Cell Mol Neurobiol. 2008 Feb; 28 (2): 157-72. Epub 2007 Nov 28.
puna
Matagaluega o Neuropharmacology, National Institute on Drug Dependence, Peking University, 38, Xue Yuan Road, Hai Dian District, Beijing, 100083, Saina.
lē faʻatino
O vaisu o fualaau faasaina, e iloga i le maualuga o fua faatatau o le toe foi, ua iloa o se ituaiga o le neuroadaptive disorder. Talu ai o le extracellular signal-regulated kinase (ERK) ala e taua tele i le neuroplasticity i le faiʻai matutua, o le malamalama i le matafaioi o lenei auala e taua tele mo le malamalama i le mole mole faʻavae o vaisu ma toe faʻafoʻi.
O iinei, matou te iloiloina ai tusitusiga muamua e taulaʻi atu i aʻafiaga o le faʻaalia i cocaine, amphetamine, Delta (9) -tetrahydrocannabinol (THC), nicotine, morphine, ma le ava malosi i luga o le ERK faʻailoga i le mesocorticolimbic dopamine system; o nei suiga o le ERK faʻailoga ua manatu e saofagā i le faʻamalieina o fualaau faʻamaʻi ma le faʻaleagaina umi e mafua mai i le faʻaaogaina o fualaau faasaina.
Ona matou talanoaina lea o le alia'e i luga o le ala fa'ailoga ERK o lo'o fa'agaoioia e ala i le fa'aalia o vaila'au o le fa'aleagaina ma fa'ailoga o le si'osi'omaga na tu'ufa'atasia muamua ma vaila'au. Ma le mea mulimuli, matou te finau talu ai o le faʻamalosia o le ERK o se faiga mole mole autu i le toe faʻafoʻiina o mea e fiafia i ai ma le puleaina o fualaau faasaina, o le faʻaogaina o vailaʻau o le ERK auala o se togafiti togafitiga talafeagai mo vaisu.
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