Zotsatira zopindulitsa za ethanol zimayendetsedwa ndi kudya mowa kwambiri zakudya zapamwamba paunyamata (2017)

Kudya kwambiri kumawerengedwa kuti ndi njira yakudya mopitirira muyeso yodziwika ndi kudya kwapakatikati komanso kochuluka kwama caloriki munthawi yochepa. Kafukufuku wa Epidemiologic amathandizira ubale wabwino pakati pakulowetsedwa kwa mafuta ndi ethanol (EtOH), makamaka pakati pa achinyamata. Cholinga cha ntchitoyi chinali kufotokozera gawo la kudya mokakamiza, kochepa komanso kwakanthawi kochepa kwamafuta azakudya zambiri panthawi yachinyamata pazotsatira zabwino za EtOH. Pambuyo pa kudya kwambiri kwa 2 h, masiku atatu pa sabata kuyambira tsiku lobadwa kumene (PND) 29, mphamvu zowonjezera za EtOH zinayesedwa ndi EtOH self-administration (SA), malo okonda malo (CPP) ndi njira yolimbikitsira ethanol locomotor mwa achikulire mbewa. Nyama zomwe zili mu gulu lamafuta kwambiri (HFB) zomwe zimayendetsedwa ndi EtOH SA zimapereka kugwiritsidwa ntchito kwakukulu kwa EtOH ndikulimbikitsidwa kwambiri kupeza mankhwalawa. Mbewa za HFB zinapangitsanso kukonda chipinda chophatikizika mu CPP chokhala ndi gawo lochepa la EtOH. Kudziyimira pawokha pazakudya, mbewa zimayambitsa kutulutsa mphamvu kwa EtOH. Pambuyo pa njira ya SA, mbewa za HFB zidawonetsa kuchepa kwa mu opioid receptor (MOr) ndikuwonjezera kuchuluka kwa majeremusi a 1 receptor (CB1r) mu nucleus accumbens (N Acc), ndikuchepetsa kwa majini a tyrosine hydroxylase (TH) mu ventral dera lamatsenga (VTA). Kuphatikiza pamodzi zotsatira zake zikusonyeza kuti kudya kwambiri mafuta kungayimire chiopsezo pakukula kwa kumwa kwa EtOH.