J Neurol Sci. 2011 Nov 15; 310 (1-2): 53-7. Epub 2011 Jul 23.
Moriyama TS, Felicio AC, Chagas MH, Tardelli VS, Ferraz HB, Tumas V, Amaro-Junior E, Andrade LA, Crippa JA, Bressan RA.
Sursă
Instituto do Cérebro, Institutul de Ensino și Pesquisa do Spitalul Israelita Albert Einstein, Sao Paulo, Brazilia. [e-mail protejat]
Abstract
Social Anxiety Disorder (SAD) is more common among PD patients than in the general population. This association may be explained by psychosocial mechanisms but it is also possible that neurobiological mechanism underlying PD can predispose to SAD.
Scopul acestui studiu a fost de a investiga un posibil mecanism dopaminergic implicat în pacienții PD cu DAU, prin corelarea potențialului de legare a transportorilor dopaminei striate (DAT-BP) cu intensitatea simptomelor de anxietate socială la pacienții cu PD using SPECT with TRODAT-1 as the radiopharmaceutical. Eleven PD patients with generalized SAD and 21 PD patients without SAD were included in this study; groups were matched for age, gender, disease duration and disease severity. SAD diagnosis was determined according to DSM IV criteria assessed with SCID-I and social anxiety symptom severity with the Brief Social Phobia Scale (BSPS). Demographic and clinical data were also collected.
DAT-BP was significantly correlated to scores on BSPS for right putamen (r=0.37, p=0.04), left putamen (r=0.43, p=0.02) and left caudate (r=0.39, p=0.03). No significant correlation was found for the right caudate (r=0.23, p=0.21). Această constatare poate întări ipoteza că disfuncția dopaminergică ar putea fi implicată în patogeneza anxietății sociale în PD.
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