https://doi.org/10.1038/s41386-019-0550-1
- Catherine F. Moore,
- Michael Z. Leonard,
- Nicholas M. Micovic,
- Klaus A. Miczek,
- Valentina Sabino &
- Pietro Cottone
Neuropsychopharmacology (2019) |
Kudalirika
Khalidwe lodyera mokakamiza limayesedwa kuti liziyendetsedwa limodzi ndi zoperewera zomwe zimadza chifukwa cha neuroadaptations ku mesolimbic dopamine (DA) system. Chifukwa chake, cholinga cha phunziroli chinali kuyesa kuwongolera momwe magwiridwe antchito amagwirira ntchito ndi mesolimbic DA atasinthana chowonadi choyenera ndi zakudya zabwino, mtundu wa chakudya chokakamizidwa. Mu mtundu uwu, makoswe pagulu lolamulira (Chow / Chow) amapatsidwa chakudya choyenera masiku 7 pa sabata, pomwe gulu loyesera (Chow / chosangalatsaimaperekedwa kwa masiku 5 pasabata ("C C"), ndikutsatiridwa ndi masiku awiri ogulitsira zakudya zabwino kwambiri (“Phase”). Tidayesa koyamba kuzindikira d-Zowonjezera za Amphetamine, zolimbikitsa mphoto, ndi zotsatira zoyambira kugwiritsa ntchito njira ya locomotor, njira yodzifunira nokha (ICSS), ndi mayeso okonda malo, motsatana. Tidatsimikiza kutulutsidwa kwa DA mu chipolopolo cha nucleus accumbens (NAc) pambuyo pa chithandizo d-Amphetamine wogwiritsa ntchito mu vivo micodialysis, kuchuluka kwa tyrosine hydroxylase (TH) ndi dopamine transporter (DAT) mRNA pogwiritsa ntchito kuchuluka kwa polymerase chain reaction (qPCR), ndipo pomaliza, amafufuza zomangira zapakati pa DA ndi ntchito ya DAT mu vivo pogwiritsa ntchito kuchuluka kwa "no-net -flux ”ma micodialysis. Chow / chosangalatsa makoswe owonetsedwa d-Amphetamine-anachititsa locomotor ntchito, kupanda chidwi kwa d-Amphetamine potentiation of ICSS thirsth, ndikuchepetsa kukonda kwa d-Amphetamine nthawi ya Gawo. Tapeza kuti Chow / chosangalatsa makoswe anali ataphwetsa DA efflux kutsatira d-Chithandizo cha Amphetamine. Kuphatikiza apo, DAT mRNA idakulitsidwa Chow / chosangalatsa makoswe pa gawo la P. Pomaliza, kuchuluka kwa "no-net-flux" kwawonetsa kuchepa kwaposachedwa koyambira kwa DA ndi DAT kugwira ntchito mu Chow / chosangalatsa makoswe. Zotsatira zonse, izi zimapereka umboni wa magwiridwe antchito a mphotho ofunikira komanso magwiridwe antchito okhudzana ndi machitidwe a DA ndi DAT pamachitidwe awa a kudya mokakamiza. Zoperewera pamalipiro, zomwe zimabwera chifukwa chodya kwambiri, zimathandizanso kukulitsa chikhalidwe chamadyedwe.