Chosankha cha dopamine D₄ receptors poyendetsa nthawi ya malipiro mu makina opanga ntchito (2014)

MALANGIZO:

Zolakwika zazidziwitso zokhudzana ndi zotsatira za kutchova juga zimapereka chiopsezo ku njuga zamatenda. Pogwiritsa ntchito makina olowetsa makina (rSMT), tawonetsa kale kuti kusasinthika kwa D₂ agonist quinpirole kumalimbikitsa chiyembekezo cholakwika cha mphothozo pakuyesa koyandikira, ndikuwonetsa gawo lofunikira kwambiri kwa banja la D₂ receptor pakuwongolera zotsatira zaposachedwa. Kudziwa mtundu wanji wa receptor subtype kungapangitse chitukuko cha chithandizo chamankhwala chovutikira makina.

ZITSANZO:

Makoswe makumi atatu mphambu awiri aamuna a Evans adaphunzira rSMT. Magetsi atatu amatha kuwayatsa kapena kuzimitsa. Kupambana kunasainidwa ngati magetsi onse atatu akanayikidwamo, pomwe kuyatsa kulikonse kumawonetsa kutayika. Makoswe ndiye adasankha pakati poyankha pa lever yosonkhanitsa, yomwe idapereka ma pellets a shuga a 10 pamayeso opambana koma 10-yachiwiri chilango pamayesero otayika, kapena kuyambitsa kuyesa kwatsopano m'malo mwake. Kuchita kunayesedwa potsatira kutsata kwadongosolo kwa kusankha kwa D₂, D₃, ndi D₄ receptor ligands.

ZOKHUDZA:

Wotsutsana ndi D₂ wotsutsa L-741,626, wotsutsana ndi D₃ SB-277011-A, ndi D₃ agonist PD128,907 sizinachitike. Mosiyana ndi izi, kusankha kwa D₄ agonist PD168077 pang'ono kunatsanzira zotsatira za quinpirole, kukulitsa mayankho olakwika pamayeso omwe sanapambane, pomwe wotsutsana ndi D₄ L-745,870 adakulitsa zolakwika. L-745,870 analinso mdani yekhayo amene angathetse mavuto obwera chifukwa cha quinpirole.

MAFUNSO:

Dopamine D₄ receptor imakhudzidwa mozama pakuwonetsa kuyembekezera kulandira mphoto mu rSMT. Kuthekera kwa L-745,870 kuchepetsa kugawa kwa zotayika monga phindu likuwonetsa kuti othandizira a D₄ akhoza kukhala othandiza pochita masewera olimbitsa makina ovuta.

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