Neuropsychopharmacology. 2019 Oct 9. yesani: 10.1038 / s41386-019-0534-1.
Limbrick-Oldfield EH1,2, Mati ine3,4, Azilonda RE5,3, Flechais RSA3, Mpukutu S3, Lingford-Hughes A3, Bowden-Jones H6, Clark L7,8.
Kudalirika
Zizindikiro zamaganizidwe amisala ndi ma neurobiological mwa anthu omwe ali ndi vuto la kutchova njuga (GD) zitha kuwonetsa chiopsezo cha transdiagnostic ku chizolowezi kapena zotsatira zoyipa za juga. Kugwiritsa ntchito njira yodziwitsa anthu omwe ali pachiwopsezo, tinayesa abale achiwopsezo ndi GD. Omwe amatenga nawo gawo omwe akufuna chithandizo cha GD (n = 20) adayerekezedwa ndi gulu loyang'anira amuna (n = 18). Achibale azachilengedwe a milandu ya GD (n = 17, yosalumikizidwa ndi gulu la GD lapano) anayerekezedwa ndi gulu lolamulira (n = 19) lomwe lidapitilira pang'ono ndi gulu lolamulira la GD. Ophatikizira adamaliza kuwunika kokwanira kwamisamba yazachipatala, magwiridwe antchito, ndi fMRI ya mphotho yosayembekezeka yazachuma. Gulu la GD linawonetsa kudzikweza komanso kudzitsitsa kuchotsera, ndikuchulukitsa chiwopsezo pa Ntchito ya Cambridge Gamble. Sitinayang'ane kuthamangitsidwa kwa galimoto pa ntchito yoyimitsa anthu. Achibale a GD adawonetsa zina; ie, kukwezedwa pamwamba (kusachita changu) ndikuwonjezera chiwopsezo pa Ntchito ya Gamble ya Cambridge. Sitinawone kusiyana kulikonse pakuyankha kwa neural pazotsatira zopambana, kaya mwa kusanthula kwa GD kapena abale poyerekeza ndi gulu lawolo. Pakati pagulu la GD, zochitika mu thalamus ndi caudate zimagwirizanitsidwa molakwika ndi zovuta zamtundu wa juga. Kuchulukirachulukira komanso kutenga chiwopsezo mu GD kulipo mwa achibale a milandu ndi GD, ndikuwonetsa kuti zolembazi zitha kuyimira kuwonongeka kwa GD.
PMID: 31597159
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