Psychopharmacology (Berl). 2016 Jul 14.
Cocker PJ1, Lin INE2, Barrus MM2, Le Foll B3,4,5,6,7,8, Winstanley CA9.
Kudalirika
RATIONALE:
Makoswe, monga anthu, amatha kutengeka ndi zotsatira zolimbikitsidwa zokhudzana ndi mphotho zomwe zimaperekedwa mkati mwa zida zophatikizira, zomwe zimayambitsa chidwi kwambiri ndi zomwe zimadziwika kuti zakusowa. Tawonetsa kale kugwiritsa ntchito makina a makina (rSMT) kuti chiyembekezo chodzalandira mphotho izi zimapangitsa kuti dopamine D izikhala yolumikizidwa kwambiri ndi dopamine D4 cholandirira. D4 ma receptors amakhala makamaka m'malo oyambilira omwe amakonzedwa pamakina osewerera mwa anthu, monga insort cortex. Posachedwa insulayi idakopa chidwi chambiri chifukwa zikuwoneka kuti zikuchita gawo lalikulu pazinthu zomwe zimakonda komanso zikhalidwe. Komabe, insula ndi malo opatsa chidwi, ndipo zopereka zogonjera kuzikhalidwe zowonjezera sizikudziwika.
ZITSANZO:
Makoswe a Male Long Evans adaphunzitsidwa kuchita rSMT, kenako cannula yolowera mbali imodzi kapena yolumikizira inzake idayikidwa. Zotsatira za kusayang'anira ndikuyendetsa kwapaderaka a D4 agonist anafufuzidwa.
ZOKHUDZA:
Kuwonongeka kwakanthawi kwamakonzedwe, koma osati makulidwe a granular omwe ali ndi vuto pa RSMT. Mosiyana ndi izi, kulowetsedwa kwanuko kwa D4 agonist PD168077 kulowa m'chipululu cha agranular sizinakhudze magwiridwe antchito, koma atayikidwa m'chipinda cha granular, zidapangitsa kuti nyama zizitha kusiyanitsa kupambana pamayesero omwe sanapambane. Malo okhala agranular amatha kusintha zisankho pakakhala zotsutsana zomwe zilipo, mwina chifukwa chazomwe zimapangitsa kuti pakhale malingaliro ogwirizana potengera zikwangwani zakunja ndi zakunja, pomwe ma granular insular siofunikira pantchitoyi. Komabe, D4 zolandilira mkati mwa granular insula zitha kukulitsa chidwi chotsalira cha zoyipa zachilengedwe.
ZOKAMBIRANA:
Izi zimapereka chidziwitso pakuwongolera komwe kumayambitsa mphotho yoyipa pakubwera kwa juga komanso kupereka umboni wina kuti D4 ma receptor amaimira chandamale chopanga mankhwala opanga mankhwala a juga.
MAFUNSO:
Agranular insula; D4; Dopamine; Kutchova njuga; Phula lamkaka; Pafupifupi miss
PMID: 27417550
DOI: 10.1007/s00213-016-4355-1
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