CNS Wopenya. 2019 Jun 4: 1-10. yesani: 10.1017 / S1092852919001019.
Ioannidis K1, Redden SA2, Valle S2, Chamberlain SR1, Perekani JE2.
Kudalirika
KUCHITA:
Ogwiritsa ntchito intaneti ovuta ali ndi vuto la kuwonongeka pamitundu yosiyanasiyana. Kafukufuku akuwonetsa kuti ma COMT haplotypes amakhala ndi zovuta pakuzindikira. Tinayesetsa kufufuza kusiyana pakati pa ma genetic a ogwiritsa ntchito intaneti ovuta komanso ngati izi zingatithandizire kudziwa kusiyanasiyana komwe kungachitike.
ZITSANZO:
Tinalemba 206 osalandira chithandizo kufunafuna anthu omwe ali ndi makhalidwe okhudzidwa ndipo adapeza chiwerengero cha anthu, matenda, komanso chidziwitso chodziwika bwino, komanso mauthenga achibadwa a COMT rs4680 ndi rs4818. Tinawadziwitsa otsogolera a 24 omwe anali ndi vuto la kugwiritsa ntchito intaneti (PIU) ndipo anayerekezera PIU ndi anthu omwe sanali a PIU pogwiritsa ntchito njira imodzi yochezera (ANOVA) ndi chikwama chayi ngati n'koyenera.
ZOKHUDZA:
PIU inagwirizanitsidwa ndi ntchito yoipitsitsa pa kupanga chisankho, kuwonetseratu mwamsanga, komanso ntchito za kukumbukira malo. Mitundu ya majini imakhudzidwa ndi kusinthika kwa chidziwitso, koma chiwerengero cha PIU sichinali chosiyana kwambiri ndi haplotypes ya COMT.
POMALIZA:
Phunziroli likuwonetsa kuti PIU imadziwika ndi zoperewera pakupanga zisankho ndikugwira ntchito zolembera; imaperekanso umboni wa mayankho okhudzidwa kwambiri komanso osadziwika bwino pakuzindikira ntchito, yomwe ili malo oyenera kuyang'anitsitsa ntchito zamtsogolo. Zotsatira zomwe zimapezeka mu machitidwe achidziwitso a ma PIU zimatanthauza kuti ziwalo zofunikira zenizeni za PIU sizingagwiritsidwe ntchito mwazimene zimakhudza kugwira ntchito kwa COMT ndi kugwirizanitsa ntchito; kapena kuti chiwalo cha mtundu wa PIU chimaphatikizapo mitundu yambiri ya mavitamini omwe amachititsa pang'ono chabe.
MAFUNSO: COMT; Kugwiritsa ntchito kovuta pa intaneti; kuzindikira; chibadwa; intaneti
PMID: 31159911
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