Dopamine kumasulidwa mu ventral striatum ku Iowa Kutchova Njuga kumachitika ndi chisangalalo chowonjezereka m'magulu otchova njuga (2011)

ZOYENERA:

Kukondwerera kutchova juga kumayesedwa kuti kumagwirizanitsidwa ndi njira zothandizira kubereka njuga. Apa, tidayesa lingaliro loti kutulutsidwa kwa dopamine kukhudzana ndi kuchuluka kwa chisangalalo mu Pathological Gambler poyerekeza ndi Healthr Controls.

Kupanga:

Pathological Gambler and Healthy Controls anayesedwa poyeserera munthawi yopanda njuga (poyambira) ndi chikhalidwe cha njuga.

MALANGIZO:

Tidagwiritsa ntchito Positron Emission Tomography (PET) yokhala ndi tracer raclopride kuyeza kupezeka kwa dopamine D 2 / 3 receptor kupezeka mu ventral striatum panthawi yopanda njuga ndi kutchova juga kwa Iowa Maseweredwe a Matigari (IGT). Pambuyo pa mkhalidwe uliwonse omwe ophunzira akutenga gawo lawo anali osangalala.

SETTING:

Kuyesa kwelebhu.

ACHINYAMATA:

Masewera a 18 Pathological Guller ndi 16 Healthy Controls.

ZOKUTHANDIZA:

Othamanga a Pathological omwe amatulutsidwa ndi dopamine mu ventral striatum anali ndi magawo achisangalalo kwambiri kuposa Okhala Ndi Moyo wathanzi ngakhale kuti IGT yaying'ono. Palibe kusiyana pamlingo wachisangalalo ndi magwiridwe a IGT omwe adapezeka pakati pa Pathological Gambler ndi Healthy Controls popanda kutulutsidwa kwa dopamine. Pathological Gambler adawonetsa kulumikizana kwakukulu pakati pa kutulutsidwa kwa dopamine ndi gawo lokondwerera, pomwe palibe kuyanjana kotere komwe kunapezeka mu Healthy Controls.

MAFUNSO:

M'magulu otchova njuga dopamine kumasulidwa mu ventral striatum kumawoneka kuti kumalumikizidwa ndi kuchuluka kwachisangalalo ngakhale kuli kotsika kwa IGT. Zotsatirazo zitha kutanthauza kuti 'kuchepa kawiri' kwa dopamine mu njuga zamatenda, komwe kutulutsidwa kwa dopamine kumalimbikitsa kutchova juga koyipa kudzera kukulira kwachisangalalo, kuchepetsa zoletsa zosankha zowopsa, kapena kuphatikiza zonse ziwiri. Zotsatira izi zitha kukhala ndi tanthauzo pakumvetsetsa kwa dopamine mu njuga zamatenda ndi mitundu ina ya zizolowezi.

© 2010 Alembi, Zowonjezera © 2010 Society for the Study of Addiction.