Front Behav Neurosci. 2013; 7: 147.
Kuzindikira kumathandiza kwambiri pamakhalidwe osokoneza. Izi zitha kukhala choncho makamaka kwa “zizolowezi zakakhalidwe,” monga kutchova juga kwa njira, komwe kulimbikitsidwa kumachokera ku zochitika zachilengedwe zomwe phindu lake, makamaka, limaphunzira. Kafukufuku amene Porchet ndi anzawo amagwira amawunika ma dopamine ndi ma opioid am'manja potsatira ntchito zomwe zimapangitsa kuti anthu azisangalala ndi kutchova juga.
Ofufuzawo akuti dopamine D2 receptor antagonist, haloperidol idasokoneza kwenikweni mayankho okhudzana ndi zomwe zaposachedwa (zotsatira zomwe zimagwirizana kwambiri) koma zimawonjezera pang'ono kuyankha kwakuthupi kuzinthu izi.
Mosiyana ndi izi, wogwirizira wa opioid receptor antagonist, naltrexone adakulitsa kukhudzanso kwachilengedwe kwa zokondweretsazi komanso adakulitsa chidaliro cha kulosera zotsatira zamtsogolo kutsatira kuwina pamasewera opambana.
Zotsatira za haloperidol ndizogwirizana ndi kuwonjezereka kwa kuyendetsa thupi komanso kusowa kwa zotsatira zoyipa za mankhwalawa poyankha masewera a njuga omwe adawoneka kale mwa anthu athanzi.
Zotsatira za naltrexone ndizosagwirizana, chifukwa chakuti naltrexone ndi opioid antagonist nalmefene atsimikizira ogwira mtima poletsa kukakamiza kutchova juga kwa opanga njuga. Ngakhale sizinanenedwe kwathunthu, zotsatira zake zimatsimikizira kuti, ngati mankhwala osokoneza bongo, njuga imachita machitidwe a dopamine komanso opioid. Pamodzi ndi umboni wina, amanenanso mosapita m'mbali kuti otchova juga amatha kuyankha mosiyanasiyana akamagwiritsa ntchito mankhwala osokoneza bongo kuposa omwe amatchova njuga chifukwa chosiyana mu ubongo wa anthu awiriwa.
Pomwe zotsatira za zosangalatsambler ikuwonetsa kusokonekera kochokera mu ntchito zapakhomo, kuwonjezeka kwa chiwindi cha dopamine choyambitsidwa ndi haloperidol ndi kuwonjezeka kwa axis yovutikira yomwe ikuyambitsidwa ndi naltrexone ikhoza kuchita kubwezeretsa kapena kuchepetsa zolakwika zokhudzana ndi ubongo wabwinobwino womwe umayimira njira yatsopano ya ubongo kapena "yofikira" ubongo wamunthu wotchova njuga. Kubwereza kuyesayesa kumeneku kwa otchova njuga kungakhale kothandiza phunziroli.
;