Meaʻai Meaʻai. 2019 Apr 17;10(4):1985-1998. doi: 10.1039/c8fo02118j.
Reichelt AC 1, Gibson GD , Abbott KN , Hare DJ .
lē faʻatino
Ole palasitika faiʻai ose faʻavae e tele lona faʻamoemoeina e faʻalagolago uma ile neurons ma extracellular matrix (ECM) fausaga, e aofia ai upega perineuronal (PNNs). I le medial prefrontal cortex (mPFC) PNN e masani ona siʻomia vave-spiking parvalbumin (PV) -o loʻo iai GABAergic interneurons ma e totonugalemu i tulafono faʻatonutonu o le neuroplasticity. I se faʻaopopoga i le atinaʻeina o gaʻo, o gaʻo maualuga ma suka maualuga (HFHS) o loʻo fesoʻotaʻi foʻi ma suiga i le faiʻai palasitika ma faʻalogona lagona i tagata. I le suʻesuʻeina o le aʻafiaga o PNN ma le palasitino i totonu o le mPFC i le taumafataga na faʻaosoina i amioga le lelei (i lenei tulaga faʻatauaina lautele), na matou faʻaalia tama talavou (aso fanau P28-P56) iole i se HFHS-faʻaopopo meaʻai. I P56 HFHS-fafagaina manu ma tausaga fetaui lelei faʻatagaina fafagaina masani chow na faʻamamaina ma faʻatasi-faʻatulagaina o PNNs ma PV neo i le prelimbic (PrL) ma infralimbic (IL) ma muamua cingulate (ACC) sub itulagi o le PFC na suʻesuʻeina e itulua fluorescence immunohistochemistry. ΔFosB faʻaaliga na iloiloina foi o se fuataga o le tumau gaioiga ma amioga faʻailoga vaisu. O le faʻaaogaina o meaʻai a le HFHS na faʻaititia ai le numera o le PV + neurons ma le PNN i totonu o le infralimbic (IL) itulagi o le mPFC i le -21.9% ma le -16.5%. E ui e leʻi faʻaititia le faʻaititia o faʻamaumauga ole neurons ma le PNL i le ACC poʻo le PrL, ae na faʻateleina le pasene o le PV + ma le PNN o loʻo faʻaalia i totonu o itulagi uma na suʻesuʻeina o le mPFC i HFHS-rat rat (+ 33.7% i le 41.3%) Ua faʻaalia ai o le faitau aofai o totoga o le neonio o loʻo totoe o na e faʻataʻamilomiloina e PNN, ia e ono gafatia se puipuiga mai le HFHS diet-induced mPFC-disregulation. ShowedFosB faʻaaliga faʻaalia ai le 5-10-lafu faʻateleina (p <0.001) i itulagi mPFC uma, lagolagoina le manatu faʻapea o le HFHS taumafataga faʻaosofia mPFC faʻaletonu ma mulimuli ane amio faʻaletonu. O faʻamatalaga na faʻaalia mai e faʻaalia ai le ono mafai ai ona faʻaaogaina le neurophysiological ma le tali atu i le paʻu o meaʻai na aʻafia ai tagata, ona o le maualuga o le mafaufau i le talavou.
PMID: 30900711
FAIA: 10.1039 / c8fo02118j
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