Wopanda Chitetezo cha N-methyl-D-Aspartate Memantine Amachepetsa Kudya Binge-Monga Kudya, Kufunafuna Chakudya ndi Kudya Kwambiri: Udindo wa Nucleus Accumbens Shell (2014)

Matenda osokoneza bongo amadziwika ndi kudya mopitirira muyeso, kosalamulirika kwa chakudya chokoma mkati mwa nthawi yochepa. Udindo wa glutamatergic NMDA receptor system pakudya kwa hedonic sikumveka bwino. Cholinga cha phunziroli chinali kuwonetsa zovuta za N-methyl-D-aspartate (NMDA) yolandila wotsutsana nayo pamachitidwe okoma okhudzana ndi chakudya pogwiritsa ntchito makoswe omwe amatsanzira zomwe zimawoneka pakudya mopitirira muyeso. Pachifukwa ichi, timalola makoswe amphongo a Wistar kuti ayankhe kupeza chakudya chokoma, chotsekemera (Gulu losavuta) kapena chakudya chokhazikika cha chow (Gulu lowongolera), kwa tsiku la 1 ha, pansi pakulimbitsa kwa 1 (FR1) dongosolo lolimbikitsira . Takhazikika poyankha chakudya, tinayesa zotsatira za memantine pazakudya zamagulu a Chow ndi Zosangalatsa. Kenako, tinayesa zotsatira za memantine pakufunafuna chakudya, pansi pa dongosolo lachiwiri lolimbikitsira. Kuphatikiza apo, tidasanthula zomwe memantine amadya pakudya pomwe zimaperekedwa mosavutikira, kowala pang'ono pamayeso amdima / amdima. Pomaliza, tinayesa zotsatira za memantine pa kuyankha kwa FR1 pachakudya, pomwe ma microinfus adalowa mu nkhono la nucleus accumbens (NAcc) kapena pachimake. Kudalira kwa Memantine kumachepetsa kuchepa ngati kudya komanso kutsekereza kakhalidwe kofunafuna chakudya ndi kudya mopitilira muyeso, mosankha pagulu labwino. Mankhwalawa sanakhudze magwiridwe antchito gulu la Chow. Pomaliza, chipolopolo cha intra-NAcc, koma osati chapakati, kuchepa kwa memantine kumachepetsa kudya ngati kudya. Zonsezi, zikusonyeza kuti memantine ndi njira yothandizirayi ya mankhwala osokoneza bongo. Neuropsychopharmacology idavomereza kuwunikira koyambira pa intaneti, 10 Novembala 2014. doi: 10.1038 / npp.2014.299.