Behav Ubongo Res. 2017 Jul 14; 330: 46-55. yani: 10.1016 / j.bbr.2017.05.014.
Camacho A1, Montalvo-Martinez L2, Cardenas-Perez RE2, Fuentes-Mera L3, Garza-Ocaña L4.
Kudalirika
Makhalidwe oyenera okhudzana ndi zakudya amafunika kupangidwa ndi mapuloteni a glutamatergic mufupipafupi, kuphatikizapo kusintha kwa mawu monga amino-3-hydroxy-5-methylisoxazole 4-propionate receptors (AMPA), N-methyl-d-aspartic acid (NMDA) ) ndi metabotropic glutamate 2,3 (mGlur 2,3). Komabe, udindo wa kusintha kwa zizindikiro zamagetsi zamagetsi zamagetsi pazinthu zowonongeka zowonjezera mphamvu zopanda mphamvu sizinafotokozedwe. Pano, tikudziŵa zotsatira za mapulogalamu a zakudya panthawi yogwiritsira ntchito zakudya zamakono pogwiritsa ntchito mayeso okonda malo (CPP) ndikuyesa kuchitapo kanthu komanso zomwe zimapangitsa kuti zizindikiro za glutamatergic zikhale pa shell nucleus accumbens (Nac) ndi prefrontal cortex (PFC). Deta yathu inasonyeza kuti makoswe amavomereza chakudya chokoma chokoma ndi kuwonjezeka kwa kudya kwa caloric poyerekeza ndi chakudya cha chow. Zowoneka kuti, 74% ya makoswe omwe amasonyeza zokonda chakudya chokhala ndi mafuta ndi correlation yabwino ya HFD pamene 26% alephera kupeza HFD-conditioned. Komanso, ziphuphu zomwe zinaphunzitsidwa panthawi yophunzitsira (FR1, FR5 ndi PR) zinasonyeza magulu akuluakulu ndi otsika kuti agwire chakudya. Kuwoneka bwino, njira yowonjezera zakudya zamagulu azimayi amachititsa kuti kuwonjezereka kwazowonjezereka kwa ana aakazi poyerekeza ndi ana kuchokera ku chakudya cha chow. Pomalizira pake, tazindikira kuti kuphunzitsidwa kwa othandizira ena kumalumikizana ndi mGlur 2,3 mu NAC shell ndi PFC ya makoswe ndi ana aakazi. Komanso, tinapeza chisankho cha Nr1 ku NAC shell ndi PFC ya ana aakazi. Deta yathu ikuwonetsa kuti pulogalamu ya zakudya ndi hypercaloric kudya imalimbikitsa zolimbikitsa kugwira ntchito ndi chakudya ndi synaptic mapulasitiki kusintha mu mesolimbic dongosolo.
MAFUNSO: Malonda; Chiwonetsero cha malo; Zakudya zapamwamba kwambiri; Nucleus accumbens; mGlur2,3
PMID: 28487223
DOI: 10.1016 / j.bbr.2017.05.014