Clin Psychopharmacol Neurosci. 2017 Nov 30; 15 (4): 361-368. doi: 10.9758 / cpn.2017.15.4.361.
Nam B1, Bae S2, Kim SM3, Hong JS3, Han DH3.
Kudalirika
Cholinga:
Kafukufuku angapo adanenanso zakufunika kwa bupropion ndi escitalopram pakuchepetsa kusewera kwambiri kwa intaneti. Tidawerengera kuti onse bupropion ndi escitalopram atha kukhala othandiza kuchepetsa kuwonongeka kwa zizindikiro zosokoneza ndi zizindikiro za intaneti (IGD) mwa odwala omwe ali ndi vuto lalikulu la nkhawa komanso IGD. Komabe, kusintha kwa kulumikizidwa kwa ubongo pakati pa njira yokhazikika yothandizira ma network (DMN) ndi seviti yotsekera inali yosiyana pakati pa bupropion ndi escitalopram chifukwa cha ma pharmacodynamics awo osiyanasiyana.
Njira:
Kafukufukuyu adapangidwa ngati kuyeserera kawiri ka 12-sabata kawiri. Odwala makumi atatu adalembedwa kafukufukuyu (gulu la 15 lupropion + 15 escitalopram). Kuti tiwone kuyanjana kwamphamvu kosakanikirana (FC) pakati pa mahabule a DMN ndi network ya masisitere, tinasankha zigawo za 12 kuchokera pama pulogalamu odziwika okha a PPAA.
Results:
Pambuyo pa kugwiritsa ntchito mankhwala osokoneza bongo, zizindikiritso zomwe zidakhumudwitsa ndi zizindikiro za IGD m'magulu onse awiri zidasintha. Zovuta komanso chidwi ndi chidwi mu gulu la bupropion zidachepetsedwa kwambiri, poyerekeza ndi gulu la escitalopram. Pambuyo pa chithandizo, FC mkati mwa DMN yokha mu escitalopram inachepa pomwe FC pakati pa DMN ndi ma salience network mu bupropion gulu idatsika. Bupropion idalumikizidwa ndi FC yomwe idatsika kwambiri mkati mwa ma setievesi komanso pakati pa network ya salience ndi DMN, poyerekeza ndi escitalopram.
Kutsiliza:
Bupropion adawonetsa zotsatira zazikulu kuposa escitalopram pakuchepetsa kusakhudzika ndi chizindikiro cha chidwi. Kulumikizidwa kwa ubongo pakati pa ma netiweki otsekemera ndi DMN kumawoneka kuti kumalumikizidwa ndi mawonekedwe owonjezera a IGD komanso kusokonekera kwa odwala a MDD omwe ali ndi IGD.
MAFUNSO: Bupropion; Citalopram; Ntchito zamagetsi oyeserera. Intaneti; Chachikulu kukhumudwa chisokonezo; masewera akanema
PMID: 29073748
DOI: 10.9758 / cpn.2017.15.4.361
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