J Nerv Ment Dis. 2018 Aug;206(8):644-656. doi: 10.1097/NMD.0000000000000861.
Kalidiroli A1, Serati M, Buoli M.
Kudalirika
Cholinga chachikulu cha ndondomekoyi ndi kupereka ndondomeko yowonongeka kwa machitidwe okhudza ubongo wa HIV (IA), makamaka chifukwa chokwanira ndi kusiyana ndi matenda a bipolar (BPAD). Zomwe zili ndi zizindikiro za HIV / neurobiological za IA kapena zofanana / zosiyana ndi BPAD monga nkhani zazikulu, kuchokera ku 1990 kuti zilembedwe ndi kulembedwa m'Chingelezi, zinaphatikizidwa. Kusiyanitsa pakati pa IA ndi matenda ena opatsirana, kuphatikizapo BPAD, ndi wamba. Zovuta pa njira za dopaminergic zapezeka mu IA komanso mu matenda a maganizo. Zambiri zamaphunziro ku IA zimapereka chithandizo choipa cha hypodopaminergic chosagwira ntchito mugawo la mphotho ya ubongo komanso zopindulitsa kwambiri panthawi ya kukwera kwa maganizo. Kafukufuku wa Neuroimaging amasonyeza chisokonezo cha prefrontal cortex chosagwirizana pakati pa odwala ndi osokonezeka maganizo. BPAD ndi IA zimakhala zowonjezereka, monga ma poymomphisms mu zojambula za nicotinic, zomwe zimakhala zosaoneka bwino, serotonin / dopamine dysfunction, komanso kuchitapo kanthu kuti zikhale zolimba. Tsogolo ndikutanthauzira zofunikira zogonana kuti zifotokoze bwino ubale wa IA / BPAD.
PMID: 30028359
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