Chiwerewere. 2016 Sep 9. doi: 10.1111 / adb.12447.
van Timmeren T1, Jansen JM2,3, Caan MW4, Goudriaan AE2,5, van Holst RJ2,6,7.
Kudalirika
Kutchova juga kwa Pathological (PG) ndichizolowezi chomwe chimadziwika chifukwa cholephera kusiya kutchova juga ngakhale zotsatirapo zoyipa, zomwe zingakhale pakati pazosowa. Zowonadi, kusasinthasintha kwazidziwitso komwe kumalumikizidwa ndi PG komanso kuchepetsa kukhulupirika kwa kulumikizana pazinthu zoyera pakati pa basal ganglia ndi preortalal cortex. Sizikudziwika, komabe, momwe zovuta zoyera zokhudzana ndi kukhudzika zimakhudzana ndi kusokonekera kwazidziwitso komwe kukuwoneka mu PG.
Tidagwiritsa ntchito chithunzi cha maginito ogwiritsira ntchito maginito pa maginito ogwiritsira ntchito maginito (ma PGs; n = 26) ndi kuwongolera wathanzi (HCs; n = 26). Kuchita kusinthasintha kwa kuzindikira kumayesedwa mwamakhalidwe molondola komanso nthawi yothandizira pakusintha, pomwe ntchito zaubongo zimayesedwa malinga ndi mayankho omwe amadalira okosijeni m'magazi. Tidagwiritsanso ntchito kuyerekezera kokhazikika pamtundu wa data (PGs = 21; HCs = 21) kuphatikiza ziwerengero zamatayala ozungulira ndi kuwunika kwa fiberabor kuyesa kuyera kwa nkhani yoyera pakati pa basal ganglia ndi dorsolateral prefrontal cortex.
Ngakhale panalibe kusiyana kwakukulu pamagulu onse pantchitoyo, ntchito zogwirizana ndi ma neural, kapena ziwonetsero zokhudzana ndi malo ochepa, ma PG adawonetsa kuchepa kwa kuyera kwa nkhani yoyera pakati pa basal ganglia ndi preortal cortex. Zotsatira zathu zimakwaniritsa ndikukulitsa zomwe zapezedwa kuchokera ku kafukufuku wakale m'madokotala omwe amadalira mowa.
Ngakhale sitinapeze kuyanjana pakati pa kukhulupirika kwa nkhani yoyera ndi kugwira ntchito pano, kuchepa kwa zinthu zoyera kungapangitse kuti kuchepa kwa ntchito yolumikizira ma network omwe akufunika pakuwongolera machitidwe mu PG. Chifukwa chake, zomwe tapeza zitha kuyambitsa vuto ku PG, ndipo tikuti zomwe zapezazi zingathe kupitilira pakulakwitsa.
MAFUNSO: Mankhwala osokoneza bongo; DTI; chizolowezi chamakhalidwe; kukakamizidwa; corticostriatal; kutchova njuga; fMRI
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