Chiwerewere. 2015 Mar 29. onetsani: 10.1111 / adb.12242.
Contreras-Rodríguez O1, Albein-Urios N, Vilar-López R, Perales JC, Martínez-Gonzalez JM, Fernández-Serrano MJ, Lozano-Rojas O, Clark L, Verdejo-García A.
Kudalirika
Ma Neom biomarker pazovuta zomwe zimapangitsa kuti cocaine idalire (CD) akuchepa. Kufanizira kwachindunji kwa kulumikizidwa kwa ubongo mu maukonde omwe amayang'aniridwa ndi cocaine pakati pa CD ndikulowerera pamakhalidwe (mwachitsanzo, njuga zam'magazi, PG) zitha kukhala zothandiza. Kafukufukuyu adasiyanitsa ma network opumula omwe amagwira ntchito ogwiritsa ntchito a 20 omwe ali ndi CD, anthu a 19 omwe ali ndi PG ndi 21 anthu athanzi (zowongolera). Magulu owerengera adayesedwa kuti athe kuthana ndi misala yokhudzana ndi zamisala (kupatula kumwa mowa mwauchidakwa komanso kudalira kwa chikonga) komanso kugwiritsa ntchito mankhwala pakadali pano kapena njuga (kupatula PG). Poyamba tidasanthula mayanjano olumikizana padziko lonse lapansi mu corticolimbic mphhatso yolumikizana kenako ndikugwiritsa ntchito kusanthula kwa mbewu kuti tiwone kulumikizana kwa zigawo zomwe zikuwonetsa kusiyana pakati pa gulu. Tidasanthula maubwenzi apakati pa kulumikizidwa kochokera mu nthanga ndi kutsika kwa chidwi ndi kuuma kwa cocaine. CD poyerekeza ndi PG yowonetsedwa ikuwonjezera kulumikizana konse kwachilengedwe mu njira yayikulu yolumikizira corticostriatal network yokhudzana ndi orbitofrontal cortex, caudate, thalamus ndi amygdala. Kafukufuku wopangidwa kuchokera kumbewu adawonetsa kuti CD poyerekeza ndi PG yowonetsedwa yolumikizana pakati pa orbitof mbeleal and cgenates cortates cortices komanso pakati pa caudate ndi lateral preortal cortex, omwe akukhudzidwa ndikuyimira kufunikira kwa mayankho pakupanga zisankho. CD ndi PG poyerekeza ndi zowongolera zinawonetsa kusintha kosinthika kolumikizana pakati pa orbitof mbeleal ndi dorsomedial pre mbeleal cortices komanso pakati pa amygdala ndi insula, omwe akuphatikizidwa pakuphunzitsani zotsatira. Orbitofrontal-subgenual cingate cortical cholumikizira cholumikizidwa ndi impulsivity ndi caudate / amygdala cholumikizira chikugwirizana ndi zovuta za cocaine. Timalingalira kuti CD imalumikizidwa ndi kulumikizidwa kolumikizidwa mu netiweki yayikulu kwambiri ya ventral corticostriatal-amygdala yomwe ili yofunikira pakupanga chisankho ndikuwonetsa kuwonongeka kwakumwa kwa cocaine.
© 2015 Society for Study of Addiction.
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