Kujambula m'maganizo kumasonyeza kusuta fodya kosatha kumakhudza ubongo wa ubongo
June 6th, 2011 mu sayansi ya sayansi
Umboni wotsimikizika wazovuta zakusuta chamba zomwe zawululidwa pa Msonkhano Wapachaka wa 58 wa SNM zitha kubweretsa mankhwala osokoneza bongo ndikuthandizira kafukufuku wina wokhudzana ndi ma cannabinoid receptors, dongosolo la ma neurotransication lomwe limalandira chidwi chachikulu. Asayansi amagwiritsa ntchito kulingalira kwama molekyulu kuti awonetse kusintha kwa ubongo wa omwe amasuta chamba motsutsana ndi omwe samasuta ndipo apeza kuti kugwiritsa ntchito mankhwala osokoneza bongo kumapangitsa kuchepa kwa ma cannabinoid CB1 receptors, omwe samangokhalira kusangalala, kudya komanso kulekerera zopweteka koma khamu zina zamaganizidwe ndi thupi lathu.
Jussi Hirvonen, MD, PhD, wolemba bukuli pakati pa National Institute of Mental Health ndi National Institute on Drug Abuse, a Bethesda, Md anati: "Kuledzera ndi vuto lalikulu lazachipatala komanso zachuma." kumvetsetsa njira zamaubongo zomwe zimakhudzana ndi kusuta. Ndi kafukufukuyu, tidakwanitsa kuwonetsa koyamba kuti anthu omwe amazunza nkhanza ali ndi zovuta zina zama cannabinoid receptors muubongo. Izi zitha kukhala zofunikira pakukhazikitsa njira zatsopano zochitira nkhanza anthu. Kuphatikiza apo, kafukufukuyu akuwonetsa kuti kuchepa kwa zolandilira mwa anthu omwe amagwiritsa ntchito mankhwala osokoneza bongo amabwerera mwakale akasiya kusuta mankhwalawo. ”
Malingana ndi National Institute on Drug Abuse, chamba ndi nambala yodziphwanya mankhwala osayenera mwa America. Mankhwala osokoneza bongo, omwe ndi mankhwala osokoneza bongo, ndi delta-9-tetrahydrocannabinol (THC), yomwe imagwirizanitsa ndi mapuloteni ambiri a ubongo mu ubongo ndi thupi lonse pamene akusuta kapena atsekedwa, akupanga wapamwamba kwambiri. Zokwanira za kannabinoid mu ubongo zimakhudza malingaliro ndi zochita zosiyanasiyana, kuphatikizapo zosangalatsa, kulingalira, kulingalira nthawi ndi kukumbukira, kulingalira zoganiza, ndi kugwirizana kwa kayendetsedwe kake. Pali palinso mankhwala obwera m'magazi m'thupi lonse lomwe limagwira ntchito zosiyanasiyana za m'mimba, m'mtima, kupuma ndi machitidwe ena a thupi. Pakalipano tizilombo toyambitsa matendawa timadziwika bwino, CB1 ndi CB2, omwe poyamba ankagwiritsidwa ntchito kwambiri m'katikati mwa mitsempha ya m'magazi komanso m'magwiridwe a chitetezo cha mthupi komanso m'maselo ofunika kwambiri.
Phunziroli, ofufuza adalemba anthu osuta fodya a 30 tsiku ndi tsiku omwe adayang'anitsitsa pa chipatala chakumapeto kwa milungu inayi. Nkhanizi zimagwiritsidwa ntchito pogwiritsa ntchito positron emission tomography (PET), yomwe imapereka zidziwitso zokhudzana ndi thupi la thupi. Zida zinajambulidwa ndi radioligand, 18F-FMPEP-d2, yomwe imagwiritsidwa ntchito ndi radioactive fluorine isotope ndi analog yotchedwa neurotransmitter yomwe imagwirizana ndi CB1 yolandira ubongo.
Zotsatira za phunziroli zikusonyeza kuti nambala ya receptor inachepa peresenti ya 20 mu ubongo wa anthu osuta fodya poyerekeza ndi zinthu zowononga bwino zomwe zimakhala zochepa poyerekeza ndi nthendayi nthawi yonse ya moyo wawo. Kusintha uku kunapezeka kuti kuli ndi mgwirizano ndi chiwerengero cha zaka zomwe zinkasuta. Mwa oyambirira oyambitsa fodya a 30, 14 ya nkhaniyi inayambanso kuyeza PET pambuyo pa mwezi umodzi wa kudziletsa. Panali kuwonjezeka kwakukulu kwa ntchito ya receptor m'madera omwe adachepetsedwa kumayambiriro kwa phunzirolo, zomwe zikusonyeza kuti ngakhale kusuta kwapachilombo koyambitsa matendawa kumayambitsa kusokoneza kwa mapulogalamu a CB1, kuwonongeka kumasinthidwa ndi kudziletsa.
Zomwe zinapezedwa kuchokera ku maphunzirowa ndi zamtsogolo zingathandize kafukufuku wina pofufuza ntchito ya kujambula PET ya CB1 receptors-osati chifukwa cha mankhwala osokoneza bongo, komanso matenda osiyanasiyana aumunthu, kuphatikizapo matenda opatsirana ndi khansa.
Zambiri: Scientific Paper 10: J. Hirvonen, R. Goodwin, C. Li1, G. Terry, S. Zoghbi, C Morse, V. Pike, N. Volkow, M. Huestis, R. Innis, National Institute of Mental Zaumoyo, Bethesda, MD; National Institute on Kugwiritsa Ntchito Mankhwala Osokoneza Bongo, Baltimore, MD; "Kusintha kosasunthika komanso kosasunthika kwakanthawi kwamaubongo a cannabinoid CB1 receptors mu osuta fodya tsiku lililonse," Msonkhano Wapachaka wa 58 wa SNM, Juni 4-8, 2011, San Antonio, TX.
Kuperekedwa ndi Society of Nuclear Medicine
Kujambula m'maganizo kumasonyeza kusuta fodya kosatha kumakhudza ubongo wa ubongo.
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