Premature and delayed ejaculation: two ends of a single continuum influenced by hormonal milieu. (2011)

Printer-friendly version

Comments: I wish we had the full study. This one says that for a correlation exist between high prolactin & high TSH and PE. Prolactin can inhibit dopamine and testosterone.

Int J Androl. 2011 Feb;34(1):41-8. doi: 10.1111/j.1365-2605.2010.01059.x.

Corona G, Jannini EA, Lotti F, Boddi V, De Vita G, Forti G, Lenzi A, Mannucci E, Maggi M.
Department of Clinical Physiopathology, Andrology Unit and Endocrinology, University of Florence, Florence, Italy.


Although it is well established that all the aspects of male reproduction are hormonally regulated, the endocrine control of the ejaculatory reflex is still not completely clarified. Sex steroids, thyroid and pituitary hormones (oxytocin and prolactin) have been proposed to control the ejaculatory process at various levels; however, only a few reports are currently available. The aim of this study was to evaluate the contribution of testosterone, thyrotropin (TSH) and prolactin (PRL) in the pathogenesis of ejaculatory dysfunction in a large series of subjects consulting for sexual dysfunction.

Among the 2652 patients studied, 674 (25.2%) and 194 (7.3%) reported premature and delayed ejaculation (PE and DE), respectively. Categorizing ejaculatory difficulties on an eight-point scale starting from severe PE and ending with anejaculation (0 = severe PE, 1 = moderate PE, 2 = mild PE, 3 = no difficulties, 4 = mild DE, 5 = moderate DE, 6 = severe DE and 7 = anejaculation), PRL as well as TSH levels progressively increased from patients with severe PE towards those with anejaculation. Conversely, the opposite was observed for testosterone levels. All of these associations were confirmed after adjustment for age (adjusted r = 0.050, 0.053 and -0.038 for PRL, TSH and testosterone, respectively; all p

© 2010 The Authors. International Journal of Andrology © 2010 European Academy of Andrology.