Chiwerewere. 2016 Jan 15. doi: 10.1111 / adb.12368.
Zois E1, Kiefer F1, Lemenager T1, Vollstädt-Klein S1, Mann K1, Fauth-Bühler M1.
Kudalirika
Neuroimaging mu pathological njuga (PG) imalola kuphunzira kupangika kwa ubongo osadalira pamankhwala am'magazi / a neurotoxic omwe amachitika chifukwa chomwa mankhwala osokoneza bongo. Chifukwa cha comorbidity yapamwamba ya PG yokhala ndi vuto la kugwiritsa ntchito zinthu (SUD), zotsatira zoyambirira pazakapangidwe mu PG ndizotsutsana. Kufufuza kwaposachedwa ndikoyamba kuyang'ana kusintha kwa zinthu za imvi (GM) mu PG kuwongolera momwe zimakhudzira SUD poyerekeza omwe si comorbid (PG)OYERA ) ndi awiri a comorbid (PGALOHOL ndi PGPOLI ) magulu.
Anthu mazana awiri ndi asanu adaphatikizidwa pakuwonetsa: Odwala a 107 omwe adapezeka ndi PG ndi 98 maulamuliro athanzi (HCs). Tidagwiritsa ntchito morphometry yochokera ku voxel kuyang'ana kusiyana kwa kuchuluka kwa GM pakati pamagulu omwe amalamulira zaka, kusuta komanso kukhumudwa.
GM imatsika mu cortex yapamwamba ya medial ndi orbital frontal imachitika popanda kugwiritsa ntchito mankhwala mu PGOYERA poyerekeza ndi HCs. Njira yakutsogolo ya kuchepa kwa GM inali yofanana ndi PGALOHOL gulu pomwe kuphatikiza GM voliyumu idachepetsedwa mu anterior cingate koma idakulira mu amygdala.
Komanso, zigawo mu PGALCOHOL + POLI ndi kuchepetsedwa kwa voliyumu ya GM inali zam'mphepete zamankhwala, anterior cingulate ndi occipital lobe. PGALCOHOL + POLI sanawonetse zochepa zowonongeka poyerekeza ndi ma HC komanso zokhudzana ndi PGOYERA mu gwirisi ya posachedwa ndi yapakati. Tidawonetsa chinyengo chamtsogolo cha cortex GM ku PG popanda ma SUD comorbidities. Pomwe zigawo zina zomwe zanenedwapo kale kafukufukuyu zitha chifukwa chogwiritsa ntchito mankhwala ozunguza bongo, zikuwoneka kuti pali gawo limodzi lazosintha zomwe zimayenderana ndi chizolowezi chomachita juga.
MAFUNSO:
chizolowezi chamakhalidwe; imvi; magonedwe amatsenga; njuga zamatenda; ntchito mankhwala
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