Neuropsychopharmacology. 2018 Feb;43(3):617-626. doi: 10.1038/npp.2017.215.
Feltmann K1, Giuliano C2, Everitt BJ2, Steensland P1, Alsiö J2,3.
Kudalirika
Matenda Odyera BED (BED) amadziwika ndi nthawi zambiri zomwe zimadya chakudya chokoma komanso kuwonjezereka kwa chakudya. Odwala omwe ali ndi BED amasonyeza mankhwala ozunguza bongo komanso njira ya dopamine ikhoza kukhala chithandizo chamankhwala. Maselo otetezeka a monoamine stabilizer (-) - OSU6162 (OSU6162) amabwezeretsa vuto la dopaminergic m'zakumwa zakumwa kwa nthawi yaitali komanso amasonyeza kuti ndi mankhwala osokoneza bongo. Pano, zotsatira za OSU6162 zowonongeka (khalidwe lofuna kudya mowa) komanso chilakolako (kufunafuna chilakolako chofuna kudziletsa) chokhudzidwa ndi chokoleti cha chokoleti chokhazikitsidwa ndi chokoleti chinayesedwa mu makoswe aamuna a Lister Hooded osafuna kudya. OSU6162 kwambiri imachepetsa binge-monga kudya kwa chokoleti-flavored sucrose pellets popanda kukhudza choyambirira chow kudya. Kuwonjezera apo, OSU6162 inachepetsera kwambiri kufunafuna chofuna chokoleti cha chokoleti-flavored sucrose pellets pansi pa ndondomeko yachiwiri yothandizira kale, koma osati pambuyo pake, kubereka ndi kumeza kwa mphotho, zomwe zimasonyeza kusankhidwa komwe kumakhudza zolimbikitsa zomwe zimawathandiza. Mosiyana ndi zimenezi, dopamine D2 / D3 adpatist antopist raclopride adachepetsa kufunafuna chokoleti-flavored sucrose pellets zonse zisanayambe ndi mphotho yowonjezera komanso kuchepetsa kuyankha pansi pa ndondomeko zosavuta za kufunafuna khalidwe. SCH1 wotsutsa D5 / 23390 sankakhudzidwa ndi khalidwe lachida panthawi iliyonse yowonjezera yomwe amayesedwa. Pomalizira, kayendedwe ka OSU6162 m'kati mwa nucleus accumbens core, koma osati dorsolateral striatum, posankha kuchepetsa mankhwala omwe amachititsa sucrose. Pomalizira, zotsatira zake zikuwonetsa kuti OSU6162 imachepetsanso khalidwe lodyera komanso kuchepetsa zotsatira za kufuna chakudya chokoma. Izi zikusonyeza kuti OSU6162 ikhoza kukhala mankhwala a BED.
PMID: 28895569