puna
Polokalama Faʻauʻu i le Neuroscience / Inisitituti mo Saienisi Faʻasaienisi ma Tekinolosi, Iunivesite o Inje, Hanwha CC R & D Building, 6 Shinsung Dong, Yusung Gu, Daejun 305-345, Korea i Saute.
lē faʻatino
O le Dopamine ma le hormone testosterone o mea taua ia e faʻatonutonu ai amioga faʻafeusuaiga tane. Ina ia suʻesuʻeina le avanoa e fesoʻotaʻi faʻatasi nei mea e lua, na matou suʻesuʻeina le tulaga gafatia o le androgen receptor (AR) luga fa'aliliuga gaoioiga o le tyrosine hydroxylase (TH) gene e fa'ailogaina le enzyme fa'atapula'a fua o le ala o le biosynthesis dopamine. I lenei suʻesuʻega, faʻaaogaina suʻesuʻega feʻaveaʻi faʻatasi i le TH-positive SK-N-BE (2) C ma MN9D sela, matou te faʻaalia ai o le AR o loʻo faʻaalia le faʻaogaina o le TH promoter galuega i se faiga faʻalagolago. O su'esu'ega fa'asolo ma fa'atonu i luga o le saite ua fa'afanua ai se fa'ailoga androgen elemene tali (ARE) i totonu o se itulagi mai le -1562 i le -1328 taitoalua faavae i luga o le TH promoter. Na matou mauaina foi o le DJ-1, o se tasi na faʻaalia talu ai nei genes o ona suiga e mafua ai le ma'i o Parkinson, fa'atulafonoina le fa'agaioiina o le TH fa'alagolago i le AR e tusa ma le 50% i sela SK-N-BE(2)C. Faʻavae i luga o nei faʻamatalaga, matou te fautua atu e faʻagaoioia e AR le TH gene fa'amatalaga ma e mafai e le DJ-1 ona fa'aogaina le AR gaoioiga e pei o fa'aliliuga so'o fa'atasi.
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