Neuroscience. 2018 Nov 10;396:1-23. doi: 10.1016/j.neuroscience.2018.11.002.
Sanna F1, Poddighe L2, Serra MP2, Boi M2, Bratzu J3, Sanna F4, Corda MG4, Giorgi O4, Melis MR3, Argiolas A5, Quartu M6.
lē faʻatino
Male Roman High- (RHA) ma Low-Avoidance (RLA) rats o loʻo faʻaalia ai le tele o eseesega i amioga faʻafeusuaiga (RHA rats e faʻaalia le maualuga o le faʻaosofiaina o feusuaiga ma sili atu le faʻatinoina o gaioiga nai lo RLA rats). O nei eseesega e matua iloga lava i iole e le fa'afeusuaiga (lea e fa'afeusua'i ma se tama'i iole talia mo le taimi muamua), ma o lo'o i ai pea, e ui ina fa'aitiitia, pe a mae'a su'ega fa'afeusuaiga e lima, pe a maua le fa'afeusuaiga. Talu ai o feusuaiga o se taui masani lea e faʻaosofia ai neural activation ma synaptic palasitika suiga i vaega o le faiʻai limbic, matou te suʻesuʻeina pe o le eseesega o feusuaiga i le va o nei laina iole o loʻo faʻatasi ma suiga i le faʻaaliga o faailoga o le faʻagaioiina o neural ma le palasitika, ie, c -Fos, ΔFosB (se fomu tipi o FosB), Brain-Derived Neurotrophic Factor (BDNF) ma lona tyrosine kinase receptor B (trkB) ma le Gaoioiga faʻatulafonoina cytoskeleton-fesoʻotaʻi (Arc) porotini i totonu o le ventral tegmental area (VTA), nucleus accumbens (Acb) (autu ma atigi) ma medial prefrontal cortex (mPFC) o fa'afeusuaiga fa'avalea ma le poto RHA ma RLA isumu e Western Blot ma / po'o immunohistochemistry. O lenei suʻesuʻega o loʻo faʻaalia ai o nei faʻailoga na suia eseese i le VTA, Acb ma le mPFC o RHA ma RLA rats, pe a maeʻa gaioiga faʻafeusuaiga. I laina e lua o isumu, o suiga na matua iloga lava i iole naive, e mou atu i iole poto ma maualuga atu i le RHA nai lo iole RLA. O nei suʻesuʻega e faʻamaonia ai o gaioiga faʻafeusuaiga e faʻaosoina ai neural activation i vaega o le faiʻai limbic e aʻafia i le faʻaosofia ma le taui, e oʻo atu ai i suiga i le synaptic plasticity ma le mauaina o faʻafeusuaiga, ma faʻaalia ai e faʻalagolago i uiga o le genotypic / phenotypic manu.
FUAFUAGA: BDNF/trkB; Genes vave vave; Immunochemistry; iole tane RHA ma RLA; amioga fa'afeusuaiga; aafiaga tau feusuaiga
PMID: 30423358
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