e faʻaalia ai le eseesega o amioga faʻafeusuai: Faʻaleagaina o Gaoioiga Feusuaiga (2018)

Neuroscience. 2018 Nov 10; 396: 1-23. doi: 10.1016 / j.neuroscience.2018.11.002.

Sanna F1, Lautele L2, Serra MP2, Boi M2, Bratzu J3, Sanna F4, Corda MG4, Giorgi O4, Melis MR3, Argiolas A5, Quartu M6.

lē faʻatino

Male Roman High- (RHA) ma Low-Aloʻalo (RLA) isumu faʻaalia eseesega tele i feusuaʻiga (RHA rat faʻaalia maualuga feusuaʻiga faʻaosofia ma sili puleaina faʻataʻitaʻiga nai lo RLA isumu). O nei eseʻesega e matua aliali mai i feusuaʻiga naif o isumu (lea e faʻataʻitaʻi ma le fafine taliaina fafine mo le taimi muamua), ma o loʻo iai pea, e ui ina faʻaititia, i le maeʻa ai o faʻataʻitaʻiga e lima, pe a maua le poto masani i feusuaiga. Talu ai o gaioiga faʻafeusuaiga o se taui masani e faʻaosofia ai neural activation ma synaptic palasitika suiga i limbic faiʻai vaega, matou suʻesuʻeina pe o le eseesega i feusuaiga i le va o nei isumu laina eo mai ma suiga i le faʻaaliga o faʻailoga o neural activation ma palasitika, ie, c -Fos, ΔFosB (a truncated form of FosB), Brain-Derived Neurotrophic Factor (BDNF) ma lona tyrosine kinase receptor B (trkB) ma gaioiga faʻatonutonuina cytoskeleton-fesoʻotaʻi (Arc) porotini i le ventral tegmental eria (VTA), nucleus accumbens (Acb) (autu ma atigi) ma medial prefrontal cortex (mPFC) o feusuaiga le mama ma poto masani RHA ma RLA isumu e Western Blot ma / po o le immunohistochemistry. Lenei suʻesuʻega faʻaalia ai o nei faʻailoga na suia eseese i le VTA, Acb ma mPFC o RHA ma RLA iole, ina ua maeʻa gaioiga. I laina uma o le iole, o suiga na manino mai i isumu naif, na masani ona mouʻese i isumu poto masani ma na maualuga i le RHA nai lo RLA isumu. O nei sailiga faʻamaonia o feusuaʻiga gaioiga faʻamalosia neural activation i limbic faiʻai vaega e aofia ai i le faʻaosofia ma taui, e mafua ai suiga i le synaptic plasticity ma feusuaʻiga mauaina poto masani, ma faʻaalia ai o nei faʻamoemoeina i luga o manu 'genotypic / phenotypic uiga.

FUAFUAGA: BDNF / trkB; Vavega lata mai; Immunochemistry; tama RHA ma RLA; amioga tau feusuaiga; aafiaga tau feusuaiga

PMID: 30423358

FAIA: 10.1016 / j.neuroscience.2018.11.002