puna
Mai le McLean Hospital Brain Imaging Center ma le Matagaluega o Psychiatry (DHH, KCY, IKL, PFR), Harvard Medical School, Belmont, MA; le Matagaluega o Psychiatry (YSL, EYK), Chung-Ang University Medical School, Seoul, Korea i Saute; ma le Matagaluega o Psychiatry (IKL), Seoul National University College of Medicine, Seoul, Korea i Saute.
lē faʻatino
Tele taaloga vitio i luga ole laiga (EIGP) ua tula'i mai ose mafua'aga autu o fa'afitauli tau amio ma le atina'e i tupulaga talavou. O suʻesuʻega talu ai nei na aʻafia ai le matafaioi a le striatal dopaminergic system i le faʻaogaina o amioga e fesoʻotaʻi ma le EIGP.
O lenei suʻesuʻega o loʻo suʻesuʻeina uiga faʻalagolago i taui i tupulaga talavou EIGP ona e ono fesoʻotaʻi ma genetic polymorphisms o le dopaminergic system ma uiga.
E fitu sefulu iva tama talavou EIGP ma 75 tausaga-ma le itupa-tutusa ma le soifua maloloina faʻatusatusa talavou na faʻafaigaluegaina. O faʻalapotopotoga na faʻataʻitaʻiina e tusa ai ma le fua faʻalagolago i taui (RD) i le Cloninger's Temperament and Character Inventory ma ala o le 3 dopamine polymorphisms: Taq1A1 allele o le dopamine D2 receptor (DRD2 Taq1A1) ma Val158Met i le Catecholamine-O-Methyltransferase (COMT). ) kenera. O le Taq1A1 ma le maualalo o gaioiga (COMT) alleles na sili atu ona taatele i le vaega EIGP e faʻatatau i le faʻatusatusaga vaega.
O le vaega o le EIGP o lo'o i ai nei e sili atu le maualuga o togi RD nai lo le fa'atonuga. I totonu o le vaega EIGP, o le i ai o le Taq1A1 allele e fesoʻotaʻi ma togi maualuga RD. O a matou suʻesuʻega o loʻo fautua mai ai o mataupu a le EIGP e maualuga atu le faʻalagolagoina o taui ma le faʻateleina o le DRD2 Taq1A1 ma le COMT alleles. Aemaise lava, o le DRD2 Taq1A1 allele e foliga mai e fesoʻotaʻi ma le faʻalagolago i taui i talavou EIGP.
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