kulemera kwa thupi ndi kuchuluka kwama mahomoni zinali zofanana pakati pamagulu pomwe kusintha kwamakhalidwe kunkawonedwa. Kusamalira pa HFD, koma osati HSD, kuchepa kwa dopamine D.2 receptor (D2 R), mapulogalamu amphamvu omwe amapanga mapuloteni (CREB) ndi mapuloteni a phospho-CREB (ser133) mu ventral, koma osati povina, striatum. D2 Chilankhulochi mu ventral striatum chikuphatikizana kwambiri ndi kupanikizika kopanda zakudya.
Deta imeneyi ikuwonetsa kuti kupezeka kwa zakudya zam'mafuta kwambiri kungachepetse kulamulira kwachangu ndikusintha chizindikiro cha neural mwa njira yomwe ikukhudzana ndi chiopsezo cha zizolowezi zoledzera zomwe zimakhudza kwambiri kufalitsidwa kwa khalidwe losalamulirika la kudya ndi kunenepa kwambiri chisokonezo.