Neural substrates ya cue reactivity ndi kukhumba kutchova njuga (2016)

Tanthauzirani Psychiatry. 2017 Jan 3; 7 (1): e992. doi: 10.1038 / tp.2016.256.

Limbrick-Oldfield EH1,2, Mati ine3, Azilonda RE2,3, McGonigle J3, Sharman SP2,4, Goldstone AP3,5, Amakonda PR3,6, Waldman A7, Erritzoe D3, Bowden-Jones H8, Nutt D3, Lingford-Hughes A3,5,8, Clark L1,2.

Kudalirika

Kuphatikizika kwa cue ndi njira yokhazikitsidwa pakufufuza kowonjezera pakuyang'ana momwe ziliri ndi zomwe zimachitika pakukonzekera. Kuyesera uku kunayesa kuyankha mayankho okhudzana ndi ubongo pokhudzana ndi vuto la kutchova juga pogwiritsa ntchito zilonda zolumikizana molumikizana ndi zolakalaka zam'mano, komanso kuyerekezera ndi zokopa zomwe sizili njuga. Ochita nawo omwe ali ndi vuto la kutchova njuga (n = 19) opita ku chithandizo ndi kuwongolera kwa 19 adaziwona okha magawo a machitidwe okhudzana ndi kutchova juga, komanso malingaliro osaloŵerera m'zandale komanso zithunzi zokonda kwambiri (chakudya) panthawi ya maginito ogwiritsira ntchito maginito a (resMance imaging ~ fNRIX- 2 h atatha kudya mwachizolowezi. kuwunikira kwa fMRI kunayesa zochitika za ubongo zokhudzana ndi cue, kusintha komwe kukugwirizana ndi mgwirizano ndi mayanjano omwe amakhala ndi block-block-block blocking. Kukonda miyezo mwa omwe ali ndi vuto la kutchova njuga kumawonjezeka kutsatira njira za njuga poyerekeza ndi zomwe sizili njuga. Kupenda kwa fMRI kwawonetsa kusiyana kwa magulu amisala yakumanzere ndi kakhola kanyumba, ndi gulu la njuga lomwe likuwonetsa kuyambiranso kwa njuga, koma kusiyana pamalingaliro azakudya. Ochita nawo omwe ali ndi vuto la kutchova juga, akufunitsitsa kutchova njuga yolumikizidwa bwino ndi zochitika zokhudzana ndi kutchova njerewere pakati panjira ndi panjira yodutsa, komanso mosagwirizana ndi magwiridwe antchito pakati pa ventral striatum ndi medial pre mbeleal cortex. Masewera otchova njuga, koma osagwiritsa ntchito zakudya, amalimbikitsa mayankho mu ubongo pamagetsi okhudzana ndi mphotho mwa anthu omwe ali ndi vuto la kutchova njuga (poyerekeza ndi zowongolera), kupereka chithandiziro pakulimbikitsa kukopa chidwi. Zochita mu insula zimaphatikizidwa ndizolakalaka kwambiri, ndipo zingakhale cholimbana ndi kulowererapo.

PMID: 28045460

DOI: 10.1038 / tp.2016.256