Asayansi amachepetsa zizolowezi zomwe zimakhudzana ndi zovuta kutchova juga m'makola
By Cholengeza munkhani, | Science | 0 Comments
Mothandizidwa ndi kasitomala wa makoswe, ofufuza zaubongo ku University of Briteni anachepetsa machitidwe omwe ali ndi makoswe omwe amakonda kuphatikizana ndi kutchova njuga mwa anthu.
Kafukufukuyu, yemwe ali ndi njira yoyamba yopambana yojambulira makina olowera ndi makoswe ku North America, ndiye woyamba kuwonetsa kuti zovuta zamtundu wa juga zitha kuthandizidwa ndimankhwala omwe amaletsa ma dopamine D4 receptors. Zomwe zapeza zapezeka mu Psychiatry magazini.
"Pakufunika ntchito yambiri, koma zomwe apezazi zimapereka chiyembekezo chatsopano chamankhwala omwe amayamba kutchova juga, zomwe zikuwadetsa nkhawa anthu ambiri," atero a Paul Cocker, wolemba kafukufukuyu komanso wophunzira wa PhD ku UBC's Dept. of Psychology. "Kafukufukuyu akuwunikiranso njira zina zatsopano zamaubongo zomwe zimatengera njuga ndi chizolowezi cha juga."
Phunziroli, makoswe amatchova juga pamatumba a shuga pogwiritsa ntchito makina ogwiritsa ntchito omwe ali ndi nyali zitatu zowala ndi zopindika ziwiri zomwe amatha kuzikoka ndi ma paw. Makoswe akuwonetsa zinthu zingapo zomwe zimakhudzana ndi kutchova njuga zamavuto monga chizolowezi chogwiritsa "zoyipa zapafupi" zofanana ndi zomwe zapambana.
Kumanga pazofufuza zam'mbuyomu, gululi linayang'ana kwambiri ku dopamine D4 receptor, yomwe yalumikizidwa ndi zovuta zingapo zamakhalidwe, koma sizinatsimikiziridwe zothandiza popereka chithandizo. Kafukufukuyu adapeza kuti makoswe omwe amathandizidwa ndi dopamine D4 receptor-blocking blocking yowonetsedwa amachepetsa miyezo yokhudzana ndi zovuta njuga.
Ngakhale zomwe apeza zikutsimikizira kuti kutseka D4 dopamine receptor kungathandize kuchepetsa machitidwe otchovera njuga kwa anthu, ofufuzawo adziwe kuti kafukufuku wowonjezereka amafunika mankhwala asanaganize kuti ndi njira yothandiza yopangira mankhwala osokoneza bongo.
MALANGIZO
"Kutchova juga kwachikhalidwe kumawonekera kwambiri ngati chizolowezi chofanana ndi mankhwala osokoneza bongo kapena mowa, koma tikudziwa zochepa momwe tingapewere njuga," akutero a Cocker. "Kafukufuku wathu ndi woyamba kuwonetsa kuti poletsa ma receptor awa titha kuchepetsa zinthu zabwino zomwe zikubwera posachedwa zomwe zikuwoneka kuti ndizofunikira kutchova juga."
Njira: Mu kafukufuku wa mwezi wa 16, makoswe a 32 a labotale adayankhidwa pamiyeso itatu yoyambirira asanasankhe pakati paopinga awiri. Kuphatikiza kumodzi kwa nyali (nyali zonse zimawunikira) zimayimira win ndikuphatikiza zisanu ndi ziwiri (ziro, nyali imodzi kapena ziwiri) zimayimira kutayika. Wopanda ndalama yemwe amatulutsa ndalama adapereka mphothoyo ndi ma 10 pellets popambana mayesedwe, koma adapereka chindapusa cha "XTUMX-pili" pakutha pa mayendedwe. Woponya "roll also" adalola makoswe kuti ayambe kuyesa kwatsopano popanda kulipira, koma sanapatse shuga.
Chosangalatsa ndichakuti makoswe adawonetsa kusankha ndalamayo ikadzayatsa ndalama pamene magetsi awiri (pafupi ndi miss) amawunikira, ndikuwonetsa kuti makoswe, monga anthu, atenga nawo gawo posachedwa. Mwaletsa ma receptors a D4 ndi mankhwala, ofufuzawo adatha kuchepetsa kusankha kwa wopanga ndalama “wopanda ndalama” pamayeso omwe sanapambane.
Mankhwala otsekemera a D4 omwe amagwiritsidwa ntchito phunziroli adayesedwa kale pa anthu poyesa kuthana ndi zovuta zamtunduwu ngati schizophrenia koma amawoneka ngati alibe phindu.
Zophonya pafupi: Kukonda kwodziwika kotereku kumawerengedwa kuti ndi gawo lofunikira pakukonzekera mavuto amtundu wa njuga. Zakuti makina opanga amakonda kukhala ndi kuchuluka kwambiri kwa zoperewera pang'ono poyerekeza ndi masewera ena otchova juga mwina chifukwa chomwe makina olowera ali mtundu wotere wa kutchova juga.
Olemba zophunzira: Paul Cocker ndi Prof. Catharine Winstanley (UBC Dept. of Psychology), Bernard Le Foll (University of Toronto, Center for Addiction and Mental Health) ndi Robert D. Rogers (Bangor University). Phunziroli, A Selection Role for Dopamine D4 Receptors in Modulating Reward Expectancy in a Rodent Slot Machine Task, likupezeka mukapempha.
UBC's Laborator of Molecular and Behavioral Neuroscience, lotsogozedwa ndi Psychology Prof Catharine Winstanley, ikuyang'ana kwambiri kumvetsetsa njira zachilengedwe zogwirira ntchito monga kuwongolera chisangalalo ndi kutchova njuga, zomwe zimayambitsa njira zatsopano komanso zaposachedwa zochiritsira zovuta monga chidwi kuchepa kwa vuto la kusokonekera, chisokonezo cha kupuma, kusokonezeka kwa umunthu , komanso kugwiritsa ntchito mankhwala osokoneza bongo.
Vuto lotchova njuga: Kutchova juga kovutikira kumakhudza anthu atatu ndi asanu mwa anthu 100 alionse a ku North America, malinga ndi ziwerengero zaposachedwa.
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